... alpha helices and the C-terminal region in nuclear localization and G2arrestremain controversial. Through extensive mutational ana-lysis, Mahalingam and others put forth a hypothesis that the ... SciUSA 1999, 96:12039-12043.239. Shimura M, Tanaka Y, Nakamura S, Minemoto Y, Yamashita K, Hatake K,Takaku F, Ishizaka Y: Micronuclei formation and aneuploidy induced byVpr, an accessory gene of ... individual peptides to localize to the nucleus. Later, Kamata and others found that Vpr aH1 and aH3 both bind importin -a, thattheIBBdomainofimportin -a primarily d etermines this interaction, and that...