báo cáo khoa học: " Medicines and vaccines for the world''''''''s poorest: Is there any prospect for public-private cooperation?" ppt

báo cáo khoa học: " Medicines and vaccines for the world''''s poorest: Is there any prospect for public-private cooperation?" ppt

... of 8(page number not for citation purposes)Globalization and HealthOpen AccessReview Medicines and vaccines for the world's poorest: Is there any prospect for public-private cooperation?Richard ... margin for the Fortune 500 drug firms has consistentlyexceeded the margin for all Fortune 500 companies takentogether. It is possible that the higher profits are compen-sation for higher risk ... market is crucial important to the overallprofitability of the industry, accounting for 60% of the global profits of the industry [5]. Therefore, the needs of the US market figure prominently in the...

Báo cáo khoa học: Pressure and heat inactivation of recombinant human acetylcholinesterase Importance of residue E202 for enzyme stability pdf

... protein stability is variable, depending on theirstructural characteristic and their location on the surface[34].ANS bindingTo investigate further the description of the mechanism of the pressure ... E202 is lowerdown in the gorge next to the active serine; (c) E450 is  9A˚away; and (d) D74 is located at the entrance of the active sitegorge (Fig. 1).D74 (72) is a component of the peripheral ... [49–51]. Moreover, as for halophilic and thermophilic proteins, the apparent requirement for somany acidic groups on the surface of AChE could berationalized on the basis of their high water-binding...

Báo cáo khoa học: Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2¢ of substrates pdf

... nine random amino acids, followedby a His6-tag in the C-terminus of capsid protein 10.Thereby, the phages display a random nonamer ontheir surface, and by interactions of the His6-tag the phages ... Asp and Glu areroughly equally distributed in this position in the wild-type HC and the three HC mutants. Therefore,Arg143 and Lys192 do not distinguish between Asp orGlu, but attract these ... than the HC or the DC consensus sites. This veriﬁes its preference for Trp over Phe and Tyr at position P1 and the accu-racy of the information obtained by the phage displayanalysis.DiscussionSite-directed...

Báo cáo khoa học: A hydrophobic segment within the C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone pptx

... site exists in the C-terminal domain ofHSP90. The aim of the present study is to elucidate the regions within the C-terminal domain responsible for the bindings to the middle domain and to a ... present, it is ambiguous whether this discrepancy is causedby the variation in the binding sites of HSP90 for the respective substrates or if the respective regions are respon-sible for certain ... regionincluding the hydrophobic segment of the C-terminaldomain is essential for both the client binding and dimerformation of the HSP90-family molecular chaperone and that the dimeric conﬁguration...

báo cáo khoa học: "Nanofibers and nanoparticles from the insectcapturing adhesive of the Sundew (Drosera) for cell attachment" ppsx

... that the contact area between the tip and the adhesive was less than 78.5 nm2, the elasticity of the Sundew adhesive is quite large. Since the maximum ver-tical withdraw distance setting for the ... cells/mm2 for the negative control, 1681 cells/mm2 for the positive control, and 1253 cells/mm2 for the Sundewadhesive coated surface. Due to the non-uniformity i n the coating of the Sundew ... accharide, and organicnanoparticles), and the porous network structure of the nanofibers, led to the hypothesis that the network couldbe used for applications in tissue engineering and wound...

báo cáo khoa học: "Structure and expression of the maize (Zea mays L.) SUN-domain protein gene family: evidence for the existence of two divergent classes of SUN proteins in plants" pot

... detectable band pat-terns. These high-molecular-weight bands were notdetected in the protein samples examined for multipleother, different, nonanther tissues (Figure 8B). The basis for this difference ... performed the Solexa mRNA transcription profiles for ZmSUN1-5 and GAPDH . SPM and HWB and CRS interpreted the results, and SPM and HWB wrote the manuscript.All authors read and approved the ... plants and moss and therefore probably originated early in plant evo-lution, if not before that. The discovery of this gene familyopens new avenues for investigation of molecular mechan-isms...

báo cáo khoa học: " Globalization and Health: Exploring the opportunities and constraints for health arising from globalization" pot

... Over the rel-atively short period of the last 5 to 8 years, many newplayers have emerged on the global scene with additionalfunding and their own sets of priorities for investing inhealth and ... UnitedNations players like the WHO, World Bank and UNICEFhave changed their focus. We will stimulate discussionabout how best to enhance the prospects of improvinghealth at the local and national level ... Publish with Bio Med Central and every scientist can read your work free of charge"BioMed Central will be the most significant development for disseminating the results of...

Tài liệu Báo cáo khoa học: Investigation and prediction of the severity of p53 mutants using parameters from structural calculations pptx

... 34% for MDM2, 71% for NOXA and 61% for p53R2, and around 45% for the other four promot-ers. For some speciﬁc mutants, the differences in activityare very large (Table 10). These mutants are thereforeexpected ... use these residues for binding or that they are not necessary for binding as the DNA binds sufﬁciently hard to the other DNA bindingresidues. For the WAF1 and MDM2 promoters, the sit-uation is ... ÀxðÞ2Py ÀyðÞ2qwhere x and y are values from the two parameters mea-sured, and x and y are the mean values for the respectiveparameters.Thermally sensitive mutants There are several p53 mutants...

Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx

... Thus, the apoptotic volumedecrease may further disarrange the balance betweensurvival and death signals, thereby promoting execu-tion of the apoptotic program.Concluding remarksIt is well ... stimulate a rapid osmolyte uptake that is important for mitogenesis [16]. For example, a rapid and transient Na+ and amino acid inﬂux is essential for the mitogenic response of 3T3 ﬁbroblasts ... involved in the regulationof metabolism, gene expression and the susceptibilityto different kinds of stress [6]. For example, the inhibi-tion of autophagic proteolysis by insulin, glutamine and ethanol...

Tài liệu Báo cáo khoa học: "Names and Similarities on the Web: Fact Extraction in the Fast Lane" ppt

... which the candidate fact is extracted; and c) the pattern-based scores of the candidate fact. The latter fea-ture converts the scores of the patterns extracting the candidate fact into a score for ... facts. This is the case for the first five candidate facts in Figure 3. For ex-ample, the first word Richard from one of the can-didate facts is similar to the first word John fromone of the seed ... index-able.Based on the sample set, the average preci-sion of the list of one million facts extracted fromchunk W1 is 98.5% over the top 1/100 of the list,93.1% over the top half of the list, and 88.3%...

Xem thêm