báo cáo khoa học: " Gene expression and hypoxia in breast cancer" doc

... function, contributes to an increase in free radical generation in hypoxia, increases cell survival under hypoxia, induces a switch to glycolysis in both normoxia and hypoxia, and upregulates the ... prognosis in endometrial, colorectal, head and neck and non-small-cell lung cancer [22-26], and the expression of this gene in breast cancer has been linked to HIF‑1α expression [27]. Interestingly, ... diagnosis and therapy. In this review, we outline the existing markers of hypoxia and recently identied gene and miRNA expression signatures, and discuss their potential as prognostic and predictive...

báo cáo khoa học: "Gene-expression and network-based analysis reveals a novel role for hsa-mir-9 and drug control over the p38 network in Glioblastoma Multiforme progression" ppsx

... be key in finding novel treatments. Methods: Using five independent molecular and clinical data sets with a set of computational algorithms we were able to identify a gene- gene and gene- microRNA ... range in the activity levels between groups, and the distinct difference between them.(B) P38 signaling network, the genes highlighted in blue are the genes in the P38 signaling pathway, and ... from the gene- disease network-disease thinking is in need of further evidence. A careful clinical follow-up on findings such as those presented here, combined with careful molecular investigation...

Báo cáo khoa học: "PRIORITY UNION AND GENERALIZATION IN DISCOURSE GRAMMARS" doc

... priority union in ALE with the example in (15): Source is the de- fault input, and Target is the strict input. The hierarchy we assume is the same as shown in (3) and (4). Information about ... ellipsis. In the general spirit of Priist's analysis, however, we have taken one step further down the line towards determi- ning parallelism by postulating that calculating the generalization ... plays two roles in Pr/ist's rules and we have shown how its function in calculating the value of SCHEMA can be better served by using the generalization operation instead. We turn...

Báo cáo khoa học: "Segregatory Coordination and Ellipsis in Text Generation" docx

... could be combined and coordinated too. Complex coordinations involving ellipsis and gapping are much more challenging. In multiple-distinct coordination, each conjoined clause is generated, ... complexity into the coordination pro- cess. One major task of generating coordination expression is identifying identical elements in the propositions being combined. In Func- 1221 ((pred c -and) ... tasks, identifying recurring elements in the conjoined semantic structure and delet- ing redundant elements using syntactic information. Using this model, we are able to handle coordination phenomenon...

Báo cáo khoa hoc:" Case reports and the fight against cancer" docx

... of factors including molecular studies and preclinical models in order to study disease mechanism and potential targeted therapy: the kind of clinical infor-mation that could be gained through ... an interestingclinical response to sildenafil in Waldenström's mac-roglobulinemia [10].It is without question that case reports do not replace welldesigned randomized clinical trials in ... four livingrelatives of the same patient reported by Fränkel in 1886 and found that the patient had RET mutation and that herfamily had multiple endocrine neoplasia (MEN-2) [14]. In Medicine,...

Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt

... progression, the inheritance and expression of mutant huntingtin is the primary cause ofHD. Examination o f t he regulation of individual m utanthuntingtin-affected genes such as CB1 may increase ourunderstanding ... repeat a ndrelative expression of the gene encoding mutant huntingtin(HD). Although it is known that the coding region of CB1 iscontained within a single exon in mice, rats and humans, the5¢-untranslated ... in mice and humans. Only 1–2% of genes expressed in the striatum areaffected by mutant huntingtin [18]. Mutant huntingtin and the transcription factors t hat have b een shown to physicallyinteract...

Báo cáo khoa học: "Gene expression profiling of human dermal fibroblasts exposed to bleomycin sulphate does not differentiate between radiation sensitive and control patients" pptx

... of profi-brotic chemokines and cytokines and cause skin an dpulmonary fibrosis in animal models and in the clinic[12-14]. On thi s basis, the potential of using bleomycin* Correspondence: clare.isacke@icr.ac.uk; ... TGF-beta1 and bleomycin intracellularsignaling through autocrine regulation of Smad 3 binding to theproximal promoter of the Smad 7 gene. J Cell Biochem 2006,97(5):933-939.13. Rubin P, Johnston ... bleomycin sulphate has beencharacterised. No differences between clinically radiation sensitive and control patients were detected using thisapproach.Introduction Gene expression profiling of in...

báo cáo khoa học: " Gene expression analyses in maize inbreds and hybrids with varying levels of heterosis" ppt

... differences in the expression profiling platforms. In this study we have investigated the heterosis and gene expression profiles for a set of maize hybrids with varyinglevels of parental genetic ... transcriptionalvariation observed in more genetically distant inbreds.Indeed, the intergenic space in the maize genome isknown to be highly polymorphic among inbred lines[12,28], and these structural and nucleotide ... remaining genes; only nine genes showed greater than2-fold changes outside of the parental range (Table 2 and 3). These data indicate that for the vast majority of AHP and BLP genes, the expression...

Tài liệu Báo cáo khoa học: Tissue expression and biochemical characterization of human 2-amino 3-carboxymuconate 6-semialdehyde decarboxylase, a key enzyme in tryptophan catabolism pptx

... pancreatic juice and intestine: inadequatefor role in zinc absorption. Am J Clin Nutr 35, 1–9.16 Evans GW & Johnson PE (1980) Characterization and quantitation of a zinc binding ligand in human ... 829hydrophobic index of the residues within the windowcentered on amino acids involved in metal binding, itcan be noticed that regions around His6 and His8 in the human protein are predicted ... expression occurring in kidney. In brain, no ACMSD II expression is detected, and ACMSD I is present at very low levels. Cloning of the two cDNAs in yeast expression vectors and production of the recombinant...

Tài liệu Báo cáo khoa học: Endogenous expression and protein kinase A-dependent phosphorylation of the guanine nucleotide exchange factor Ras-GRF1 in human embryonic kidney 293 cells pptx

... speciﬁcally inhibit store-operated calciumchannels and may thereby reduce the serotonin-induced sustained increase in [Ca2+]i, as has beenshown for endothelin-1-induced Ca2+increase in Rat1cells ... thedeletion of amino acids 1–225, including the Ca2+⁄ calmodulin-binding IQdomain, from Ras-GRF1 reduced both basal and serotonin-stimulatedERK1 ⁄ 2 phosphorylation. Furthermore, serotonin treatment ... cultured in DMEM containing 10%(v ⁄ v) fetal bovine serum and supplements (2 mml-gluta-mine, 100 UÆmL)1penicillin, 100 lg ÆmL)1streptomycin), at37 °C in a humidiﬁed atmosphere of 5% CO2in...

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