Báo cáo khoa học: "Short-term effects of positive end-expiratory pressure on breathing pattern: an interventional study in adult intensive care patients" pot

... effects of positive end-expiratory pressure on breathing pattern: an interventional study in adult intensive care patientsChristoph Haberthür1 and Josef Guttmann21Assistant Professor and ... compliance alterations in PEEPshould result in stronger changes in lung volume, and sostronger PEEP-related effects on breathing pattern are antici-pated in this setting. The findings of our and ... patternduring the investigation did not suggest expiratory flow limita-tion as an indirect sign of the occurrence of intrinsic PEEP.Conclusion In tracheally intubated, spontaneously breathing adult patients,...

Báo cáo khoa học: The effects of a-secretase ADAM10 on the proteolysis of neuregulin-1 pot

... O-gly-cosylation of NRG-1 [54], the deviation in the size of the soluble protein fragment may depend on differentglycosylation patterns in the investigated cell lines. In mouse brain membranes, a panel of ... ⁄ ) embryonic mouse ﬁbro-blasts [55] suggested only a minor in uence of ADAM10 on neuregulin-1 shedding, but any positive proof in the living animal was still missing. Therefore,we investigated ... solublefraction of mouse brain contained a secreted form of NRG-1 of 55–60 kDa.Fig. 1. Isoforms of NRG-1 expressed in the human astroglioma cell line U373 and mouse brain. (A) In general, three...

Báo cáo khoa học: Multiple effects of DiS-C3(5) on mitochondrial structure and function pot

... two additional novel effects of DiS-C3(5) on mitochondria: (i) inhibition of the Ca2+-induced PT by a low concentration of DiS-C3(5) and (ii)induction of swelling in the absence of Pi.Withrespecttothe ... presence of Pi in the incubationmedium [6–8]. Furthermore, the accelerating effects of thesecyanine dyes on the mitochondrial oxygen consumptionwere attributable mainly to the induction of the ... poly(ethyleneglycol) and analysis of mitochondrial configuration bytransmission electron microscopy revealed that the a cceler-ating effect of DiS-C3(5) on mitochondrial oxygen con-sumption reflects t he induction...

Báo cáo khoa học: Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-b1 induced murine tissue inhibitor of metalloproteinases-1 gene expression docx

... Mulholland NM, Soeth E & Smith CL (2003) Inhibi-tion of MMTV transcription by HDAC inhibitorsoccurs independent of changes in chromatin remodel-ing and increased histone acetylation. Oncogene ... com-plex; anti-Sp3 Ig blocks formation of bands b and c.This suggests that band a contains Sp1, band b con-tains both Sp1 and Sp3, and band c contains Sp3.DiscussionHDACs usually act as transcriptional ... expression of Timp-1, only on induced gene expression. In conclusion, this is to our knowledge, the onlydescribed instance of HDAC inhibitors having oppos-ite effects on the same gene, depending upon...

Báo cáo khoa học: Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons ppt

... Ca2+ in ux.Effect of EPCG, catechin hydrate, curcumin, apige-nin, naringenin and gallotannin on QUIN-inducedintracellular Ca2+ in cultured human neuronsAs mentioned above, QUIN stimulation induced ... apigenin and naringenin.Effect of EPCG, catechin hydrate, curcumin,apigenin, naringenin and gallotannin on QUIN-mediated NAD+depletion, extracellularLDH and PARP activation in human neuronsTo ... production in human neuronsWe investigated the effect of QUIN on nNOS activity in cultured human neurons. Primary human neuronswere treated with QUIN for 30 min at increasingconcentrations. A...

Báo cáo khoa học: "Interactive effects of waterlogging and irradiance on the photosynthetic performance of seedlings from three oak species displaying different sensitivities (Quercus robur, Q petraea and Q rubra)" docx

... Cheeseman JM ( 1992) Effects of root hypoxiaand a low P supply on relative growth, carbon diox-ide exchange rates and carbon partitioning in Pinusserotina seedlings. Physiol ... petraea.The fraction of seedlings affected by theseOriginal articleInteractive effects of waterlogging and irradiance on the photosynthetic performance of seedlingsfrom three ... the end of the stress,or after 3 weeks of drainage. Despite its late application, after completion of elongation and expan-sion of leaves, shading significantly reduced...

báo cáo khoa học: "Enhancive effects of Lewis y antigen on CD44-mediated adhesion and spreading of human ovarian cancer cell line RMG-I" pps

... S: CD44 stimulation induces integrin-mediated adhesion of colon cancer cell lines to endothelial cells by up-regulation of integrinsand c-Met and activation of integrins. J Cancer Res 1999, 59:4427-4434.36. ... adhesion and s preading of ovarian cancercells. Inhibiting the expression of CD44 or blocking itsbinding to receptors and downstream signal moleculescan inhibit the progression of ovarian cancer.Glycoconjugates, ... AccessEnhancive effects of Lewis y antigen on CD44-mediated adhesion and spreading of human ovarian cancer cell line RMG-ILili Gao1, Limei Yan1, Bei Lin1*, Jian Gao1, Xiuyun Liang1, Yanyan...

Báo cáo khoa học: "The effects of different weaning modes on the endocrine stress respons" potx

... The aim of the present study was to compare changes in plasma concentrations of insulin, cortisol and glucose, and in urine vanilmandelic acid (VMA) during weaning and afterextubation, using the ... response on plasma insulin, cortisol, glucose, and urinary vanilmandelic acid during weaning and after extubation,using pressure support (PS), continuous positive airway pressure (CPAP) and ... prolongation of mechanical ven-tilation increases the risk of complications, including bron-chopulmonary infections, barotrauma, and oxygen toxicity, itspremature discontinuation may also increase...

Báo cáo khoa học: "A Effects of coagulation factor XIII on intestinal functional capillary density, leukocyte adherence and mesenteric plasma extravasation in experimental endotoxemia" docx

... injec-tion of anti-endothelial cell antiserum administered into thedorsal skin. Antiserum or a mixture of antiserum and F XIII wasinjected after Evans blue injection, and later the quantity of Evans ... expressed on the surface of monocytic cells and some evidence indicates the involvement of transglutaminases in cell adhesion, for example, they caninfluence adhesion of monocytic cells on fibronectin ... the Institutional Review Board for the care of animal subjects (protocol G 0133/00) and performed in accordance with German legislation on the protection of animals.Anesthesia and monitoringThe...

Báo cáo khoa học: "The effects of continuous venovenous hemofiltration on coagulation activation" pot

... finding confirms the results of Salmon and colleagues, who did not find an increase in con-tact activation during CVVH using a polyacrilonitrile mem-brane and systemic heparinization [6]. Interestingly, ... TFPI increases after administration of heparin [18],and because high TFPI levels may bind FVIIa. In our study CVVH was performed without administration of heparin, andno changes in markers of ... coagu-lation were observed.What is the mechanism of increased thrombin generation in the absence of detectable activation of the extrinsic coagula-tion system and intrinsic coagulation system? One...

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