Báo cáo khoa học: "Infectious salmon anaemia virus (ISAV) isolated from the ISA disease outbreaks in Chile diverged from ISAV isolates from Norway around 1996 and was disseminated around 2005, based on surface glycoprotein gene sequences" potx

Tài liệu Báo cáo khoa học: Progress for dengue virus diseases Towards the NS2B–NS3pro inhibition for a therapeutic-based approach ppt

... Journal compilation ª 2007 FEBS 3001 REVIEW ARTICLE Progress for dengue virus diseases Towards the NS2B–NS3pro inhibition for a therapeutic-based approach Sonia Melino and Maurizio PaciDepartment ... agendas of the World Health Organization and of national ministriesof health and military organizations. An alternative to vaccines is found in therapeutic-based approaches. Understanding the ... Chanprapaph S, Saparpakorn P, Sangma C, Niyomrat-tanakit P, Hannongbua S, Angsuthanasombat C &Katzenmeier G (2005) Competitive inhibition of the dengue virus NS3 serine protease by synthetic...

Báo cáo khoa học: Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle ppt

... preparation. Of particular importance is the ﬁnding that exogenous cADPR failed to increase the spontaneous release of ATP in the absence of CD38. In other words, the presence of CD38 is mandatoryfor the ... enhanced the spontane-ous release of ATP but not the release of ATP evokedby action potential ﬁrings. The enhancing effect of cADPR on spontaneous release of ATP was: (a) unaf-fected by inhibition ... of ATP. Further studies are needed to determine the mechanisms of purine-mediated presynaptic neuromod-ulation in the bladder. The enhancing effect of cADPR on the spontaneous release of ATP...

Báo cáo khóa học: Selective release and function of one of the two FMN groups in the cytoplasmic NAD + -reducing [NiFe]-hydrogenase from Ralstonia eutropha pptx

... averages of three measurements.Ó FEBS 2004 Two FMN groups in NAD + -reducing [NiFe]-hydrogenase (Eur. J. Biochem. 271) 805 Selective release and function of one of the two FMN groups in the cytoplasmic ... demonstrate that the release or re-binding of ﬂavin at the FMN- a binding site occurs only in reduced enzyme and that FMN- a is essential for the NADH-induced activation of the Ni-Fe site in the SH, as well ... contain FMN- a.Integrity of the SH during the release of FMN- aOur experiments show that both the extent of the drop in activity as well as the amount of released FMN weredependent on the enzyme...

Báo cáo khoa học: Contributions to catalysis and potential interactions of the three catalytic domains in a contiguous trimeric creatine kinase doc

... interactions to inhibit the binding and closing of any other activesites that are in communication with the closed site, issimple and appealing and goes some distance towardsexplaining the asymmetry ... onlyone of a set of interacting active sites to complete a catalytic cycle at a time. Further understanding of catalysis and the interaction of active sites in theseunique contiguous trimeric ... trimeric creatine kinase FEBS Journal 275 (2008) 646654 ê 2008 The Authors Journal compilation ê 2008 FEBS 653 Contributions to catalysis and potential interactions of the three catalytic domains in...

Báo cáo khoa học: Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of a hemeregulated phosphodiesterase from Escherichia coli pptx

... DosH as a template and using the following respective 5Â-sense primers: 5Â-gatgagtcgggagACCcagctggagaaaaaag-3Â,5Â-gatgagtcgggagTTTcagctggagaaaaaag-3Â,5Â-ggacccgttttgcgACCtcgaaagtgagc-3Â, and ... compilation ê 2006 FEBS 1213 Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of a heme- regulated phosphodiesterase from Escherichia coli Nao ... decreased the rate of auto-oxidation [5],whereas Ala and Asn substitutions at Asp40, anamino-acid residue that interacts via two water mole-cules with the proximal ligand His77, markedlyincreased...

Báo cáo khoa học: Initiation of JC virus DNA replication in vitro by human and mouse DNA polymerase a-primase ppt

... replication of aplasmid carrying the JCV origin. Columns 2 and 3, SV40 Tag with human and murine DNA polymerase a-primase, respectively; columns4 and 5, JCV Tag with human and murine DNA polymerase ... driven by murine comparedwith human DNA polymerase a-primase. In order toFig. 1. DNA replication assays in murine FM3A cell extracts depleted of DNA polymerase a-primase using the SV40 (A) and JCV ... origin (A); the JCV system con-tains JCV TAg and DNA with the JCV rep-lication origin (B). DNA polymerase (0.25 and 0.5 U) of the indicated DNA polymerase a-primase complexes were added (H4, human, columns...

Báo cáo khoa học: Mycobacterium tuberculosis ClpC1 Characterization and role of the N-terminal domain in its function ppt

... action of theseproteins in M. tuberculosis. In this study, we functionally characterized the ClpC1 protein of M. tuberculosis, and investigated the role of its N-terminal repeats in its activity. ... additional N -domain, homologousto the N-domains of ClpA or ClpB, and a linker domain homologous to, but half the size of, the linker domain of ClpB [19]. The N-terminal regioncontains two 32-amino acid ... Deletion of N-terminal conservedrepeat I along with the intervening amino acids linkingit to N-terminal conserved repeat II did not affect the conformation of ClpC1 and the resultant protein,ClpC1D2,...

Báo cáo khoa học: Functional transitions of F0F1-ATPase mediated by the inhibitory peptide IF1 in yeast coupled submitochondrial particles pdf

... investi-gated in submitochondrial particles by studying the IF1- mediated ATPase inhibition in the presence and absence of a protonmotive force. In the presence of protonmotiveforce, IF1 added during ... shown in Fig. 3B. Curve 3 (dashed) was obtained by mul-tiplying ordinates of curve 1 by the ratio between uncoupled and coupled GTPase rates in the absence of IF1. It indicates expected uncoupled ... consider the other sites; a completedescription of the enzyme should take into account the increase of nucleotide occupancy induced by IF1 [43,44]). The statements are the following: The ADP-loaded...

Báo cáo khoa học: Par j 1 and Par j 2, the two major allergens in Parietaria judaica, bind preferentially to monoacylated negative lipids potx

... 2009 FEBS Par j 1 and Par j 2, the two major allergens in Parietaria judaica, bind preferentially to monoacylated negative lipids Roberto Gonza´lez-Rioja 1 , Juan A. Asturias 1 , Alberto Martı´nez 1 ,Fe´lix ... recombinant Par j 1 and Par j 2 expressed in Pichia pastoris (rPar j 1 and rPar j 2, respectively). Very similar spectra areobtained for rPar j 2 and natural Par j 1 Par j 2, showing a minimum at ... of the mostcommon causes of pollinosis [24]. The two major aller-gens of P. judaica, Par j 1 and Par j 2, have beencloned and sequenced, and their recombinant counter-parts were able to induce...

Báo cáo hóa học: " Infectious salmon anaemia virus replication and induction of alpha interferon in Atlantic salmon erythrocytes" potx

... CentralPage 1 of 12(page number not for citation purposes)Virology JournalOpen AccessResearch Infectious salmon anaemia virus replication and induction of alpha interferon in Atlantic salmon erythrocytesSamuel ... (elu-tion and uptake) of the ISAV-induced haemagglutination of Atlantic salmon erythrocytes between virus strains of differing pathogenicities. We found remarkable differ-ences in virus replication and ... isolates of infectious salmon anaemia virus correlates with genetic var-iation of the viral haemagglutinin gene. J Gen Virol 2001,82:2869-2879.35. Øye AK, Rimstad E: Inactivation of infectious salmon...

Báo cáo khoa học: "Influences of DTC and zinc supplementation on the cellular response restoration in restrained mice" docx

... differentiation and maturation of thymocytes [5,7]. The purpose of the present study was to determine the ability of DTC in combination with zinc supplementation torestore the cellular immune response ... effect of DTC on the two lymphaticorgans. The effects of DTC with zinc ions interaction on mitogen-induced proliferation o thymocytes in restrained miceAs shown in Fig. 1 and 2, restraint stress ... in vitro with Con A, buttotally prevents the suppressive effect of stress on the proliferative response of thymic cells to PHA. The combination of zinc ions and DTC not only counteracted the...

Báo cáo khoa học: " Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines" pot

... [3], loratadine alone results in Chk1 activation leading to an increase in the percen-tage of cells in the G2/M phase of the cell cycle. Since the G2/M phase of the cell cycle is one of the most ... determinedby dividing the density of the released DNA band by the density of the total DNA in the l ane (the released DNAband plus the unreleased DNA remaining in the well). Cell Cycle Analysis The ... to radiation alone, the loratadine- treated irradiated cells hadreturned to a more normal cell cycle distribution within18 hours of the removal of loratadine. Effect of Loratadine on Cell Cycle- associated...

Báo cáo y học: "Infectious salmon anaemia virus (ISAV) isolated from the ISA disease outbreaks in Chile diverged from ISAV isolates from Norway around 1996 and was disseminated around 2005, based on surface glycoprotein gene sequences" pptx

... citation purposes)Virology JournalOpen AccessResearchInfectious salmon anaemia virus (ISAV) isolated from the ISA disease outbreaks in Chile diverged from ISAV isolates from Norway around 1996 ... estimated the Chile isolates diverged from Norway isolates around 1996, and follow-ing a recombination event (insertion event) in the F gene around 2005, were quickly disseminated throughout the Atlantic ... protein. The amino acid sequence corresponding to the fusion protein of the Chilean ISAV in this disease outbreak is highlighted in yel-low. The designation of amino acid inserts IN1 , IN2 , and IN3 ...

báo cáo khoa học: " An extensive (co-)expression analysis tool for the cytochrome P450 superfamily in Arabidopsis thaliana" docx

... not for citation purposes)BMC Plant BiologyOpen AccessResearch article An extensive (co-)expression analysis tool for the cytochrome P450 superfamily in Arabidopsis thalianaJürgen Ehlting1, ... plantmetabolism, and to reveal functions of "orphan" P450 enzymes. An extensive and sustained annotation of the P450 genes in sequenced organisms, including plants, is being carriedout and has ... genomics of Arabidopsis P450s http:/ /arabidopsis -p450. biotec.uiuc.eduPlaCe Arabidopsis cytochrome P450 http://www .p450. kvl.dk /p450. shtmlKrochko P450s in plants http://members.shaw.ca/P450sinPlantsGeneral...

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