Báo cáo y học: " The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells" potx
Báo cáo y học: " The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells" potx
... purposes)Respiratory ResearchOpen AccessResearch The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cellsHuayan Zhang1, ... Muramatsu T: Midkine, a retinoic acid- inducible heparin-binding cytokine in inflammatory responses: chemotactic activity to neu-trophils and association with inflammatory synovitis. J Bio-chem ... caused by DEX-treatment in our study. This suggests that the RA-induced enhancement in septation and the rescue of GC-induced inhibition of alveolarization may not be medi-ated by affecting endothelial...
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Báo cáo y học: "Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthriti" docx
... contains six amino acids followed by a 20amino acid transmembrane domain at the amino terminus, aregion with several potential N-glycosylation sites, a cysteinerich substrate-binding domain and ... peroxidase activity was blocked by incubating tissue sections in 0.3%v/v H2O2 for 15 minutesthen washed for 3 × 3 minutes in PBS. Non-specific bindingwas blocked by incubating sections in 1.5% (v/v) ... expression is up-reg-ulated by pro-inflammatory cytokines IL-1 and OSM in chondrocytes and is induced during cartilage collagen resorp-tion. Furthermore FAPα gene expression is significantly ele-vated...
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Báo cáo Y học: The porcine trophoblastic interferon-c, secreted by a polarized epithelium, has specific structural and biochemical properties potx
... on the IFN-c polypeptide core. Theycould differ in the rate and site of glycosylation, considering the 22 500-Da band as bi-glycosylated and the 18 000-Daband as monoglycosylated (Fig. 2). The ... chains and four glycotypes. TrIFN-c collected in the uterus lumenwas enzymatically deglycosylated and analysed by massspectrometry (MALDI-TOF). The data revealed that the more abundant polypeptide ... modifications, includingglycosylation, are strongly dependant upon the type and physiological status of producing cells, and may signifi-cantly in uence the characteristics of a glycoprotein[16,17,29]....
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Báo cáo Y học: The DNA-polymerase inhibiting activity of poly(b-L-malic acid) in nuclear extract during the cell cycle of Physarum polycephalum pot
... thatpoly(b-L-malate) is active in maintaining mitotic synchronyof plasmodia b y playing the mediator between the periodicsynthesis of certain proteins and the catalytic competence ofDNA po lymerases.Keywords: ... remainsconstant during the cell cycle, and PMLA synthesized in excess amounts is secreted into the culture medium. In contrast to varying degrees of PMLA synthesis, the content in the nuclei is ... of the inhibitory activity in the cell cycle. The activity of DNA polymerases in the nuclear extractsafter neutralization of the inhibitory activity by spermidine hydrochlorideAlthough the...
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Báo cáo y học: "The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies" pptx
... interactions with the active site containing Y7 2, Y1 24, Y2 03 and Y3 37 aminoacids. In the PAS, the benzyl ring forms another π-πinteraction with the indole ring of W286. Despite the lack of π-π interaction ... present in the training set molecules. HypoGen [35], an algorithmthat uses the activity v alues of the small compounds in the training set to generate the hypothe sis, was applied in this study to ... activ-ities. The residual c ost (Table 1) is the differencebetween the cost of null hypothesis and the total cost. The larger the difference between the cost of the nullhypothesis and total cost, the...
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Báo cáo y học: " The natural history of West Nile virus infection presenting with West Nile virus meningoencephalitis in a man with a prolonged illness: a case report" doc
... natu-rally acquired meningitis and encephalitis in the NewYork City area [3].WNV infection typically peaksinlateJulythroughearly September [4]. The disease usually presents withthree clinical syndromes: ... resonance imaging(MRI) scans were obtained which correlated with the clinical course of the disease, hence supporting the use ofbrain MRI in rendering a preliminary diagnosis and following the progression ... (bilateral edema and hyperintensity of the basal ganglia and thalami) were helpful in this clinicalsetting to establish a preliminary diagnosis of WNND.Further, since clinical improvement correlated...
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Báo cáo y học: "The laminin b1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in an animal model of allergic asthma" potx
... asthmatics increasedexpression of laminin a2andb2chainsisobserved[18,19], and laminin g2 chain expression inversely corre-lates with epithelial integrity [19]. Laminins have notonly been shown to inhibit ... ASM remodelling in vivo, by treating the animals with the specific soluble laminin-competing pep-tide Tyr-Ile-Gly-Ser-Arg (YIGSR), a binding motif pre-sent in the b1 chain of laminins [26].MethodsAnimalsAll ... DNA-synthesis (by 56 ±11%, P < 0.05, Figure 5C) and cell number (not shown).This inhibitory effect was fully reversed by solubleYIGSR. Surprisingly , the inhibitory effect of coatedYIGSR...
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Báo cáo y học: "The use of cephalad cannulae to monitor jugular venous oxygen content during extracorporeal membrane oxygenation" pot
... oxygendelivery to the brain during ECMO, i ncluding systemicpH, type of ECMO and age of the patient. Future stu-dies should attempt to define optimal oxygen delivery to the brain. This study provides ... oxygenation and hemodynamics during induction ofextracorporeal membrane oxygenation as investigated by near infraredspectrophotometry. Pediatrics 1995, 95:555-561.24. Cain SM: Increased oxygen ... between 10 and 14 F. In pediatric patients, the same size or one sizesmaller than the venous drainage catheter is used. The catheter is then advanced in a retrograde fashion into the jugular vein until...
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Báo cáo y học: " The PIRO concept: P is for predisposition" ppsx
... thismorning show that comorbidity greatly increases the weightof infection in terms of prognosis. I guess the otherpredisposing or prognostic factor is how the patient wasbefore — this is ... studiesusing single nucleotide polymorphisms or insertion–deletionvariants are increasingly in the scientific literature. AMEDLINE search I performed for the terms “gene AND polymorphism AND atherosclerosis ... not only for clinical routine, but forexperimental hypothesis testing. We were interested in infectious diseases in relation to atherosclerosis, and wehave reported that a mutation of the toll-like...
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Báo cáo y học: "The PIRO concept: I is for infection" pot
... mortality in community-acquired infections — there you are talking aboutthis is the reason for admission, and yes they may haveunderlying diseases but they are dying of infection. Whenyou talk ... antibiotic therapy. So I think if the purpose of this is to try and speak a language thateverybody understands, to classify patients so that you cangroup them together in clinically relevant ways, then ... Gram-negative, and interestingly it is now becoming increasingly clear thatthere are different pathogenetic pathways. So even the basicstuff — whether this is a round blue thing or a long pink thing— may indeed...
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