báo cáo khoa học: "Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy" ppsx

... prevent the development of resistance tothese agents. The results of ongoing clinical trials with mTOR inhibitors, as single agents and in combination,will better define their activity in cancer. Competing ... of mTOR, in particular, thePI3K/Akt /mTOR pathway. mTOR signaling is critical in the development of manytumors, including renal cell carcinoma (RCC), in which mTOR can play a specific role in ... majorlink in tumorigenesis. Preclinical data have supported thepivotal role of mTOR in cancer and led to the develop-ment of mTOR inhibitors as a therapeutic target [13].The Development of mTOR...

Báo cáo khoa học: " Humus form development and succession of dwarf shrub vegetation in grass dominated primary Pinus sylvestris forests" ppt

... Empetrumnigrum and Vaccinium myrtillus), D flexuosa and forest mosses. The declining vigour of D flexu-osa has been established from decreasing flow-ering intensity and increasing ... to maintain dominance in theherb layer for a long period of time during succession in pine forests. 3) Facilitation in the succession of the undergrowth of the pine forests ... and elementalcomposition of the organic matter and of waterextracts. Details about sampling and analyticalprocedures are given by Emmer and Sevink(1994), and Emmer and...

Tài liệu Báo cáo khoa học: "Beefmoves: Dissemination, Diversity, and Dynamics of English Borrowings in a German" ppt

... frequency in Covoduring year t and frequency change in MZEE between t and year u = t + iInitial frequency and dissemination in MZEE In studying the fate of all words in two En-glish Usenet corpora, ... detection of Englishinclusions in mixed-lingual data with an applicationto parsing. Ph.D. thesis, Institute for Communicat-ing and Collaborative Systems, School of Informatics,University of Edinburgh.Eduardo ... portion of the MZEE cor-pus, the training data consisted of the disjoint sub-sets of the English and German CELEX wordlists(Baayen et al., 1995), as well as the words used in Covo (to obtain coverage...

báo cáo khoa học: " A pilot histomorphology and hemodynamic of vasculogenic mimicry in gallbladder carcinomas in vivo and in vitro" pptx

... EGFreceptor. Laminin 5 is the only laminin that containsthe g2 chain, which following cleavage into promigratoryfragments , the domain Ⅲ region, causes increased levels of matrix metalloproteinase-2 ... significance. In this study, we further studied histomorphology and hemodynamic of VM in gallbladder carcinomas in vivo and in vitro.Methods: The invasive potential of human gallbladder carcinoma cell lines ... commonmalignant tumor of the digestive tract and the leadingcause of cancer- related deaths in China and in Shang-hai [26]. 5-year survival for the patients lies between0% and 10% in most reported...

Báo cáo khoa học: "Cerebral perfusion pressure and risk of brain hypoxia in severe head injury: a prospective observational study" ppt

... remained stable in order to identify and correct causes of non-ischemic hypoxia[18]. The principal causes of low-extractivity hypoxia, such asanemia and hypoxemia, and the causes of high-affinity ... according tothe Glasgow Outcome Scale (GOS).Continuous monitoring and sampling of multimodal physiological dataIntracranial pressure (ICP) and PtiO2 were continuously moni-tored using an intraparenchymal ... CPP and PtiO2, with apeak of PtiO2 at a CPP value around 78 mmHg [15].The importance of CPP for maintaining an adequate level of tissue oxygenation is a point of clinical relevance. Taking...

Báo cáo sinh học: " Demographic characterization, inbreeding and maintenance of genetic diversity in the endangered " ppsx

... the so-called genetic conservation index and minimize the inbreedingcoefficient of the hypothetical offspring of the couple. © Inra/Elsevier, Parisdonkey / endangered ... with a male offspring and each female with a female offspring tothe next generation, 2) standardize the family size minimizing the variance (o, k 2), and 3) increase the ... wouldcalculate the effective number of founders and the inbreeding coefficient of thehypothetical offspring of each possible populating couple. In this way, those coupleswhich...

Tài liệu Báo cáo khoa học: Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIa pdf

... forTF binding and ⁄ or the cofactor effect [13]. In terms of intramolecular propagation of the TF-induced signal,the most interesting mutations are those that onlyaffect activity of the FVIIaÆTF ... complex.The amino acid residues that determine the zymo-genicity of free FVIIa are as interesting as thoseinvolved in the TF-induced allostery. Amino acid resi-dues in FVIIa that are involved in the ... allowsvisualization of the modiﬁcation using SDS–PAGE.The rate of carbamylation of the N-terminal aminogroup [Ile153(16)] of the protease domain in G372A-Fig. 2. PABA inhibition of G372A-FVIIa and FVIIa...

Tài liệu Báo cáo khoa học: Substrate speciﬁcity and inhibition of brassinin hydrolases, detoxifying enzymes from the plant pathogens Leptosphaeria maculans and Alternaria brassicicola ppt

... phytoalexins brassicanal A, erucalexin, rutalex- in, brassilexin, camalexin (chemical structures in Fig. S2) and cyclobrassinin [7]. Interestingly, onlycyclobrassinin (Fig. 8A) exhibited an inhibitory ... phyto-alexin that displayed an inhibitory effect was furtherexamined in order to determine the type of inhibition and the Kiusing brassinin (0.10–0.40 mm) as a sub-strate in the presence of inhibitor ... Brassinin saturationcurve for BHLmL2 and (B) brassinin saturation curve for BHAb. Themixture was incubated at 23 °C for 45 min in the presence of increasing concentrations of brassinin (0–1...

Tài liệu Báo cáo khoa học: Identiﬁcation, sequencing, and localization of a new carbonic anhydrase transcript from the hydrothermal vent tubeworm Riftia pachyptila docx

... in the alignment,Fig. 3) combined with a histidine cluster consisting of residues H3, H4, H10, H15 and H17, explains the gen-eral high efﬁciency of CAII isoforms as a catalyst[27,29] because ... posi-tions 94, 96 and 119 in CAII from Homo sapiens)which are directly involved in binding the zinc cofac-tor, are conserved in the two R. pachyptila sequences(positions labeled ‘Z’ in Fig. 3). ... a hydrophobic amino acid (leucine)instead of the histidine that is shared by almost allother sequences. The same amino acid replacementoccurs in the two isoforms CAa and CAb of Droso-phila...

Tài liệu Báo cáo khoa học: ATP-dependent modulation and autophosphorylation of rapeseed 2-Cys peroxiredoxin docx

... informationabout the polarity of local environments surroundingeither extrinsic probes that bind to proteins or intrinsicfluorophores buried in the protein interior. In a firstset of experiments, we relied ... oligomerization of 2-Cys Prx wereconsistent with a specific binding of ATP ⁄ Mg to theprotein. In line with this prediction, positive and nega-tive differences in absorbance appeared following incu-bation ... the emis-sion intensity with a concurrent displacement of theACBFig. 2. Effect of the binding of ATP ⁄ Mg2+to 2-Cys Prx on the fluo-rescence emission of extrinsic and intrinsic chromophores....

Xem thêm