... reversedby oral and intravenous administration ofL-arginine. ThustheL-arginine transport through the membrane exerts aregulatory role in the pathwayL-arginine/NO. In most mammalian cells arginine ... amino acids lysine, arginine andornithine at the basolateral membrane of the polar epithelialcells in the intestine and renal tubules. LPI is caused bymutations in the SLC7A7 gene encoding ... dysfunction resulting fromL-arginine deficiency in a patient with lysinuric protein intolerance. J. Clin. Invest. 108,717–724.43. Kayanoki, Y., Kawata, S., Yamasaki, E., Kiso, S., Inoue, S.,Tamura,...