Báo cáo y học: " Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells" doc

... interleukin-8and granulocyte–macrophage colony-stimulating factor delay neutrophilapoptosis by stimulating these pathways, and implicate the activation ofPKB/AKT and the phosphorylation of BAD as ... resulting in the activation of multiple intracellular signalling cascades. Theseevents regulate a broad array of cellular responses including survival, activation,differentiation and proliferation ... lungs in manyrespiratory disease states and have a critical role in thepathogenesis of the acute respiratory distress syndrome(ARDS), pulmonary fibrosis, bronchiectasis and fatalasthma. Neutrophils...

Báo cáo y học: "Association of a single nucleotide polymorphism in growth differentiate factor 5 with congenital dysplasia of the hip: a case-control study" ppt

... Nishida K, Furuichi T, Toki H, Nishimura G, KawabataH, Yokoyama H, Yoshida A, Tominaga S, Nagano J, Shimizu A, Wakana S, Gondo Y, Noda T, Shiroishi T, Ikegawa S: A noveldominant-negative mutation ... Everman DB, Bartels CF, Yang Y, Yanamandra N, Goodman FR,Mendoza-Londono JR, Savarirayan R, White SM, Graham JM Jr,Gale RP, Svarch E, Newman WG, Kleckers AR, Francomano CA,Govindaiah V, Singh ... unrelated families. Am J Med Genet A 2003, 11 7A: 136-142.20. Miyamoto Y, Mabuchi A, Shi D, Kubo T, Takatori Y, Saito S, FujiokaM, Sudo A, Uchida A, Yamamoto S, Ozaki K, Takigawa M, TanakaT, Nakamura...

Báo cáo y học: " Is there a feudal hierarchy amongst regulatory immune cells? More than just Tregs" docx

... chronic inflammation in one or multiple organs[1]. During synovial inflammation, critical events include neo-angiogenesis, cellular hyperplasia, and a massive influx ofinflammatory cells such as ... 1The balance between pro- and anti-inflammatory cell types and cytokines dictates arthritic disease development. (a) During inflammation the joint isoverwhelmed by an influx of pro-inflammatory ... results in the joint architecture being destroyed and the synovia becoming inflamed. (b) Regulatory cell types that secrete anti-inflammatory cytokines, including IL-10 and transforming growth factor...

Báo cáo y học: "Period-2: a tumor suppressor gene in breast cancer" pdf

... Boulares AH, Yakovlev AG, Ivanova V, Stoica BA, Wang G, Iyer S,Smulson M: Role of poly(ADP-ribose) polymerase (PARP)cleavage in apoptosis. Caspase 3-resistant PARP mutantincreases rates of apoptosis ... machinery comprises a battery of transcriptionalactivators and repressors that form an auto-regulatorytranscriptional feedback loop. Clock and BMAL1 arepaired transcriptional activators that ... signaling pathway. The mechanism by whichPER 2 regulates Cyclin D1 and p53 expression is underinvestigation in our laboratory.Anchorage-independent growth in soft agar as a character-istic of in...

Báo cáo y học: "Treatment of a femoral shaft fracture in a patient with congenital hip disease: a case report" docx

... of symptoms.DiscussionFemoral shaft fracture is usually caused by a high energytrauma. In this case it is possible that trauma energywas rotational and totally absorbed by the femoral shaftdue ... close-locked intramedullary nailing [5]. In this case there was concern about the technical difficul-ties of antegrade nailing due to the distorted anatomyand the limited ability of intraoperative traction ... hip arthritis.She had fallen in her house while walking. On clinicalexamination, the leg was in fixed flexion with adductionand internal rotation. X-rays revealed an isolated spiralmid-shaft...

Báo cáo y học: "Treatment of a femoral shaft fracture in a patient with congenital hip disease: a case repor" ppt

... is usually caused by a high energytrauma. In this case it is possible that trauma energywas rotational and totally absorbed by the femoral shaftdue to the lack of motion at the dysplastic ... presentation: A 57-year-old Greek woman was admitted to the emergency department having sustained a spiral mid-shaft femoral fracture. She also suffered from an ipsilateral hip congenital dysplasia with ankylosed ... common in the adult Greek population. Its inci-dence has been dramatically reduced as a result of earlyscreening, immediate diagnosis and treatment afterbirth. Adults with congenital dysplasia...

Báo cáo y học: "Case reports: A helping hand to generalists Geoff Wong" doc

... Kilkenny L, Kinmouth A- L: Medically unexplained phys-ical symptoms in primary care: A comparison of self-reportscreening questionnaires and clinical opinion. Journal of Psycho-somatic Research ... see a 'rare' or novel condition may well be a generalist(something which is most likely in health care systemsthat have a strong and established primary care system).Secondly, we all ... regular email alerts? Youcan do so for JMCR online at http://jmedicalcasereports.com/alerts/ and for Cases Journal at http://casesjournal.com/alerts/. You can search JMCR's growing archive...

Báo cáo y học: " Nitric oxide: a pro-inflammatory mediator in lung disease?" potx

... to airway hyperresponsiveness and inflammation in a murine model of asthma. J Exp Med 1999, 189:1621–1629.11. Grasemann H, Yandava CN, Storm van's Gravesande K, Deykin A, Pillari A, Ma J, ... Kamisaki Y, Wada K, Bian K, Balabanli B, Davis K, Martin E, Behbod F,Lee YC, Murad F: An activity in rat tissues that modifies nitrotyrosine-containing proteins. Proc Natl Acad Sci USA 1998, ... induced by bacterial productsand pro-inflammatory cytokines. As such, inflammatorydiseases of the respiratory tract, such as asthma, acuterespiratory distress syndrome (ARDS) and bronchiecta-sis,...

Báo cáo y học: "Retrovirology highlights a quarter century of HTLV-I research" docx

... Molecular Microbiology, NIAID, NIH Bethesda, Maryland 20892, USAEmail: Kuan-Teh Jeang* - kj7e@nih.gov* Corresponding author Abstract In 1977, Takatsuki and co-workers described in Japan a human ... type I (HTLV-I), in a patient with cutaneousT-cell lymphoma. This month, Retrovirology commemorates these two land mark findings bypublishing separate personal recollections by Takatsuki and ... and Gallo respectively on the discovery ofATL and HTLV.Retrovirology as a medical study first emerged in the early1900s. In 1908, Ellermann and Bang reported on thetransmissibility of avian...

Báo cáo y học: "Availability of a pediatric trauma center in a disaster surge decreases triage time of the pediatric surge population: a population kinetics model" ppsx

... construction area as well as the availability of rapid transportation to and capacities of already existing nearby centers would have to be performed. Alternatively, a different approach would ... the availability of a pediatric trauma center upon the rates of admission and discharge of a disaster surge population by extrapolating from historical data. We find that the initial rate of ... t1 and t99 was motivated in large part by the availability of such data in the literature, but also by the importance of t1 as a defining timescale of the behavior of populations in the...

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