Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx
Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf
... to increasing intracellular stores of GSSG, a potent inhibitor of NF-κB transcription factor DNA binding. The pathway leading to the formation of GSH by the action of γ-glutamylcysteine synthetase ... effectson hyperoxia-induced lung injury and mortality. Treatment withlisofylline inhibited hyperoxia-associated increases in TNF -α, IL-1β and IL-6 in the lungs as well as decreasing the levels of hyperoxia-induced ... lungs before any increase in proinflammatorycytokine protein occurs, and they further suggest that NF-κBactivation may represent an initial event in the proinflammatorysequence induced by hyperoxia....
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx
... and inflammatory stimuli, and hypoxemia and the crucial role of hypoxia-inducible factor in mediating lung injury. Changes in the pattern of gene expression through regulatory transcription factors ... overview of the potential signaling pathways involved in cytokine-mediated regulation of hypoxia-induced hypoxia-inducible factor- 1α (HIF- 1α) translocation and activation. Hypoxia and inflammatory signals ... therefore involves complex inter-actions of multiple cellular pathways [1,2].ReviewScience review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury:...
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Báo cáo y học: "Fat-Storing Multilocular Cells Expressing CCR5 Increase in the Thymus with Advancing Age: Potential Role for CCR5 Ligands on the Differentiation and Migration of Preadipocytes" pot
... adipocytic/fat-storing mesenchymal cells and loss of thymocytes with advancing age lead to a novel con-ceptual point of view concerning the understanding of the process of thymic physiology in ... observed in thymocytes and in mul-tilocular cells in the septa and inside the thymic pa-renchyma. These data reinforced the hypothesis that adipocytic mesenchymal cells could be possibly im-migrating ... by the age-associated increases in the staining of thymocytes and microenvironmental cells, including the multilocular fat-storing cells. These data suggest that chemokines may influence the...
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Báo cáo y học: "Science Review: Vasopressin and the cardiovascular system part 1 – receptor physiology" doc
... V3pituitary and oxytocin receptors, and the P2class of purinoreceptors. Knowledge of the function and distribution of vasopressin receptors is key to understanding the seemingly contradictory actions ... G-proteins of the Gq/11 family. The α- subunits regulate the activ-ity of the β-isoforms of phospholipase C [29]. A variety of signaling pathways is associated with the V1R, and thesepathways include ... excretionfrom the kidney by increasing the osmotic water permeability of the renal collecting duct – an effect that is explained bycoupling of the V2R with the Gssignaling pathway, whichactivates...
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Báo cáo y học: "Science Review: Vasopressin and the cardiovascular system part 2 – clinical physiology" pps
... vasopressininteraction in these pathways. We discuss the seemingly con-tradictory studies and some new information regarding the actions of vasopressin on the heart. Finally, we summarize the clinical ... vasodilation of others.Vasopressin and the heart The actions of vasopressin on the heart are complex and the studies are seemingly contradictory. Depending on the species studied, the dose used, and the ... independently of coronary blood flow, the effects of vasopressin on inotropy were strikingly different. By main-taining constant coronary flow, the direct cardiac effects of vasopressin on an isolated...
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Báo cáo y học: "Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis" potx
... Sweden) and the bands were revealed bysilver staining. The gels were scanned and the intensity of each band on the gel was analyzed with IPLab Gel soft-ware (BioSystematica, Plymouth, UK). The ... for assigning the patients to various categories, we set the intensity of the 676-bp band of the molecular mass marker on eachgel as the arbitrary cutoff point (Fig. 1, arrow). The intensityFigure ... the type of inflammation seen in mtDNA-injectedmouse joints. It is also worth emphasizing that the process of inflammation in RA joints is dynamic, with the infiltration of new inflammatory cells,...
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Báo cáo y học: " Overlapping enhancer/promoter and transcriptional termination signals in the lentiviral long terminal repeat" doc
... biology studies.LJC conceived the study. LJC, SS and AL initiated the design of the study and QY performed the statistical anal-ysis. LJC and QY participated in the final figure prepara-tion and ... nt of U3C.Analysis of key termination signals contributing to LV RNA readthroughU3C contains NFκB and Sp1 binding sites and TATA box.To dissect the role of these transcription factor bindingsites, ... SINvector could compromise the intended safety feature. Thismay be overcome by further characterization of the RNA transcription elongation and termination machinery and genetically modify the...
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Báo cáo y học: "Clinical review: Intra-abdominal hypertension: does it influence the physiology of prone ventilation" doc
... secondarily in uences IAP/IAH is likely to greatly in uence respiratory mechanics and outcomes. Further study of the role of IAP/IAH in the physiology and outcomes of PV in hypoxemic respiratory failure ... IAH and intra-abdominal volume or thus the compliance of the abdominal wall, and of the potential di erence in the abdominal in uences between the extrapulmonary and pulmonary forms of acute ... pulmonary and extrapulmonary – refl ecting either direct lung injury or indirect injuries to the pul monary endothelium as mediated by the systemic in am matory response [20,21]. In particular, the...
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Báo cáo y học: "Pro/con clinical debate: Are steroids useful in the management of patients with septic shock" ppt
... of catecholamine dysfunction and refractory hypotension [5].Downregulation of catecholamine receptors occurs withprolonged use of exogenous catecholamines and this may bereversed with administration ... 60-year-old man has been in your intensive care unit withseptic shock for 5 days and he has required a norepinephrineinfusion for the entire time. He had multisystem organ failurebut most of ... Simone†‡, Randy Wax§¶, Katherine G Craig** and Keith R Walley††*Resident, Department of Medicine, University of Toronto, Canada†Resident, Division of Thoracic Surgery, University of Toronto,...
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Báo cáo y học: "Pro/con clinical debate: Antibiotics are important in the management of patients with pancreatitis with evidence of pancreatic necrosis" ppt
... Cohn41Professor and Chief of Intensive Care and Accident Department, University Hospital Maastricht, The Netherlands2Trauma Surgeon and Intensivist, University Hospital Maastricht, The Netherlands3Fellow ... sepsis and mortality. They included a study by Luiten and colleagues[8], which used selective decontamination of the digestivetract. Selective decontamination is attractive as it may allow the ... decont-amination of the gastrointestinal tract for the purpose of pos-sibly decreasing bacterial inoculation of the necroticpancreatic tissue via translocation [8]. One hundred and twopatients...
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngchuyên đề điện xoay chiều theo dạngNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Nghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Thơ nôm tứ tuyệt trào phúng hồ xuân hươngChuong 2 nhận dạng rui roTranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)