... yielded good performance. We chose a bandwidth of30 for IP reads and a bandwidth of 300 for control reads. For enriched region i, we obtain four density functions,, , , , for the forward and reverse ... problem for each i by startingwith Ni = 1 and solving the minimization over ai and mi byrandom-restart gradient descent (see, for example, [33]).We then increment Ni and solve over ai and ... amotif closely resembling that previously identified byPark and co-workers [16]. Notably, four binding sitesoccur in two closely spaced pairs, and three occur in aclosely spaced triplet, and it...