... families of cysteine pro-tease inhibitors. Clitocypin inhibits papain, cathepsins L and K, legumain and bromelain, but is inactive againstcathepsin H, trypsin and pepsin. Clitocypin is encodedby ... in most macrocypins, and of several histidine and methionine residues in all the macrocypin sequences,all of which are absent in clitocypin. High proline and glycine contents were, ... )55, indicatingFig. 1. SDS–PAGE analysis of the natural cysteine protease inhibi-tors clitocypin (nClt) and macrocypin (nMcp). Clitocypin (from Clito-cybe nebularis) and macrocypin (from Macrolepiota...