... time in 1977 in Jamaica and rapidly spreading to the Antillesincluding Cuba, Antigua & Barbuda, Aruba, Bahamas,Barbados, Curaçao, Dominica, Grenada, Guadaloupe,Guyana, Haiti, Martinique, ... serotypes have been associated with severe disease. To date, DENV-1 falls into five cladesdesignated as genotype I (Southeast Asia, China andEast Africa), genotype II (Thailand), genotype III(Malaysia), ... clock In addition, estimated rate of evolutionary change (nucleo-tide substitutions per site per year) and tree root age wasobtained with the program BEAST (Bayesian EvolutionaryAnalysis by Sampling...