Báo cáo khoa học:" Protein intrinsic disorder and influenza virulence: the 1918 H1N1 and H5N1 viruses" docx

... molecules and increase the virulence of both the H5N1 and the 1918 H1N1 viruses. The results help explain many puzzling features of the H5N1 and the 1918 H1N1 viruses.Summarizing, HA (and especially ... erainclude the Spanish influenza (H1N1, 1918) , the Asian influenza (H2N2, 1958), and the Hong Kong influenza (H3N2, 1968) [3-6]. The human tolls resulting from the pandemics have been very large. The ... purposes)Virology JournalOpen AccessResearch Protein intrinsic disorder and influenza virulence: the 1918 H1N1 and H5N1 virusesGerard Kian-Meng Goh*1,4, A Keith Dunker1 and Vladimir N Uversky*1,2,3Address:...

Báo cáo khoa học: "Protein intrinsic disorder and influenza virulence: the 1918 H1N1 and H5N1 viruses" doc

... than the 1918 H1N1 and H5N1 have no pre-dicted disorder at the tip of the stalk. Examples of thisbehavior are H3N2 and the particular strain of H7N3.H9N2 and 1918 H1N1: masking the virulence The ... helix of the HA stalk (near the residues 68–79, see Figures 1 and 2). This is the case for the 1918 H1N1 strain and for all the virulent samples of the H5N1 and H9N2 subtypes. Although the similarity ... erainclude the Spanish influenza (H1N1, 1918) , the Asian influenza (H2N2, 1958), and the Hong Kong influenza (H3N2, 1968) [3-6]. The human tolls resulting from the pandemics have been very large. The...

Báo cáo khoa học: Protein folding includes oligomerization – examples from the endoplasmic reticulum and cytosol doc

... problems and follows the same basic folding rules in the cytosol and ER. The chaperones that assist the nascent chains in these twocompartments are related: members of the Hsp70 fam-ily and their ... increase in protein synthesis can result in overload of the ER foldingcapacity and the accumulation of unfolded and mis-folded proteins. The ER contains sensors that detectwhether the folding ... folding,they may restrict the ﬂexibility of the polypeptide,giving directionality to the folding process, and mayprovide additional stability to the folded protein. Oncefolded proteins have left the...

Tài liệu Báo cáo khoa học: A knowledge-based potential function predicts the speciﬁcity and relative binding energy of RNA-binding proteins ppt

... better than the reduced atomapproach. The protein RNA score has distinctive propertiescompared to the protein DNA potential. When wescored the protein RNA decoy set using the protein S. Zheng ... of groupsfor the prediction of protein structures, protein DNA and protein ligand interactions [18–35], such anapproach has never been applied to protein RNAinteractions.In the present study, ... Some of these mutations arenot near the protein RNA interface (e.g. one of the U1A mutations, D79V, is 9 A˚from the RNA mole-cule), and only the use of a longer cut-off value cancapture these...

Báo cáo khoa học: "A Preference-first Language Processor Integrating the Unification Grammar and Markov Language Model for Speech Recognition-ApplicationS" potx

... hypotheses and significantly reducing the search space. Therefore the global structural synthesis capabilities of the unification grammar and the local relation estimation capabilities of the ... the unification grammar and the Markov language model will be integrated in the language model to obtain better results. The parsing strategy 1 uses the random selection principle and the ... ambiguity and large number of noisy word hypotheses in the word lattices usually make the search space huge and correct identification of the output sentence hypothesis difficult, and the capabilities...

Báo cáo khoa học: Treatment with small interfering RNA affects the microRNA pathway and causes unspeciﬁc defects in zebraﬁsh embryos doc

... containing the RNase III enzyme Drosha and the dsRNA-binding protein DGCR8, cleaves the pri-miRNA and exises astem loop of  70 nucleotides [3–6]. This precursormiRNA (pre-miRNA) is then exported to the cytoplasm ... containingArgonaute proteins as well as Dicer and other factors[3]. One of the additional factors is TRBP, whichtogether with Dicer facilitates generation of siRNAs and mature miRNAs from dsRNAs and pre-miRNAs,respectively ... to the same GFP sequence. Single-stranded and double-stranded molecules without the characteristicfeatures of siRNA did not affect the level of miR-430b, as com-pared to non-injected (WT) and...

Báo cáo khoa học: Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1 pot

... form the outsideof the wedges. The wedge pockets have an extended seamthat extends the length of the interface between thesedomains with the c-phosphate of bound ATP exposed atone end. On the ... activity by elevation of the NADH/NAD+ and acetyl-CoA/CoA ratios. In the PDC reaction(forward direction proceeds in the counterclockwise direction), the rapid and reversible E3 and E2 reactions respond ... how the foremost changes in the kinase and phosphatase activitiesissue from the dynamic, effector–modified interactionsof these regulatory enzymes with the flexibly held outerdomains of the core-forming...

Báo cáo khoa học: Protein transport in chloroplasts ) targeting to the intermembrane space pptx

... mem-brane and the photosynthetic thylakoid membranes) aswell as three soluble subcompartments, the thylakoidlumen, the stroma and the intermembrane space. The large majority of chloroplast proteins ... [35S]pTic22, [35S]pMGD1 and [35S]pSSU were added to the column in binding buffer and incubated for 45 min. The ﬂowthrough after incubation (Ft), the third wash of the matrix (W) and the elution with ... from the Tic translocon and is redirected to the outer envelope [13]. Toc75itself could play a role in the insertion of the outerenvelope protein OEP14 [14].In the present study, we describe the...

Báo cáo khoa học: Inﬂuence of divalent cations on the structural thermostability and thermal inactivation kinetics of class II xylose isomerases pdf

... XIs from the mesophiles E. coli (ECXI) and Bacillus licheniformis (BLXI), for the moderatethermophile Thermoanaerobacterium thermosulfurigenes(TTXI), and for the hyperthermophile Thermotoganeapolitana ... coli and Bacillus licheniformis),thermophilic (Thermoanaerobacterium thermosulfurigenes), and hyperther-mophilic (Thermotoga neapolitana) bacteria were examined. Unlike the three less thermophilic ... bands, presumably the tetramer,dimer, and monomer (Fig. 5). In comparison, in the presence of a single metal, no soluble protein was pre-sent at temperatures beyond the end of the single ther-mal...

Báo cáo khoa học: "Effects of mosapride on motility of the small intestine and caecum in normal horses after jejunocaecostomy" potx

... (A) and the control group (B). *,†Significant differences (p ＜ 0.05, p ＜ 0.01) comparedbetween the treated group and the control group on the same day.than those in the control group, the ... distributed in the ileum and pelvic flexure [16]. Therefore, it is suggested that the difference in the distribution of the 5HT4 receptor is at the base of different effects of mosapride in the small ... horses after celiotomy and jejunocaecostomy. Therefore, the purpose of the present study was to evaluate the effects of mosapride on motility of the small intestine and caecum in horses after...

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