... (CyH), and examined the impact of cycles of hypoxia ⁄ reoxygenation on the extent of acti-vation of known regulators of HIF-1a, namely phos-phoinositide-3 kinase (PI3K) ⁄ protein kinase B (Akt),extracellular ... the use of NOS inhibitors as single anti-tumor treatments. Moregenerally, by providing new insights into the regula-tion of HIF-1a in the context of tumor O2fluctua-tions, this study integrates ... Furthermore, thefailure of the NOS inhibitor to maintain the induction of HIF-1a in the presence of rotenone (Fig. 4D)strongly suggests that NO exerts these effects throughinhibition of the mitochondrial...