... (dehydro-genation, hydroxylation, and N-dealkylation), mainly bycytochrome P450 2D6 (CYP2D6) and cytochrome P4503A4 (CYP3A4) [60]. The parenteral drug is excreted only in traces. There is only ... (7-(4-[4-(2,3-dichlorophenyl)-1-piperazi-nyl]butyloxy)-3,4-dihydro-2 (1H)-quinolinone (OPC-14597), is a derivative of the dopamine autoreceptor ago-nist 7-(3-[4-(2,3-dimethylphenyl)piperazinyl]propoxy)-2(1H)-quinolinone ... dopamineautoreceptor agonists (in spite of being efficacious in the treatment of psychosis) might potentially increase the riskfor exacerbation of psychosis through stimulation of post-synaptic...