Báo cáo y học: "Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages" pdf
Báo cáo y học: "Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages" pdf
... equally conceived of the study, and partici-pated in the design of the study and performed immu-noassays, FACS analysis, statistical analysis, and wrote the first draft and final version of the ... CSM.CSM regulates phosphorylation of IRAK and degradation of IκB-α by MDMs and phosphorylation of IRAK in HEK cellsFigure 6CSM regulates phosphorylation of IRAK and degra-dation of IκB-α by MDMs and ... the presence of the reactive oxygen intermediate/species, cal-culated by dividing the mean channel fluorescence of atreated sample by that of the untreated one and multiply-ing by 100 to obtain the...
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Báo cáo y học: "Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs" pot
... struc-ture and tissue repair [1]. Cigarette smoke (CS)-inducedemphysema is characterized by enlargement of the air-spaces and a loss of alveolar structure [2,3] . Endothelialcell death and the regression ... recent study suggestedthat VEGFR2 is post-translationally modified by ROS/RNS present or derived by CS [30]. The pro-apoptotic Bad is the primary target o f Akt and Akt phosphorylates Bad and rendering ... VEGFR2 phosphorylation and downstreamsignaling leading to activation of eNOS, a key enzymelinked to endothelial survival and function. Therefore, the effect of CS on phosphorylated and total eNOS...
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Tài liệu Báo cáo khoa học: Oxygen tension regulates the expression of a group of procollagen hydroxylases docx
... expression of the procollagen hydroxylases. With the exception of PDI, whichis known to be induced by the UPR [41], however, none of the other enzymes was relevantly induced by the UPR,supporting the ... functional cluster of genes by the oxygen tension has already been found for the enzymesinvolved in the glycolytic cascade [29] and also for the keyplayers of angiogenesis [30].Considering the parallel ... [31]. Interestingly, the expressions of PHD-3[35,36] and eventually of PHD-2 itself are also oxygensensitive [35,36]. They are up-regulated by hypoxia by aprocess critically involving HIF,...
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Báo cáo y học: " Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNF-induced MEK/ERK signalling" ppsx
... of the study. AL was involved with the design and coordination of the study, drafting and editing of the manuscript.Acknowledgements The present study was supported by operating grants 14095 and ... immortalized chondrocytes is reduced by inhibition of MEK1/2 signalling [10]. TNF may thereforeregulate the expression of a subset of genes by alterations in the activity of these transcription factors ... coordinated production and degradation of the extracellular matrix. Type IIcollagen, aggrecan, and link protein – encoded by the genesCol2a1, Agc1 and Hapln1, respectively – are major compo-nents of the...
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Báo cáo y học: "Dendritic cells: In the forefront of immunopathogenesis and vaccine development – A review." doc
... component in the uptake and processing of luminal antigens. Such uptake may occur by endocytosis or by phagocytosis after passage of antigenthrough M cells. The DCs then present the processed ... identification of such DC subsets has led to a better understanding of their distribution and function in the body.In this review, several key properties of the immunobiology, immunopathogenesis and vaccinestrategies ... recognized by host T cells. TheseT cells may not be able to reject tumor cells. These mole-cules, then, are not immunogenic. In order to becomeimmunogenic they must be processed and presented by professional...
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Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx
... that oxygen acts as amolecular switch and alters the expression of the twonuclear genome coded isoforms of CytOX V [10,32]. The regulation of genes CytOX5a and CytOX5b, coding for the two isofoms ... characteristics of the enzyme following heme reduction. These studies suggestedthat heme might regulate not only the mammalian CytOXgene expression but also the catalytic activity of the enzyme by affecting ... contentCytOX was assayed in membrane fragments (SMP) by the method of Smith [20], wherein the rate of oxidation of ferrocytochrome cwas measured by following the decrease inabsorbency of its a band...
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Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" ppt
... their expression maylead to the alteration of both the formation and targeting of these complexes. Consequently, an oxidant-mediatedreduction in the protein expression of Mi-2α and mSin3a and ... com-plexes and thereafter their roles in disease.In summary cigarette smoke exposure reduced HDAC-2 activity and the expression of mSin3a and Mi-2α in the lungs of smoke exposed mice. This may contribute ... CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of HDAC2 by cigarette smoke and aldehydes. Arch Biochem Biophys 2010, 498:62-73.21....
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Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" pdf
... ourunderstanding of the roles of these co-repressor com-plexes and thereafter their roles in disease.In summary cigarette smoke exposure reduced HDAC-2 activity and the expression of mSin3a and ... (encoded by the Chd3 gene) and Mi-2β (encoded by the Chd4gene). Although the latter is predominantly associatedwith the NuRD complex they are structurally similar and no functional or cell type ... 2).Cigarette smoke exposure alters Mi-2α and Mi-2β expression. Consistent with the protein expression of mSin3a, the protein expression of Mi-2α was reduced by ~50% in the lungs of smoke- exposed...
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Báo cáo y học: "Inflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation" docx
... hypertrophy, inflammatory cells in the bronchoalveolar lavage fluid (BALF) and lung tissue and by determining the cytokine and chemokine profiles in the BALF of A/J mice exposed to cigarette smoke ... properly cited.elevated levels of T-lymphocytes, in particular CD8+cells, in lung parenchyma and airways [11-14]. Migra-tion and activation of inflammatory cells to the lung isregulated by the ... and interpretation of data and drafted the manuscript. FP-N helped on the draft of the manuscript. PAJ-H, AD-K and GF supervised the study and contributed to the writing of the final paper. All authors read and...
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngBáo cáo quy trình mua hàng CT CP Công Nghệ NPVMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếThơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXChuong 2 nhận dạng rui roTranh tụng tại phiên tòa hình sự sơ thẩm theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn xét xử của các Tòa án quân sự Quân khu (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015TÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ