Báo cáo y học: " Complete coding sequence characterization and comparative analysis of the putati" docx
Báo cáo y học: " Complete coding sequence characterization and comparative analysis of the putati" docx
... sequence alignment and drafted the manuscript. SP and KS participated in the sequence alignment. PL and YP participated in the design of the study and performed the data statistical analysis. YP conceived of the ... iden-tity with HRV-A and HRV-B, respectively. Directinvestigation of the VP1 gene revealed that HR V-CU072shared only 64% sequence identity with the other HRV-Cs.HRV-CU072 coding sequence analysis To ... windows.Results Complete coding sequence analysis The entire coding sequences of the 6 additional HRVstrains elucidated in this study have been submitted to the GenBank database and assigned accession...
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Báo cáo y học: "oronary artery bypass surgery and longitudinal evaluation of the autonomic cardiovascular function" pps
... Task Force of the EuropeanSociety of Cardiology and the North American Society of Pac-ing and Electrophysiology. Circulation 1996, 93:1043-1065.7. Eagle KA, Guyton RA, Davidoff R, Ewy GA, Fonger ... similar in the healthy, CAD and CABG groups before sur-gery and remained constant during the 90 days of follow-up in the CAD group. In the CABG group, both forced expiratoryvital capacity and peak ... variability (HRV), respiratory sinus arrhythmia (RSA), and Valsalva maneuver.Results After CABG there was a decrease in, and a later recovery of, (1) the HRV in the time domain and in the frequency...
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Báo cáo y học: "Genome-wide expression profiling and bioinformatics analysis of diurnally regulated genes in the mouse prefrontal cortex" pps
... the liberal FDR threshold used in ourstudy, some of these genes may serve as candidates for stud-ying the role of prefrontal cortex in the regulation of circadianrhythm, diurnal activity and ... each of the 546 transcription factor PWMs, define over-representation of the PWM xi as:where |P| and |C| are the number of sequences in P and C,respectively. Let P' be a set of |P| sequences, ... contributionsSY performed microarray experiments, real-time PCR valida-tion, raw data processing and clustering analysis. KW and OVconducted bioinformatics analysis on the diurnal genes and comparative analysis...
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Báo cáo y học: " Correlation between nucleotide composition and folding energy of coding sequences with special attention to wobble bases" docx
... might behypothesized that the presence of a rare codon, marked by the synonymous polymorphism, affects the timing of co-translational folding and thereby alters the structure and function of expressed ... statistical analysis of the results.Results and discussionFolding free energy of coding sequencesThere is disagreement in the literature regarding the posi-tional (free) folding energy of coding sequences. ... they arenot expected to change the function of the protein inwhich they occur. However, they often do. SynonymousSNPs in the Multi-drug Resistance 1 (MDR1) gene alter the conformation of the...
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Báo cáo y học: "A third-generation microsatellite-based linkage map of the honey bee, Apis mellifera, and its comparison with the sequence-based physical map" pps
... progeny of V. The probability of a single UDC was 0.011 and that of more than one UDC was 6.10-5 in the B progeny and 0.176 and 0.021, respectively, for the progeny of V. Consequently, the true ... in the assembly (as for the otherspecies) and their addition could create a plateau.Nevertheless, the proximity of the centromere seems to havelittle, if any, effect (Figure 4). The Marey maps ... betweenthem. On the basis of extensive analysis of mammaliangenomes, these authors rejected the theory that recombina-tion may be related to fecundity. It has to be noted that if the hypothesis had...
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Báo cáo y học: "n Ambystoma mexicanum EST sequencing project: analysis of 17,352 expressed sequence tags from embryonic and regenerating blastema cDNA libraries" pot
... whereby an E-value of 1e-20 was used for sig-nificant similarity and an E-value of 1e-05 was used as a cutoffvalue for weak similarity. Analysis and assembly of sequence dataQuality control of sequenced ... sequence alignment of the amino-terminal, CDK-inhibitory region of the CKI families. The protein sequence of A. mexicanum p27 is clearly the ortholog of the p27 family, yet displays higher than ... com-pare members of the cyclin B family - cyclins B1, B2 and B3. The sequences of each family member formed strictly sepa-rate groups, with the A. mexicanum and X. laevis cyclin B1,B2 and B3 genes...
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Báo cáo Y học: Propionate CoA-transferase from Clostridium propionicum Cloning of the gene and identi®cation of glutamate 324 at the active site pdf
... puri®ed and the gene encoding the enzyme has beencloned and sequenced. The enzyme was rapidly and irre-versibly inactivated by sodium borohydride o r h ydroxyl-amine in the presence of propionyl-CoA. ... (DSMZ, Braunsc hweig,Germany).Synthesis of acyl-CoA substratesAcetyl-, butyryl- and propionyl-CoA were prepared from the corresponding anhyd rides and CoA by the method of Simon & Shemin [18]. ... excised from the vector and the inserts were sequenced using standardlaboratory protocols. The sequence data w ere analysedusing the EXPASY(Expert Protein Analysis System) server of the Swiss...
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Báo cáo y học: "Commentary on “Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus”, by RR Graham et al" pdf
... been published, and, despite the relatively small sizes of the individual studies and the ethnic heterogeneity of the populations studied,there appears to be a surprising degree of overlapbetween ... Gray-McGuire C, Moser KL, Gaffney PM, Kelly J, Yu H, Olson JM,Jedrey CM, Jacobs KB, Kimberly RP, Neas BR, Rich SS, BehrensTW, Harley JB: Genome scan of human systemic lupus erythe-matosus by ... This commentary discusses theirapproach and identifies lessons that may be applicable to the investigation of other complex diseases.Keywords: association, linkage, systemic lupus erythematosus,...
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Báo cáo y học: "A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee" potx
... inserum and haematological parameters, and urine analysis wereperformed to evaluate the safety of 5-Loxin® in OA patients.Results Seventy patients completed the study. At the end of the study, ... properties byinhibiting the 5-lipoxygenase enzyme. A 90-day, double-blind,randomized, placebo-controlled study was conducted toevaluate the efficacy and safety of 5-Loxin® in the treatment of osteoarthritis ... walkAvailability for the duration of the entire study periodExclusion History of underlying inflammatory arthropathy or severe rheumatoid arthritisHyperuricaemia (>440 μmol/l) and/ or past history of...
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Báo cáo y học: " A global survey identifies novel upstream components of the Ath5 neurogenic network" pdf
... subdomains of the eye.To assess the relevance of the findings in the context of anembryo, we carried out functional assays in vivo and foundthat 9 out of 12 genes tested by clonal analysis in the ... expression of the Ath5 reporter (green), making the analysis independ-ent of the total number of Ath5 positive cells. We thus deter-mined the in vivo activity of the different candidates in the generation ... vertebrates.BackgroundGene regulatory networks (GRNs) determine the animal bodyplan and cooperate to specify the different cell types of the organism. They have evolved to integrate and precisely con-trol developmental...
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