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Báo cáo y học: "Improving benchmarking by using an explicit framework for the development of composite indicators: an example using pediatric quality of care" docx

Báo cáo y học:

Báo cáo y học: "Improving benchmarking by using an explicit framework for the development of composite indicators: an example using pediatric quality of care" docx

... 5 of 10METH O D O LOG Y Open AccessImproving benchmarking by using an explicit framework for the development of composite indicators: an example using pediatric quality of careJochen Profit1,2,3*, ... stability of results inuncertainty analysis provides an important quality check of the composite indicator as well as of the underlying framework and data [42].Step eight: links to other metricsIf ... developers may significantly influence per-formance ratings [14]. Therefore, development must be explicit and transparent.Theuniquecontributionandpurposeofthispaperisto advocate for using composite...
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báo cáo khoa học:

báo cáo khoa học: " Improving benchmarking by using an explicit framework for the development of composite indicators: an example using pediatric quality of care" potx

... Improving benchmarking by using an explicit framework for the development of composite indicators: an example using pediatric quality of care. Implementation Science 2010 5:13.Submit your next manuscript ... using an explicit framework for the development of composite indicators: an example using pediatric quality of careJochen Profit1,2,3*, Katri V Typpo4, Sylvia J Hysong2,3, LeChauncy D Woodard2,3, ... extremes of performance in order to enhance their usefulness andengender provider trust. Thus, stability of results inuncertainty analysis provides an important quality check of the composite...
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Báo cáo y học:

Báo cáo y học: "Improving survival by increasing lung edema clearance: is airspace delivery of dopamine a solution" pps

... extent, would be of significant interest. An important question highlighted by this research is why andhow does dopamine exert its effects in the lungs of animalmodels (and hopefully in patients)? ... weight/dry weight ratio (a gravimetricestimate of pulmonary edema) and improved survival in the dopamine-treated group. As such, the study providesinteresting and novel information. For example, the ... pulmonaryedema and hypoxemia [2]. The lung injury and edemaformation were proposed to be due to activation of intra-cellular signals that initiate/amplify an injurious cascade thatleads to systemic...
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Báo cáo y học:

Báo cáo y học: "Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action" pps

... degradation exceeds synthesis. The balance between synthesis and degradation is affected by age and is regulated by several factors produced by the synovium and chondrocytes, including cytokines, growthfactors, ... chondrocytes or the articular cartilage surface in OA [29,31]. The activity of many MMPs increases in OA by either an increase in theirown synthesis, an increased activation by their proen-zymes, ... matrix synthesis [29,41]. The production of NO, another inflammatory mediator syn-thesized by the cartilage in OA and well documented inexperimental OA, is stimulated by the proinflammatorycytokines...
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Báo cáo y học: "P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis" ppsx

... contributionsKKB, SAH and EBH performed all of the in vivo studiesand analyzed the data. LH performed all the in vitro stud-ies and analyzed the data. MB designed and prepared the formulations for the p38 ... http://www.journal-inflammation.com/content/5/1/22Page 6 of 8(page number not for citation purposes)contributes to the development and maintenance of neu-ropathic pain by inducing the synthesis of inflammatorycytokines and other neuroactive ... The structures of the synthe-sized compounds were verified by nuclear magnetic reso-nance, mass spectroscopy and elemental analysis. The purity of the compounds was > 99% as determined by high...
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báo cáo hóa học:

báo cáo hóa học: " TLR3 signaling is either protective or pathogenic for the development of Theiler''''s virus-induced demyelinating disease depending on the time of viral infection" docx

... including synthetic dsRNA poly IC, are recognized not only by TLR3 but also by MDA5 and PKR [16, 24]. Therefore, the relative role of TLR3-mediated signaling in the development of TMEV-induced demyelinating ... [26, 45]. Therefore, the presence of a certain level of type I IFN signaling during early TMEV infection appears to be necessary for survival of the animals. The high level of type I IFN production ... in the CNS of NLM and TLR3KO-SJL at 7 and 21 dpi were analyzed by quantitative PCR. Data are expressed by fold induction after normalization to the GAPDH mRNA levels. The values given are means...
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Báo cáo Y học: Agmatine oxidation by copper amine oxidase Biosynthesis and biochemical characterization of N-amidino-2-hydroxypyrrolidine pdf

Báo cáo Y học: Agmatine oxidation by copper amine oxidase Biosynthesis and biochemical characterization of N-amidino-2-hydroxypyrrolidine pdf

... mplexes. I n human NOS-II (top panel), N-amidino-2-hydroxypyrrolidine is hosted in the hydrophobic cavitydefined by the heme p rosthetic group and by the facinghydrophobic residues Ala270 and Val271, ... conversion of L-arginine toL-citrulline (at pH 7.5and 37.0 °C) and of the trypsin catalyzed hydrolysis of N-a-benzoyl-L-arginine p-nitroanilide (at pH 6.8 and21.0 °C) by N-amidino-2-hydroxypyrrolidine ... ·10)1Mphosphate buffer) and 25.0 °C (Fig. 1). Values of kcatand K0mare independent of the enzyme assay.Biosynthesis of N-amidino-2-hydroxypyrrolidineN-Amidino-2-hydroxypyrrolidine was synthesized as...
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Báo cáo y học:

Báo cáo y học: " Myoglobin clearance by super high-flux hemofiltration in a case of severe rhabdomyolysis: a case report" doc

... clear-ances of approximately 4.3 g [18,19]. The SC using a Gambropolyflux 11S membrane was only 37%, however, and neither of these studies reported on myoglobin clearance or the cutoffsize of the ... clearance of myoglobin than conventionalhemofiltration, and it may provide a potential modality for the treatment of myoglobinuric acute renalfailure.IntroductionRhabdomyolysis and myoglobinuria ... M, Wolfgang J: Continuous veno-venous hemofiltration for the immediate management of mas-sive rhabdomyolysis after fulminant malignant hyperthermiain a body builder. Anesthesiology 2001, 94:1139-1141.Open...
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Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"

... from all the subjects. This study protocol was approved by the Ethics Committee of the Nagoya University Graduate School of Medicine. Tests for Helicobacer pylori (H. pylori) antibody and pepsinogens ... atrophy. The ORs of the G/A and A/A for gastric cancer was 1.05 (95% CI 0.63-1.74) and 1.05 (95% CI 0.27-4.07), respectively. Table 4 The Gab1 genotype frequency and ORs for gastric cancer ... part by a Grant-in-Aid for Scientific Research on Special Priority Areas of Cancer from the Ministry of Education, Culture, Sports, Science and Technology of Japan. Conflicts of interest The...
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Tài liệu Báo cáo Y học: Bivalent cations and amino-acid composition contribute to the thermostability of Bacillus licheniformis xylose isomerase doc

Tài liệu Báo cáo Y học: Bivalent cations and amino-acid composition contribute to the thermostability of Bacillus licheniformis xylose isomerase doc

... glucose than for xylose,and the relative effectiveness of the three metals was the same. Occupancy rate of the M2 site necessary for activityon glucose may be higher than that for activity on xylose; ... responsible for the thermostability of Thermus thermophilus isopropylmalate dehydrogenase. Biochim.Biophys. Acta 1545, 174 –183.5. Petsko, G.A. (2001) Structural basis of thermostability inhyperthermophilic ... in the rest of the study.Purification of the recombinant protein and physicalproperties The B. licheniformis xylA gene was expressed from its ownpromoter in plasmid pBL2. The recombinant enzyme...
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