báo cáo khoa học: " Improving clinical research and cancer care delivery in community settings: evaluating the NCI community cancer centers program" docx

Tài liệu Báo cáo khoa học: Substrate speciﬁcity and inhibition of brassinin hydrolases, detoxifying enzymes from the plant pathogens Leptosphaeria maculans and Alternaria brassicicola ppt

... 2009 The Authors Journal compilation ê 2009 FEBS 7415 Substrate specificity and inhibition of brassinin hydrolases, detoxifying enzymes from the plant pathogens Leptosphaeria maculans and Alternaria ... determined from the slope ()Ea⁄ R) of Arrheniusplots of log V (nmol of product per minute) versus1 ⁄ T. Substrate specificity The substrate specificity of BHs was determined using the synthetic ... (Leptosphaeria maculans and Leptosphaeria biglobosa) and blackspot (Alternaria brassicicola) fungi are devastating plant pathogens knownto detoxify the plant defence metabolite, brassinin. The...

Báo cáo khoa học: Protein–protein interactions and selection: generation of molecule-binding proteins on the basis of tertiary structural information potx

... The Authors Journal compilation ê 2010 FEBS 2013 MINIREVIEW Protein–protein interactions and selection: generation of molecule-binding proteins on the basis of tertiary structural information Mitsuo ... candidate location in NCS for grafting with the CDR 3 loop of VHH. (B) Insertion of the CDR 1-containing loop of the heavy chain in Fv into the candidate location in TOP. Generation of binding proteins ... or NMR structural analyses and the construction of artiﬁcial libraries allow con-structive selection and functionalization not only of antibody fragments, but also of small, nonantibodyproteins...

Báo cáo khoa học: Insights into substrate and product trafﬁc in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel ppt

... Journal compilation ª 2008 FEBS 2661 Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel Florian Nachon1, ... not inhibit substrate hydrolysisbecause the traffic can pass via an alternative route, presumably the enlarged back channel. AbbreviationsCAS, acylation site; DmAChE, Drosophila acetylcholinesterase; ... efficiency of the alternative routecompared to the main entrance, or to a partial overlapof the side chain of propidium and a atoxin with the active site as it may span into the gorge. Experimental proceduresProtein...

Báo cáo khoa học: Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling docx

... regulatory and ⁄ or substrate proteins and areintegrated into cell signalling pathways and cell cycleevents [23]. The UD, Src homology 3 and Src homology 2 (SH2) domains in Src are key bindingsites ... a Src SH2binding protein. We observed that MVP interactswith Src in mammalian cells and inhibits the activityof Src tyrosine kinase.ResultsIsolation of MVP as Src SH2 interacting protein by ... of Src in normal and trans-formed cells [22]. Compelling evidence indicates that Src- binding proteins can regulate Src activity [23].While a number of interacting proteins that upregu-late Src...

Báo cáo khoa học: Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans docx

... pos-sess solanesyl and decaprenyl diphosphate synthases as the determiningenzyme for a type of ubiquinone. Here we show that murine and human solanesyl and decaprenyl diphosphate synthases ... FEBS Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans Ryoichi Saiki, Ai Nagata, Tomohiro Kainou, Hideyuki Matsuda and Makoto KawamukaiFaculty of Life and ... components of the solane-syl ⁄ decaprenyl diphosphate synthases in mice and humans, we can ask which component is more import-ant in determining the chain length of ubiquinone byreplacing either...

Báo cáo khoa học: Calcium-induced activation and truncation of promatrix metalloproteinase-9 linked to the core protein of chondroitin sulfate proteoglycans pot

... Calcium-induced activation and truncation of promatrix metalloproteinase-9 linked to the core protein of chondroitin sulfate proteoglycans Jan-Olof Winberg1, Eli Berg1, ... Ourresults indicate that the interaction between the MMP-9 and the core protein of the CSPG was the causal factor in the calcium-induced activation and truncation of the gel-atinase, and that this process ... from the CSPG through a process that appeared to be a stepwise truncation of both the CSPG core protein and a part of the C-terminal domain of the gelatinase. The calcium-induced activation and truncation...

Báo cáo khoa học: Apo a-lactalbumin and lysozyme are colocalized in their subsequently formed spherical supramolecular assembly doc

... Apo a-lactalbumin and lysozyme are colocalized in their subsequently formed spherical supramolecular assembly Michaeăl Nigen, Thomas Croguennec, Marie-Noeălle Madec and Saăd BouhallabINRA, ... the interactions) leading to different supramolecular structures [3], and for the control and orientation of protein interactions and cluster forma-tion. We are convinced that an understanding ... [21–23]. These proteins differ particu-larly in their opposing isoelectric points (the pI valueof lysozyme is 10.7, whereas that of a-lactalbumin isnear 4–5) and their calcium-binding properties...

Báo cáo khoa học: HIP/PAP, a C-type lectin overexpressed in hepatocellular carcinoma, binds the RIIa regulatory subunit of cAMP-dependent protein kinase and alters the cAMP-dependent protein kinase signalling ppt

... HIP/PAP alters PKA signalling (Eur. J. Biochem. 271) 3817 HIP/PAP, a C-type lectin overexpressed in hepatocellular carcinoma, binds the RIIa regulatory subunit of cAMP-dependent protein kinase and ... be overexpressed in human hepatocellular carcinoma (HCC)[1] and in the pancreas during acute pancreatitis [2]. HIP/PAP has been characterized as a protein belonging to the group 7 of C-type lectins ... Hepatocarcinoma-intestine-pancreas/pancreaticassociated protein (HIP/PAP) is expressed and secreted byproliferating ductules as well as by hepatocarcinoma and cho-langiocarcinoma cells. Am. J. Pathol....

Báo cáo khoa học: "Outcomes of resection and non-resection strategies in management of patients with advanced colorectal cancer" doc

... survival of patients treated with resection and non -resection Author Resection Non -resection p valueNumber of patients Median survival (months)Number of patients Median survival (months)*Scoggins ... com-pared with other interventional, non -resection, treatmentmodalities. Non -resection strategies should be offered aspart of the process of informed consent, for patients with stage IV colorectal ... cases with technical failure reported in 8% of cases and perfora-tion in 4% [12]. In this series the technique of stentingwas introduced and developed in the unit during thestudy period and in...

Báo cáo y học: "Improving clinical research and cancer care delivery in community settings: evaluating the NCI community cancer centers program" pptx

... purposes)Implementation ScienceOpen AccessMethodologyImproving clinical research and cancer care delivery in community settings: evaluating the NCI community cancer centers programSteven B Clauser*1, ... programs.Summary NCI increasingly recognizes the critical role that multi-level systems interventions will play in improving health,both in clinical research and in clinical care. Federal research institutions ... disparities in cancer care; increasing the number of patients enrolled in clinical tri-als; enhancing the site capacity in information technol-ogy; and enhancing the capacity for the site to...

báo cáo khoa học: "European health research and globalisation: is the public-private balance right?" potx

... World Health Organisation following the landmark report of the Commission on Health Research for Development[16], has revised the term to research for health in anattempt to emphasise public -health ... [EUR22700].doi:10.1186/1744-8603-7-5Cite this article as: McCarthy: European health research and globalisation: is the public-private balance right? Globalization and Health 2011 7:5.McCarthy Globalization and Health 2011, ... Globalization and Health 2011, 7:5http://www.globalizationandhealth.com/content/7/1/5Page 2 of 8 DEBATE Open AccessEuropean health research and globalisation: is the public-private balance right?Mark...

báo cáo khoa học: " Improving calculation, interpretation and communication of familial colorectal cancer risk: Protocol for a randomized controlled trial" ppt

... O C O L Open Access Improving calculation, interpretation and communication of familial colorectal cancer risk: Protocol for a randomized controlled trialNicky Dekker1,2, Rosella PMG Hermens2*, ... recognition of familial and hereditary CRC atboth the national and international level, and will serve as an example to improve care for patients and their rela-tives worldwide. Our results may also ... interpretation and communication of familial colorectal cancer risk: Protocol for a randomized controlled trial. Implementation Science 2010 5:6.Submit your next manuscript to BioMed Central and take full...

Báo cáo khoa học: "Correction: Clinical experiences and current evidence for therapeutic recombinant factor VIIa treatment in nontrauma settings" pdf

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Báo cáo khoa học: "Premortem clinical diagnoses and postmortem autopsy findings: discrepancies in critically ill cancer patients" potx

... 2ResearchPremortem clinical diagnoses and postmortem autopsy findings: discrepancies in critically ill cancer patientsStephen M Pastores, Alina Dulu, Louis Voigt, Nina Raoof, Margarita Alicea and Neil ... betweenpremortem clinical diagnoses and postmortem findings in cancer patients who died in a medical-surgical ICU at a tertiarycare cancer center. Our findings underscore the need forenhanced surveillance, ... monitoring, and treatment of infections and cardiopulmonary disorders in critically ill cancer patients.IntroductionMajor discrepancy rates between premortem clinical diag-noses and postmortem autopsy...

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