báo cáo khoa học: "Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia" doc

... between the BCL11B gene and the other four genes of interest in the healthy controls.DiscussionIncreasing numbers of translocations involving the BCL11B locus [8,10,11] or high levels of BCL11B ... 3:44http://www.jhoonline.org/content/3/1/44Page 2 of 7RESEARC H Open AccessAnalysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemiaXin Huang1,2, Shaohua ... known about the expression pattern of these genes in T-ALL. Thus, analyzing the expression pattern of these genes in malign ant T-cells is important because BCL11B disruption and disturbed expression...

Báo cáo khoa học: "Treatment results for hypopharyngeal cancer by different treatment strategies and its secondary primary- an experience in Taiwan" pptx

... occurs in Taiwaneseman, and the incidence of oral cavity cancer and eso-phageal cancer is increasing 13.1% and 4.1% respectively in ten years in Taiwan[32]. On the other hand, most of our patients ... many patie nts in the former group. On the other hand, a meta-analysis[13] of six trials comparing induction chemotherapy and radiotherapy with alternating or concomitant chemo-radiotherapy (CCRT) ... can-cers. The results of these prospective trials wereencouraging; they indicated that the larynx could b epreserved using combined chemotherapy and radiother -apy without compromising overall...

báo cáo khoa học: " Epiglottis reshaping using CO2 laser: a minimally invasive technique and its potent applications" doc

... [2]. The term LRM wasfirst used by Jackson and Jackson in 1942 to designate stri-dor caused by the indrawing of the supraglottis with inward curling of both sides of the epiglottis, or by the backward ... distress, and death [2]. Many of them are attributed to the exces-sive removal of laryngeal tissue [2]. In cases of LRM and OSAS where the main etiologic factoris the inward curling or the backward ... cartilage-reshaping technique,which provides accuracy in obtaining the desired shape of the irradiated cartilage while minimizing adjacent tissuedamage in the same time. Following the laser applicationthe...

Báo cáo toán học: "MAINTENANCE HORMONAL TREATMENT IMPROVES PROGRESSION FREE SURVIVAL AFTER A FIRST LINE CHEMOTHERAPY IN PATIENTS WITH METASTATIC BREAST CANCER" docx

... after the first line of chemotherapy in patients with positive tumour hormone receptor status. The patients with early disease progression during first-line chemotherapy were not included. In ... (single versus multiple); type of first-line chemotherapy (anthracycline- and/ or taxane-containing regimen versus other); previous line of hormonotherapy administered in metastatic setting ... the impact of hormonal treatment given as maintenance therapy was analysed. Statistical analysis The duration of PFS is defined as the time from the beginning of first line chemotherapy treatment...

Tài liệu Báo cáo khoa học: Analysis of the molecular dynamics of medaka nuage proteins by ﬂuorescence correlation spectroscopy and ﬂuorescence recovery after photobleaching doc

... eggs in the one-cell stage to visualize the localization and to mea-sure the mobility of the components in the PGCs. The medaka embryo was peeled off the chorion, and the segment containing the ... diagram of the constructs microinjected into the medaka eggs and transfected into HeLa cells. The olvas, nanos and tudorcoding sequences were joined to the C-terminal region of the GFP or RFP coding ... movement in the granules and diffused in the cytosol of HeLa cells, just as in the medaka embryo. The other two gene products, Nanos and Tudor of the medaka, which are known as con-stituents of the...

Tài liệu Báo cáo khoa học: Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant ppt

... Note the presence of the granules in the cyto-plasm of the cells. Bar, 20 lm. (D) The percentage of EGFP-containing cells displaying granules is shown. The average percentages,including standard ... [8]. In human and HD transgenic mice, the disease corre-lates with the appearance of intraneuronal, intranu-clear and perinuclear aggregates ⁄ inclusions containing the abnormal N-terminal htt fragment ... polyglutamine proteins intoamyloid-like ﬁbrils [39] and are associated with aggre-gates in the brains of HD transgenic mice [40]. Hsp70 and Hdj-1 can inhibit polyQ aggregation and reduce the size of...

Báo cáo khoa học: Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast ppt

... compared with those with the C-terminal domain deleted is consistent with this (Figs 4 and 5). Hybrid proteins carrying the N-terminus of one protein and the Sm domain of the other localize according ... the latter, indicating that in the absence of an N-terminaldomain distinct localization is lacking. Finally, the Lsm1p Sm domain by itself (LsmDN1DCp) accumu-lates in both the nucleus and the cytoplasmic ... of mutant and hybrid Lsm1 and Lsm8 proteins, shedding light on the relative importance of their various domains in determining their localization and ability tosupport growth. Although no single...

Báo cáo khoa học: Analysis of the NADH-dependent retinaldehyde reductase activity of amphioxus retinol dehydrogenase enzymes enhances our understanding of the evolution of the retinol dehydrogenase family pot

... dashes. The active site (YTVAK) and the cofactor-binding motifs aremarked in bold. The D43, T67 and A69 residues, involved in cofactor specificity, are indicated by asterisks. Flanking the N-terminal ... at the N-terminus with the hemagglutinin (HA) epitope wereproduced in COS-7 cells and purified in the microsom-al fraction. The enzymatic activity of this fraction wasassayed against retinoids. ... activity[12]. The specific activity of each amphioxus enzymewas 0.25 nmol of retinolÆmin)1Æ(mg of microsomes))1for RDH1 incubated with 15 lm all-trans-retinal, and 1.4 nmol of retinolÆmin)1Æ(mg of...

Báo cáo khoa học: Stage speciﬁc expression of poly(malic acid)-afﬁliated genes in the life cycle of Physarum polycephalum Spherulin 3b and polymalatase potx

... bc-crystallin fold. The residues shown in grey indicate the side chains and backbone sites thatare involved in calcium binding [24]. The residues in the conserved tyrosine corners are in bold [24]. ... could be the result of loss of induction at the transcriptional level, of loss of activation of the synthetase protein itself, or of derepression of enzyme(s) catalysing PMLA degradation. An interest-ing ... function.bc-Crystallins are two-domain proteins found in vertebrate eye lenses and have distant relatives in microorganisms (e.g. the proteins in Fig. 2). The bc-crystallin domain of spherulin 3a from...

Báo cáo khoa học: "Analysis and Synthesis of the Distribution of Consonants over Languages: A Complex Network Approach" pptx

... itself with one of the nodes in the set VCit does so with the one having the highest degree (=3) rather than with others in order to achieve preferential attachmentwhich is the working principle ... as synthe-sis of the distribution of the consonants across the languages. In the current work, with the help of PlaNet weprovide a systematic study of certain interestingfeatures of the consonant ... these 21 consonants.On the other hand Regime 2 of Figure 3(a) as wellas Regime 1 of Figure 3(b) comprises of the rest of the consonants. The point marked as x in both the ﬁgures indicates the...

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