... rekindled interest in the use of
thyroid hormone therapy in critical illness. Continued improvements
in survival after critical cardiac illness provokes the question of
whether thyroid hormone therapy ... of thyroid hormone therapy in acutely ill cardiac patients
Kathleen L Wyne
Assistant Professor, Division of Endocrinology and Metabolism, Department...
... clear
whether or not H39 is dominantly tuning the V
H
⁄ V
L
interaction of other Fvs, including HyHEL-10. In
addition, the effect of the H39 mutation on antigen
binding has not yet been analyzed. ... improved the antigen-binding affinity of Fv,
similarly to the level of scFv (Table 2).
Some single V
H
domains of anti-protein IgG, inclu-
ding HyHEL-10 and D1.3, were known to retain...
... Cardie, Vincent Ng, David Pierce,Chris Buckley. Ex-
amining the role of statistical and linguistic knowledge
sources in a general-knowledge que stion answering sys-
tem. In Proceedings of the 6th ... resolution. In the following example, a
chain of coreference links Bill Gates and Mi-
crosoft founder in the candidate answer:
Answer Question
Q318: Where did Bill Gates go to col...
... glu-
cokinase and hexokinase I in distinct pools [3,24], or
by the involvement of mechanisms, additional to
Glc6P, in mediating the effects of glucokinase over-
expression. As glucokinase binds ... the increase of Glc6P in the presence of
S4048 was caused by the inhibition of Glc6P hydro-
lysis in the absence of detectable changes in glucose
phosphorylation.
S4048 causes...
... tight
binding affinity was demonstrated towards lauric acid,
resulting in the synthesis of mainly x-1 hydroxylated
lauric acid, suggesting a role in the lipid oxidative
metabolism. Interestingly, ... mem-
ber of subfamily A of family 94 (there is more about
the activity of this enzyme in the accompanying mini-
review by Pinot & Beisson [4]). Over 11 000 P450
genes are inclu...
... Nuijens
Pharming, Archimedesweg, Leiden, the Netherlands
Lactoferrin (LF) is an iron-binding glycoprotein of the
innate host defence system. To elucidate the role of N-linked
glycosylation in protection of ... Properties of the iron-binding site of the N-terminal lobe of
human and bovine lactotransferrins. Importance of the glycan
moiety and of the non–covalent interaction...
... study in which overexpression
of ADAM10 in HEK293 cells increased the a-secretase
cleavage of APP, while expression of a dominant negative
form of ADAM10 with a point mutation in the zinc
binding ... ADAM10 and TACE are not critically
involved in the shedding of ACE.
APMA has been reported to induce the shedding of a
number of protein ectodomains, including APP, from
CHO...
...
to
fulfill
the
chilling
requirement
to
break
winter
dormancy
in
Scots
pine
has
been
stressed
(e.g.,
Wareing,
1951;
Vegis,
1965;
Sarvas,
1974).
In
the
following,
I will
use ...
however.
Ins-
tead
the
plants
formed
more
stem
units.
The
role
of
photoperiod
and
temperature
in
the
induction
and
the
release
of
dormancy
in
Pinus
sylvestris
L.
s...
... the role of adjuvant pelvic RT in rec-
tal cancer with synchronous liver metastasis has not
been defined. In this study, we investigated the clinical
implications of adjuvant pelvic RT following ... Stone MD: The role of surgical resection of liver metastases in
colorectal carcinoma. Seminars in oncology 1991, 18:399-406.
3. August DA, Ottow RT, Sugarbaker PH: Clinical per...
...
Amplification of MYCN was confirmed to be a strong
predictor of adverse outcome, but other single genomic
alterations, such as loss of 11q or gain of 17q, were
overridden by the presence of any kind of ...
limited by the instability of mRNA in comparison with
DNA, which will require strict adherence to elaborated
standard operating procedures in the processing of
tum...