... activator of macrophages and a potent inhibitor of osteoclastogenesis invitro, it is also known that this cytokine is produced in particularsettings of inflammatory bone loss, such as infection and psoriatic ... influ-enced by cytokines. The proinflammatory cytokines tumornecrosis factor alpha, IL-1, and IL-6 augment osteoclasto-genesis [9–11], while IL-10, IL-12, IL-18, and IFN-γ anta-gonize osteoclastogenesis ... early RANKL signal. The strength of the early RANKL signal may be altered in the setting of inflammatory bone diseases such asrheumatoid arthritis, in which high levels of RANKLexpressed on either...