Báo cáo y học: " HIV-1 Accessory Protein Vpr: Relevance in the pathogenesis of HIV and potential for therapeutic interventio" ppsx
Báo cáo y học: " HIV-1 Accessory Protein Vpr: Relevance in the pathogenesis of HIV and potential for therapeutic interventio" ppsx
... quantities of Vpr. 2). Vpr promotes the binding of the PIC (including MA, integrase (IN) and proviral DNA) to importins and nucleoporins, thereby facilitating nuclear entry of HIV- 1 provirus into the ... pre-viously, Vpr plays a significant role in the permissiveinfection of HIV- 1 into macrophages and may increase the survival of infected myeloid cells; therefore, it isindirectly related to HIV- D pathogenesis. Vpr ... impairment in HIV- 1 patients as well as anecessary factor for the infection and survival of HIV infected macrophages, thereby further contributing to the pathogenesis of HIV- D.Vpr and HIVAN HIV associated...
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Báo cáo y học: "What do biomarkers tell us about the pathogenesis of ankylosing spondylitis" ppsx
... activity, and pathogenesis in ankylosingspondylitis. Biomarkers reflecting disease activity (metallo-proteinase-3) and inflammatory lesions on magnetic resonanceimaging predict new bone formation ... syndesmophytes,complete resolution of inflammation at a vertebral cornerfollowing the institution of anti-TNF therapy does not prevent the development of new syndesmophytes [10]. On the contrary, ... receiving standard therapy hasnot revealed any significant difference [8,9]. Prospective MRIexamination even shows that while inflammatory changes in the spine predict the development of new syndesmophytes,complete...
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Báo cáo y học: " Chemokine blockade: a new era in the treatment of rheumatoid arthritis" ppsx
... of a variety of inflammatory chemokines and their receptors [5,6]. In vitrostudies have suggested that both so-called homeostaticchemokines and inflammatory chemokines, including CCchemokine ... toward the synovialcompartment in RA [7–10].Although these studies might suggest therapeutic potential for chemokine and chemokine receptor blockade in inhibiting chronic synovial inflammation, there ... & Therapy Vol 6 No 3 Haringman and TakRecently, there has been an enormous upsurge in investigations on the potential of chemokine blockade as anovel therapeutic strategy to inhibit inflammation...
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Báo cáo y học: "Cold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertension" ppt
... processesunderlying RP and PAH contribute to the familiar pattern of skin, renal and gastrointestinal pathology. The emergence of effective and conveniently administered therapy for PAHincreases the importance ... at1 year and 2 years of 96% and 89% compared withViewpointCold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertensionFrances C HallUniversity of ... cell dysfunction is characterised bydecreased production of the vasodilators nitric oxide and prostacyclin, and by enhanced release of endothelin-1.Endothelial cell dysfunction influences the...
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Báo cáo y học: "Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity" pdf
... correlationbetween MMP activity (evidenced by the 342FFGVG-G2 and CTX biochemical markers) and the inability of cytokine-treatedchondrocytes to initiate and/ or maintain anabolic activity.Switching to anabolic ... generated by an array of MMPs, of which MMP-2 and MMP-9 are only a subset. Onother occasions, the presence of these gelatinases has beena valid indication of total MMP activity and thereby the cata-bolic ... synthesis in cartilage explants was measured by the concentration of N-terminal pro-peptides of type II collagen in the condi-tioned medium using the PIINP enzyme-linked immunosorbent assay...
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Báo cáo y học: "AIT test has no problem in the detection of anti-ribosomal P" ppsx
... qualitycontrol program run by the Korean Society of LaboratoryMedicine [3]. In 1999 and 2007, reports of antinuclearantibody test using the IT-1 cell line on 208 and 588systemic lupus erythematosus ... commercialized and passed inspection by the Korea Food and Drug Administration in South Korea.Currently, IT-1 is being used under the name of the autoimmune target (AIT) test and it participates in the ... anti-ribosomal P (anti-Rib-P) in the pictures they revealed. In addition to the anti-Rib-P that Mahler and colleagues mentioned, limitations of the HEp-2 cell line in the detection of autoantibodies such...
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Báo cáo y học: " AIT test has no problem in the detection of anti-ribosomal P – authors’ response" docx
... systematic study is mandatory to compare the sensitivity and specificity of the AIT test for the detection of anti-Rib-Pantibodies and other antibody specificities using a variety of contemporary diagnostic ... assay, and then used these sera to determine the positivity and stainingpatterns in the AIT test. This method raises concernsbecause it is generally known that immunodiffusion is arelatively insensitive ... Despite the clearance of the AIT test by the South Korea Food and Drug Administration, to the best of our knowledge this test is not widely used as ascreening method – neither is it approved by the...
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Báo cáo y học: "Heel raises versus prefabricated orthoses in the treatment of posterior heel pain associated with calcaneal apophysitis (Sever’s Disease): study protocol for a randomised controlled trial" ppt
... randomisedtrial for the first time. The outcomes of this trial aretherefore likely t o strongly influence practice guidelines and clinical care in this area.This trial will be limited by its inability to ... faces painscale for the self-assessment of the severity of pain experienced bychildren: Development, initial validation, and preliminary investigation for ratio scale properties. Pain 1990, ... into the secondarygrowth plate of the calcaneus. The calcaneal growth cen-tre or apophysis appears at approximately seven years of age [4] and fuses in girls of age approximately thirteenyears...
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Báo cáo y học: "Acute liver toxicity with ifosfamide in the treatment of sarcoma: a case report" doc
... vascularinjury [6]. While certain drugs are known to cause spe-cific types of injury, the type of injury in idiosyncraticdrug reactions can be of variable morphology. A liverbiopsy can be performed ... of acrolein, for example, mayhave been of clinical value t o elucidate the mechanism of idiosyncratic hepatotoxicity. The main treatment of drug-induced liver toxicity iswithdrawal of the offending ... consent was obtained from the patient for publication of this case report and any accompany-ing images. A copy of the written consent is availabl e for review by the Editor -in- Chief of this journal.Author...
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Báo cáo y học: " Sustained favorable long-term outcome in the treatment of schizophrenia: a 3-year prospective observational study" ppsx
... judgment and insight, stereotyped thinking, and poor attention items of the scalePsychosis SCAP-HQ Bothered much by feeling that others are spying against you or plotting against you,hearing voices ... prior to initiation of the study, and the study was conducted in accordance with the ethicalprinciples that have their originintheDeclarationofHelsinki and are consistent with good clinical practices and ... between them and their family, and the protection they haveagainst being robbed or attackedSatisfaction with social life SCAP-HQ Combines the patient’s feeling about the way they spend their...
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