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Báo cáo y học: " Modulation of HIV-1-host interaction: role of the Vpu accessory protein" pps

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Báo cáo y học: " A cell surface interaction network of neural leucine-rich repeat receptor" doc

... prey. The bait proteins were biotinylated monomers, each containing a carboxy-terminal tag of the rat CD4 domains 3 and 4 and an enzymatically biotinylatable sequence. The prey also contained the ... this interaction frequency liesbetween large-scale binary yeast-two-hybrid assays (approxi-mately 0.01%) [37] and the LUMIER assay (approximately8%) [38]. The paucity of zebrafish protein interaction ... analysis of the Unc5b-Flrt interactions. Off-rate constants (koff) were calculated by globally fitting a first order decay curve to the dissociation phase of three concentrations of Unc5b;...
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Báo cáo y học: "Is there any cardioprotective role of Taurine during cold ischemic period following global myocardial ischemia" pps

... spectrophotometrically, bydirect measurement of the decrease of light a bsorptionat 240 nm caused by the decomposition of hydrogenperoxide by Catalase [15].Statistical AnalysisSPSS for Windows ... were main-tained in the Gülhane Military Medical Academy fullyaccredited Animal Care Facility under the rules and reg-ulations of the Care and use of Laboratory animals.Study DesignFollowing ... three days before the study. They were fed with stan-dard rat feed (Bil-Yem Food Industry, Yenikent-ANKARA/TURKEY) and tap water was placed near the cage. Four groups, including randomly chosen...
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Báo cáo y học: "Chronic arthritis leads to disturbances in the bone collagen network" pps

... synthesisobserved by multiphoton microscopy analysis showedthat there was a net loss of bone type I collagen in arthri-tis and that this is not due to diminished synthesis, as ver-ified by ... itsarchitectural quality (SHG signals assessed by multipho-ton microscopy).Collagen fiber orientation determines the topographyand extent of the deposition of hydroxyapatite bone min-eral in the extracellular ... furtherinfluences the elasticity of bone and is mainly responsiblefor its ability to absorb energy until the point of fracture,which can be assessed using the three-point bending test of arthritic...
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Báo cáo y học: "itfalls in haemodynamic monitoring based on the arterial pressure waveform" ppsx

... estimate of CO. However, despite its simplicity of use, the reliability of this system is uncertain during conditions of haemodynamic instability, when the dose of vasopressors changes rapidly but ... conventionally using a thermodilution pulmo-nary artery catheter. During these conditions of pharma-co logically driven changes in vascular tone, the bias and the limits of agreement of the FTV ... uncalibrated, are still strongly infl uenced by factors that aff ect ABP and APW independently of SV and CO.  e quality of the APW, the degree of the pressure wave refl ection at the arterial site (that...
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Báo cáo y học: " Modulation of the virus-receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody" ppsx

... out with V5 may contribute to the phenotype of the B28 Env. The sensitivity of the B19 V5chimera to antagonists of the virus-receptor interactiondid not differ significantly from the GL8 ABSN ... vitro. Why should FIV alter the way it interacts with CD134? Our studies with antago-nists of the CD134 interaction suggest that the affinity of the Env for the primary receptor CD134 may alter ... (not shown) suggesting that the tar-geting of V5 was not a vagary of the assay systememployed to measure VNA. The recognition of a linearpeptide from variant B28 by the post-mortem plasmafrom...
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Báo cáo y học: " Modulation of HIV-1-host interaction: role of the Vpu accessory protein" pps

... focus on the recent progress in our understanding of the functionsandmodeofactionoftheHIV-1Vpuaccessoryproteinand relate these to the pathogenesis of the virus as wellas the emergence of pandemic ... Access Modulation of HIV-1-host interaction: role of the Vpu accessory proteinMathieu Dubé1†, Mariana G Bego1†, Catherine Paquay1†, Éric A Cohen1,2*AbstractViral protein U (Vpu) is a type ... unclear whether Vpu subverts recy-cling and/or other intracellular sorting steps of Tetherin.Mutation of the overlapping Tyrosine (Tyr6 and Tyr8)trafficking signals in the Tetherin cytoplasmic...
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Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules pptx

Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules pptx

... obviously represent the next logicalstep in the unfolding story of the modulation of the oligomeric structures of HIV-1 viral enzymes by syntheticpeptides and small molecules.ACKNOWLEDGEMENTS The ... through modification of theiramino-acid composition and the addition of a hydrophobicmoiety, such aminocaproyl or palmitoyl, to the N-terminus of the peptide [20]. The development of these Ômore potentÕpeptide ... 2002 Modulation of the quaternary structure of HIV-1 enzymes (Eur. J. Biochem. 269) 5105REVIEW ARTICLE Modulation of the oligomeric structures of HIV-1 retroviral enzymesby synthetic peptides...
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Báo cáo Y học: Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition ppt

Báo cáo Y học: Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition ppt

... hans-ulrich.demuth@probiodrug.deAbbreviations: Fmoc-Ala-Pyrr-CN, 9H-fluorenyl-9-ylmethylN-[2-(2-cyano-1-pyrrolidinyl)-1-methyl-2-oxoethyl]carbamate;NHMec, 7-(4-methyl)coumarylamide; PEP, prolyl endopeptidase.Enzyme: prolyl endopeptidase ... are distinct from trypsin-type andsubtilisin-type serine peptidases in their structure and the order of the catalytic triad residues in the primary sequence[2,3]. The recently reported three-dimensional ... domain. The propeller domain probably con-trols the access of potential substrates to the active site of the enzyme and excludes peptides containing more than 30amino acids.Although the enzymatic...
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Báo cáo y học: "Modulation of granulocyte-endothelium interactions by antileukoproteinase: inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium" ppt

... Inhibition of leukocyte rolling along the postcapillary endothelium by antileukoproteinase in vivo. The results show the frac-tion of leukocytes rolling along the endothelium of postcapillary synovial ... (b) Inhibition of leukocyte adherence to the postcapillary endothelium by ALP in vivo. The results show the number of leukocytes adherent to the endothelium of postcapillary syn-ovial venules ... Germany). The phase contain-Figure 1Inhibition of leukocyte interaction with the postcapillary endothelium by ALP in vivoInhibition of leukocyte interaction with the postcapillary endothelium by...
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Báo cáo y học: "Modulation of LPS stimulated NF-kappaB mediated Nitric" pptx

... pictorial summary of these findings.However, these conclusions have been drawn on the basis of use of well characterised inhibitors, rather then actualmeasurement of the activity of the target proteins ... kinase(RACK) and thereby prevent nuclear-cytoplasmic translo-cation of specific PKC isoforms [29]. The addition of aTAT sequence (GGGGYGRKKRRQRRR-GGGG) to the MALY peptides ensures that they are transported ... [28]. The induction of NOS2 activity upon activation of PKC by LPS stimulationhas also been demonstrated previously using a non-selec-tive inhibitor of all PKC isoforms [16]. However, the role of...
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