... asthmatics increasedexpression of laminin a2andb2chainsisobserved[18,19], and laminin g2 chain expression inversely corre-lates with epithelial integrity [19]. Laminins have notonly been shown to inhibit ... ASM remodelling in vivo, by treating the animals with the specific soluble laminin-competing pep-tide Tyr-Ile-Gly-Ser-Arg (YIGSR), a binding motif pre-sent in the b1 chain of laminins [26].MethodsAnimalsAll ... DNA-synthesis (by 56 ±11%, P < 0.05, Figure 5C) and cell number (not shown).This inhibitory effect was fully reversed by solubleYIGSR. Surprisingly , the inhibitory effect of coatedYIGSR...