... http://arthritis-research.com/content/11/6/R180
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(page number not for citation purposes)
Vol 11 No 6
Research article
A multicenter, double-blind, randomized, controlled phase III
clinical trial of chicken type II collagen in rheumatoid ... 1
The flow sheet of production of chicken type II collagen (CCII)The flow sheet of production o...
... results of a multicenter, randomized,
double-blind, placebo -controlled, phase III trial evaluating pri-
mary efficacy and safety at twenty-four weeks. Arthritis Rheum
2006, 54:2793-2806.
10. Finckh ... respectively. Clinical trials confirmed
the efficacy in switching to abatacept (gain of effect 10.2%).
Tocilizumab allows DAS28 (DAS using 28 joint counts)
remission in 3...
... 90-day clinical study, we also
assessed the safety of 5-Loxin
®
in OA patients.
Pain, stiffness of joints, reduced joint movement and physical
disability are the major clinical manifestations of ... analysis
Analysis Details
Serum biochemistry Albumin
Alkaline phosphatase
Total bilirubin
Cholesterol
Creatinine
Creatine kinase-N-acetyl cysteine
Glucose
High-density lipoprotein
Low-...
... groups. Following 24 hours of
administration of IV ibuprofen, no clinically significant differences in any safety parameter including renal function or
bleeding occurred through the 28-day follow-up ... 14:R125
http://ccforum.com/content/14/3/R125
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In a secondary analysis of efficacy, the efficacy of IV
ibuprofen was analyzed by assessing the percentage of
treatm...
... standard.
RESULTS
Induction of citral lyase
Initially, the reproducibility of the results was hindered by
variations in the citral lyase activity of the P. digitatum
spores. Remarkably, lyase activity was ... citral lyase could be induced in the nonger-
minating spores of P. digitatum. To the best of our
knowledge, the induction of an enzymatic activity in
nongerminating spo...
... phosphotyrosines
bind to the phosphotyrosine binding pocket of the SH2
domain, with R94 only playing a minor role in the
binding of these peptides.
DISCUSSION
The cytoplasmic part of the EpoR contains ... tyrosines in the context of SOCS-binding we deter-
mined binding affinities of SOCS-3 to peptides containing
only phosphotyrosine pY429 or pY431, as well as a double-
phosphoryl...
... analyzed off-line in a Biflex III (Bruker
Daltonics, Bremen, Germany) MALDI-TOF instrument
in positive ion mode as described previously [6]. External
calibration was performed using angiotensin II ... of
birtoxin (Fig. 4). In ikitoxin the presence of Glu23 charge
preceding the a-helix modifies the activity of this toxin in a
unique way to result in reduced potency in mice....
... Int. J. Med. Sci. 2008, 5
67
such as dihydroxyvitamin D3 (calcitriol), that increase
PSADT without concomitantly decreasing PSA and yet
become clinically valuable when used in combination ... months and 11 continued for
at least 1 year with one patient continuing for more
than 2 years. Therapy was not discontinued in any
patient due to vitamin toxicity or for other safety
reasons...