báo cáo khoa học: "The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1" docx

báo cáo khoa học: "The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1" docx

báo cáo khoa học: "The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1" docx

... Open Access The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP9 0A and HSP90B1 Saad Z Usmani 1* , Robert D Bona 2 , Gabriela Chiosis 3 , Zihai ... cytosolic HSP90 (HSP90AA1), the ER paralogue gp96 (HSP90B1) and the mitochondrial member TRAP1 (HSP90L). We evaluated the in vitro anti-tumor activity an...
Ngày tải lên : 10/08/2014, 22:21
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Tài liệu Báo cáo khoa học: The phosphatase activity of the isolated H4-H5 loop of Na+/K+ ATPase resides outside its ATP binding site docx

Tài liệu Báo cáo khoa học: The phosphatase activity of the isolated H4-H5 loop of Na+/K+ ATPase resides outside its ATP binding site docx

... protein and its truncation products. K + activated p-nitrophenyl- phosphatase as a partial activity of Na + /K + ATPase was measured as described previously [17]. S tatistical analysis of the comparison ... plasma membranes of mammalian cells. The enzyme is a heterodimer of a 100 kDa catalytic subunit and a heavily glycosylated b subunit of about 55 kDa [1–3]. Ouabai...
Ngày tải lên : 19/02/2014, 16:20
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Báo cáo khoa học: The antibiotic activity of cationic linear amphipathic peptides: lessons from the action of leucine/lysine copolymers on bacteria of the class Mollicutes doc

Báo cáo khoa học: The antibiotic activity of cationic linear amphipathic peptides: lessons from the action of leucine/lysine copolymers on bacteria of the class Mollicutes doc

... also for the antimicrobial activity of these peptides. In this work, we have taken advantage of the fact that bacteria of the class Mollicutes are devoid of an outer membrane and of a cell wall, ... of membrane depolarization and the delay necessary to reach a steady- state level of depolarization. Actually, 0.1 l M melittin totally depolarized the A. laidlawii membra...
Ngày tải lên : 23/03/2014, 17:21
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Báo cáo khoa học: The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2 pot

Báo cáo khoa học: The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2 pot

... this interaction has an effect on the enzyme activity of the kinase. In this study, we demonstrate that both kinases (SRPK 1a and SRPK1) interact with both scaffold attachment factors (SAFB1 and ... protein-specific kinase involved in mediat- ing the interaction and localization of pre-mRNA splic- ing factors in mammalian cells. J Cell Biol 140, 737–750. 9 Nakagawa O, Arnold...
Ngày tải lên : 30/03/2014, 01:20
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Báo cáo khoa học: Metal exchange in metallothioneins – a novel structurally significant Cd5 species in the alpha domain of human metallothionein 1a ppt

Báo cáo khoa học: Metal exchange in metallothioneins – a novel structurally significant Cd5 species in the alpha domain of human metallothionein 1a ppt

... divided by a factor of 33. UV spectra were acquired using a Cary 5G UV-Vis-NIR spectrophotometer (Varian Canada, Mississauga, Canada) in a 1 cm quartz cuvette at room temperature (22 °C) and recorded ... ESI-TOF mass spectrometer (Waters Micromass, Mississauga, Canada) at room temperature (22 °C), and recorded using the mass lynx software package version 4.0. The ESI-TOF spectrome...
Ngày tải lên : 16/03/2014, 06:20
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báo cáo khoa học: " The YlmG protein has a conserved function related to the distribution of nucleoids in chloroplasts and cyanobacteria" pdf

báo cáo khoa học: " The YlmG protein has a conserved function related to the distribution of nucleoids in chloroplasts and cyanobacteria" pdf

... 5'-CACCGAGAAGTCAA- CAGCTCGGTCATCGAC-3' and 5'-TCAAGTCTTC- CAATTTCTACCCAGTGCTGC-3' for AtYLMG1-1, 5'- CCTCAACATATATAACACCATC-3' and 5'-GACAG- GTTCAGGTCATAGAAG-3' ... 5'-GACAG- GTTCAGGTCATAGAAG-3' for At5g21920, 5'-TATCT- GAACACTCCGTTGACGGTA-3' and 5'-CAAAGATA AACGGAATACGATC-3' for At4g27990, 5'-GCAATGG- GAAGCAGTGG...
Ngày tải lên : 12/08/2014, 03:21
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Tài liệu Báo cáo khoa học: The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression ppt

Tài liệu Báo cáo khoa học: The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression ppt

... inter- actions are mediated through many salt bridges and van der Waals contacts between a 2 and b 4 of RRM 1 and b 2 and a 1 of RRM 2, respectively (Fig. 6D). Another interesting example of RRM–RRM ... of another protein that acts as a cofactor. Both U2B¢ and CBP20 need a cofactor, U 2A and CBP80, respectively, to recognize RNA. Ternary structures of these com...
Ngày tải lên : 19/02/2014, 17:20
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Báo cáo khoa học: The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba docx

Báo cáo khoa học: The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba docx

... fractions was measured and the purity of pyridoxal kinase was determined by SDS ⁄ PAGE [29] and MALDI-TOF-MS (see Supplementary material). General analytical methods Enzymatic formation of vitamin ... unphosphorylated dietary precursors catalysed by PKH is required ubiquitously in mammalian tissues [15]. Decreased activity of PKH leads inter alia to a decreased availability o...
Ngày tải lên : 07/03/2014, 10:20
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Báo cáo khoa học: The multi-replication protein A (RPA) system – a new perspective ppt

Báo cáo khoa học: The multi-replication protein A (RPA) system – a new perspective ppt

... exclusively of archaeal RadA protein, a homolog of bacterial RecA, eukaryotic Rad51 and archaeal RadB. This protein is involved in DNA repair and recombination [42,188] PCNA PCNA, or cyclin, is a non-histone ... Dmc1 enhances DNA topoisomerase II catenation activity independent of sequence homology. Chromosoma 117, 297–302. 163 Koshiyama A, Hamada FN, Namekawa SH, Iwabata...
Ngày tải lên : 23/03/2014, 06:20
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Báo cáo khoa học: "The mating system in a Scots pine clonal seed orchard in Poland" pdf

Báo cáo khoa học: "The mating system in a Scots pine clonal seed orchard in Poland" pdf

... (Shaw and Allard, 198 2a) and natural populations (Neale and Adams, 1985). Apart from the theoretical value of such studies they are also of prac- tical interest, especially ... natural populations (Neale and Adams, 1985; El-Kassaby et al, 1987; Muona and Harju, 1989) and has been explained mainly by the family struc- ture of a stand. I...
Ngày tải lên : 08/08/2014, 23:22
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