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báo cáo khoa học: "Subcuticular microstructure of the hornet''''''''s gaster: Its possible function in thermoregulation" pptx

báo cáo khoa học:

báo cáo khoa học: "Subcuticular microstructure of the hornet''''s gaster: Its possible function in thermoregulation" pptx

... point out that in hornets the abdomen is called agaster, because the first segment of the abdomen conjoinsduring the pupal stage with the three segments of the tho-rax and it is the remaining ... image of the tissue. The magnetic spins areexcited in slices of finite width, and for each slice, a singleimage is obtained. The relative intensity of each element of the imagedepends on the ... isonly the terminal part of the gaster, comprising 1/4-1/3 of the total gastral length and less so of the total volume,which contains most of the small and large intestine, the genitalia (degenerated...
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Tài liệu Báo cáo khoa học: Functional dissection of the Schizosaccharomyces pombe Holliday junction resolvase Ydc2: in vivo role in mitochondrial DNA maintenance pptx

Tài liệu Báo cáo khoa học: Functional dissection of the Schizosaccharomyces pombe Holliday junction resolvase Ydc2: in vivo role in mitochondrial DNA maintenance pptx

... [14,20]. Binding of CCE1 results in the complete unpairing of the four base-pairs in the centre of the junctions with a lesser disruption of the next base-pairs[19], which is reminiscent of the structure ... base-pairs in the centre of the junctions [19]. Detailedunderstanding of the functional role of these interactionswould require the crystal structure of the Ydc2–junctioncomplex. In this study the function ... important functional role, such as the correctpositioning of the SAP motifs in relation to the rest of the protein as well as for the stability of the protein. The truncated Ydc2 mutant proteins localizeto...
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Báo cáo khoa học: Molecular basis of the unusual catalytic preference for GDP/GTP in Entamoeba histolytica 3-phosphoglycerate kinase doc

Báo cáo khoa học: Molecular basis of the unusual catalytic preference for GDP/GTP in Entamoeba histolytica 3-phosphoglycerate kinase doc

... structures of the wild-type, single- and double-mutant EhPGKs in aclosed conformation will certainly help to clarify the molecular arrangement in the guanine ring binding siteduring the binding of ... and Val341 (patch C). The corresponding reported amino acid residuesinvolved in adenine binding in the other crystallizedproteins, as well as in the EhPGK identified in the predicted model, were ... were constructed, differing only in the particular combination of side-chain conformers, being each of them optimized by energy minimization in the presence of GDP with the CHARMM27 force field...
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Báo cáo khoa học: CpG methylation of the CENP-B box reduces human CENP-B binding pptx

Báo cáo khoa học: CpG methylation of the CENP-B box reduces human CENP-B binding pptx

... and the N7 atom of guanine 16 by the CpGmethylation may be a reason for the reduced specificity of CENP-B to the CENP-B box sequence.What is the functional meaning of the CpG methyla-tion of the ... coloured red in the modelstructure. The CpG sites that are sharply kinked by the CENP-B binding are encircled in red. The nucleotide sequences of sites 1 and 3 areindicated in the left column. ... modelled on the C5 atoms of cytosines in the CpG dinucleotides, are coloured red. The van der Waals radii of the methyl groups (2.0 A˚) are shown in orange circles. The van der Waalsradii of the Thr44...
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Báo cáo khoa học: Crystal structure of the halotolerant c-glutamyltranspeptidase from Bacillus subtilis in complex with glutamate reveals a unique architecture of the solvent-exposed catalytic pocket docx

Báo cáo khoa học: Crystal structure of the halotolerant c-glutamyltranspeptidase from Bacillus subtilis in complex with glutamate reveals a unique architecture of the solvent-exposed catalytic pocket docx

... present in most other GGTs at the C-terminal region of the L-subunit. In E. coli GGT, upon autocatalytic cleavage of the peptide bond on the N-terminal side of Thr391, the C-terminal segment of the ... ª 2010 The Authors Journal compilation ª 2010 FEBSligand binding to the enzyme (Fig. 4); there is littlecorrespondence in the amino acids that are involved in the recognition of the functional ... [8–10]. The side chain of Thr391 of the E. coli GGT precursor protein acts as the nucleophile for the cleavage, by which it becomes the new N-terminal residue of the S-subunit, and in turn acts as the...
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Báo cáo khoa học:

Báo cáo khoa học: " An assessment of the RIFLE criteria for acute renal failure in critically ill HIV-infected patients" docx

... creatinine above the baseline serum creatinine level. When the baseline serum creatinine is unknown and there is no past history of chronic kidney disease, serum creatinine is calculated using the ... sought to evaluate retrospectively the ability of the RIFLE criteria (Table 1) to predict outcome of the HIV-infected patients admitted to the Infectious Diseases ICU of our Hospital (Hospital de Santa ... race, type of HIV, stage of HIV infection, highly active antiretroviral therapy (HAART),comorbidity, and severity of illness. In all cases, maximumRIFLE occurred within the first week of hospitalization.LetterAn...
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Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf

Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf

... difference in number of ion pairswould be reflected in a corresponding difference in the stability of the proteins in organic solvents. Indeed,although the stabilities of the two SODs were indistin-guishable ... excluded all residuesinvolved in the binding of the metal cofactor.ApeSODs in different forms were superimposed with the least square fit of Ca atoms of the residues in the range10–200. ApeSOD ... metal-binding siteat the interface of the two domains, which consists of four side chains: two (His31 and His79) from the N-terminal domain and two (Asp165 and His169) from the C-terminal domain...
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Tài liệu Báo cáo khoa học: Homologous expression of the nrdF gene of Corynebacterium ammoniagenes strain ATCC 6872 generates a manganese-metallocofactor (R2F) and a stable tyrosyl radical (Y•) involved in ribonucleotide reduction ppt

Tài liệu Báo cáo khoa học: Homologous expression of the nrdF gene of Corynebacterium ammoniagenes strain ATCC 6872 generates a manganese-metallocofactor (R2F) and a stable tyrosyl radical (Y•) involved in ribonucleotide reduction ppt

... [35] may not be considered in the light of the results obtained in the present study. Rather, the involvement of manganese in the in vivo assembly of the metallocofactor of C. ammoniagenes R2F is ... RNR and that of other class 1RNRs or, instead, is a result of the interaction of the R2F with the inactivated (oxidized) form of the R1E.We consider the first option unlikely. Under these cir-cumstances, ... samples. The rad-ical concentration was calculated by determining the area of the radical signal in the absorption spectrum by cubicspline interpolation [52] in the range 403–413 nm using the coefficient...
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Tài liệu Báo cáo khoa học: Crystal structures of the regulatory subunit of Thr-sensitive aspartate kinase fromThermus thermophilus pdf

Tài liệu Báo cáo khoa học: Crystal structures of the regulatory subunit of Thr-sensitive aspartate kinase fromThermus thermophilus pdf

... insertedinto the ACT2 domain; and (c) two ACT domains,each from a different chain, interact to form an effec-tor-binding unit. The effector-binding unit of the ACT domain in the b-subunit of CgAK ... A chain, and residues in green are in the B chain. (C) Vacant Thr-binding site in TtAKb-free. Residues in blue are in the E chain, and residues in orange are in the F chain. (D) Structure-based ... CgAK[20]. In these ACT domains of AK proteins, thereare common structural features: (a) two ACTdomains are arranged in the C-terminal portion of asingle polypeptide; (b) the ACT1 domain is insertedinto...
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Tài liệu Báo cáo khoa học: Limited suppression of the interferon-b production by hepatitis C virus serine protease in cultured human hepatocytes pptx

Tài liệu Báo cáo khoa học: Limited suppression of the interferon-b production by hepatitis C virus serine protease in cultured human hepatocytes pptx

... serine prote-ase located in the amino-terminal domain of NS3. Ser-ine protease activity of NS3 requires NS4A, a proteinconsisting of 54 amino acid residues, to form a stablecomplex with the ... factors, including IFN regulatory fac-tor-3 (IRF-3) and kinases, including the Tank-bindingkinase 1 (TBK-1) and inhibitor of j B kinase e (IKK-e)[28–31]. Although IRF-3 is located in the cytoplasm ... [8–10].Virus-infected cells trigger the innate immuneresponse by recognizing viral components, includingDNA, ssRNA, dsRNA and glycoproteins. Thisresponse initiates signaling pathways leading to the induction...
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