báo cáo khoa học: " Recent insights into the role of NF-κB in ovarian carcinogenesis" pot
báo cáo khoa học: " Recent insights into the role of NF-κB in ovarian carcinogenesis" pot
... AB: Recent insights into the role of NF-κB in ovarian carcinogenesis. Genome Medicine 2010, 2:56.Alvero Genome Medicine 2010, 2:56 http://genomemedicine.com/content/2/8/56Page 3 of 3 in the ... pathway.AbbreviationsEOC, epithelial ovarian cancer cells; IKKα, inhibitor of NF-κB kinase α; IKKβ, inhibitor of NF-κB kinase β; IκB, inhibitor of NFκB; IL, interleukin; NF-κB, Nuclear factor kappa-light-chain-enhancer ... several EOC cell lines, Hernandez et al. [16] showed that inhibition of the NF-κB pathway through specific inhibition of inhibitor of NF-κB kinase β (IKKβ) can decrease the percentage of viable CAOV3,...
- 3
- 260
- 0
Tài liệu Báo cáo khóa học: Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b pdf
... cytochrome b protein was detectable in the CKL57 strain. We do not know whether the lack of immunoreactivity in the latter strain was due to the inability of the truncated protein to insert into and be ... compared to the wild-type strain. In the case of the VZ9 strain, this was to be expected, based on the reduced growth rate of the single deletion strain lackingsubunit 9. The remaining double ... 1211Interestingly, the absence of subunit 6 also resulted in anincrease in the ratio of intermediate to mature cyto-chrome c1and a disappearance of the intermediate form of the Rieske protein....
- 10
- 517
- 0
Báo cáo khoa học: Recent insights into cerebral cavernous malformations: the molecular genetics of CCM pot
... mutation was detected in the six remaining lesions.Several hypotheses may be raised to explain thisabsence of mutation including the incomplete sensitiv-ity of this type of approach which would ... com-plete loss of any of the three CCM proteins within endothelial cells lining the cavernous capillary cavities. These data were an important step towards the elucidation of the mechanisms of this ... towards the understanding of the mechanisms of this disorder. Thisminireview summarizes the advances in CCM molecu-lar genetics and the remaining gaps in this field. In addition to the identification...
- 6
- 356
- 0
Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx
... family of kinases that are thoughtto act upstream of the mitogen-activated protein kinas-es (see the accompanying minireview [11] on the bio-chemical interactions of the CCM proteins).Furthering ... phenotype. The myocardium proliferates to anormal number of cells, but instead of building into concentric layers to form the walls of the heart, the myocardial cells form into a single layer, resulting ... helptranslate the cellular and biochemical insights into a better understanding of disease mechanism. In this minireview, we discuss the contributions of animal models to our growing understanding of the...
- 8
- 416
- 0
Tài liệu Báo cáo khoa học: Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria ppt
... of binding of E-64 with ervatamin-A andervatamin-C The modes of binding of E-64 with ervatamin-A andervatamin-C have been analyzed and compared with the structures of other complexes of the ... family.E-64 binds to these two ervatamins in the same man-ner as that found in other structures of complexes of papain-like cysteine proteases, and here also the binding is in the reversed orientation ... solvent(Fig. 2B). On the other hand, the P3 moiety of E-64 in each of the of the two ervatamin-C molecules in the asymmetric unit mainly interacts with His61 in bothmolecules (Fig. 2B). The substrate...
- 14
- 634
- 0
Báo cáo khoa học: New insights into the functions and N-glycan structures of factor X activator from Russell’s viper venom pot
... found in the sequences of crotalid factor IX/X-bindingproteins; instead, they contained basic residues at theseABFig. 4. Sequence alignments of RVV-X lightchains with other factor IX/X-binding ... glycine/NaOH (pH 9–11). The remaining activity of 5 ng of RVV-X was determined bymeasuring the clotting time on a coagulation analyser.Biotinylation of RVV-X and far-western blotting The BiotinTagÔ ... binding receptors on plate-lets and endothelial cells. The important role of theseglycans in pharmacokinetics has been demonstrated by the slower and smaller increment of FDP in vivo afterthe...
- 15
- 562
- 0
Báo cáo khoa học: New insights into the P-glycoprotein-mediated effluxes of rhodamines doc
... proportional to the amount of rhodamine free in the cytosol. This observation allows the further determination of the concentration of drug free in the cytosol of resistantcells. The determination of karequires ... kaÁCið3Þ In this work, the rate of P-gp-associated efflux of rhodaminewas calculated at the steady-state, taking into account the following points: (a) the diffusion (in ux and efflux) of rhodamine ... cells and the parental cell line K562, in the absence of membranepotential, the gradient of rhodamine concentration gener-ated by the presence of the pump, the free intracellularrhodamine concentration,...
- 10
- 386
- 0
Báo cáo khoa học: Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction doc
... highlighting the role of b1 integrin in blood vessel morphogenesis. Indeed, conditionaldeletion of b1 integrin in endothelial cells inducesgeneral vascular defects, including reduced branchingand ... membrane binding proteins like talin, ezrin,radixin or moesin. FERM domains are composed of three subdomains, F1–F3, arranged in cloverleafshape. The F3 subdomain has a phosphotyrosine bind-ing ... (band 4.1 erzin radixin moesin) domain and three N-terminalNPXY ⁄ F motifs allowing either the folding of the protein on itself or its interaction with ICAP-1 and CCM2. ANK, ankyrin domain; MT, microtu-bules;...
- 13
- 381
- 0
Báo cáo y học: "Structural insights into the function of the core-circadian factor TIMING OF CAB2 EXPRESSION 1 (TOC1)" ppt
... through the RR domain [49]. Furthermore, animportant role of the RR domain in protein-protein inter-action was found for PRR3 when defined as a substrate of the kinase WNK1 [50,51]. In addition, ... primary amino-acidcomposition of these domains is unlike that of othermetal-binding domains, such as an EF-hand [59]. As the primary and secondary structures of the terminal domain of TOC1 did ... origin of func-tion for the amino-terminal module of TOC1. This furthersupports the phylogeny relations of the amino-terminalmodule of PRR to genuine RRs [40]. In each of the fourTOC1 modules,...
- 12
- 592
- 0
Báo cáo y học: "New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model" potx
... thanother endothelial cells in the body. In keeping with the theory of endothelial cell activation having a role in ANFH, coagulation-related gene expression in particularserine (or cysteine) ... and therefore predictors of disease initiation or progression are lacking. Two majorlimitations in the past have impeded the delineation of the pathophysiology: a lack of understanding of the inter-action ... of the sample including any pre-cipitate that may have formed was transferred into anRNeasy Mini Spin Column. The column was then pro-cessed according to the RNeasy Mini kit manufacturerinstruction....
- 12
- 312
- 0
Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDETrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Nghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXBT Tieng anh 6 UNIT 2chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015