... (NationalInstitute of Advanced Industrial Science and Technol-ogy, Tokyo, Japan), Yaoqi Zhou (University of Buf-falo), Ming Li (University of Waterloo, Canada). Theresults and a description of the methods ... that, thanks to the insightsand efforts of these groups, as well as to the hard work of many others, the problem of predicting the overalltopology of many proteins is clearly within reach, ... to those of the best research groups.The appearance of the above mentioned fragment-based methods for predicting the structure of proteinswith a new fold had the undesirable effect of discour-aging...