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Báo cáo y học: "De novo acute megakaryoblastic leukemia with p210 BCR/ABL and t(1;16) translocation but not t(9;22) Ph chromosome" pdf

Báo cáo y học:

Báo cáo y học: "De novo acute megakaryoblastic leukemia with p210 BCR/ABL and t(1;16) translocation but not t(9;22) Ph chromosome" pdf

... report of de novo AMKL with p210 BCR/ABL and der(16 )t(1;16)( q21;q23) translocation but not t(9;22) Ph chromosome. [Key words] Imatinib, Acute megakaryocytic leukemia, p210 BCR/ABL 9 suggested ... 24 × 109/L, with 54% megakaryoblasts, 17% promegakaryocytes, 10% myelocytes, 8% band forms, 7% neutrophils, 3% lymphocytes, and 1% monocytes. Plasma D-dimer and lactate dehydrogenase (LDH) ... Acute megakaryoblastic leukemia (AMKL) is a type of acute myeloid leukemia (AML), in which majority of the blasts are megakaryoblastic. De novo AMKL in adulthood is rare, and carries very...
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Báo cáo y học: " De novo genome sequence assembly of a filamentous fungus using Sanger, 454 and Illumina sequence data" ppsx

... by DP. Assemblies were performed by SD,NYL, MS, SKC and DP. Data analysis was performed by SD,SKC, TRD and NYL under the direction of IB. The manuscriptwas prepared by SD, CB, JB and SJMJ with ... they generateshort (typically 450 bp for 454; 50 to 100 bp for Illumina and SOLiD) reads that cannot resolve low complexity sequenceregions or distributed repetitive elements; they have system-specific ... properly cited.De novo sequence assembly<p>A method for de novo assembly of a eukaryotic genome using Illumina, 454 and Sanger generated sequence data</p>AbstractSequencing-by-synthesis...
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Báo cáo y học: "Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis" ppsx

... adenomas and carcinomas. Cochrane Database Syst Rev 2004, 2:CD004079.8. Cryer B, Feldman M: Cyclooxygenase-1 and cyclooxygenase-2selectivity of widely used nonsteroidal anti-inflammatorydrugs. ... defining effi-cacy and assigning causality, but their external validity orgeneralizability can often be low [34] and they are rarely suffi-ciently large or long running to identify all adverse events[35,36]. ... for hypertension, hyperlipidemia, diabetes, ischemic heart disease, BMI, kidney disease, RA, and aspirin useAMI, acute myocardial infarction; BMI, body mass index; CABG, coronary artery bypass...
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Báo cáo Y học:Association of the thyrotropin receptor with calnexin, calreticulin and BiP Effects on the maturation of the receptor docx

Báo cáo Y học:Association of the thyrotropin receptor with calnexin, calreticulin and BiP Effects on the maturation of the receptor docx

... Cys-free DMEM supplemented with 10%dialyzed fetal bovine serum, 10 mMsodium butyrate, with or without 100 lMMG132 and with or without 1 mMcastanospermine (CST). They were then pulsed for 1 ... supple-mented or not with MG132. Samples were analyzed by SDS/PAGEafter a reduction step (A, B) and quantified by performing phos-phorimaging (C, D). (C) TSHR bearing high mannose and complex-type structures; ... type N-glycans (Fig. 5A and B). These results show that interactions with CNX and/ or CRT prevent the TSHR from being rapidlydegraded just after its synthesis. However it does not seem likely...
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Báo cáo Y học: Toxicity of novel C-terminal prion protein fragments and peptides harbouring disease-related C-terminal mutations pdf

Báo cáo Y học: Toxicity of novel C-terminal prion protein fragments and peptides harbouring disease-related C-terminal mutations pdf

... 121–146(AVVGGLGYMLGSAMSRPIIHFGSDYED), PrP147– 171(RYYRENMYRYPNQVYYRPVDQYSNQ), PrP163–184(RPVDQYSNQNNFVHDCVNITIK), PrP180– 198(NITIKQHTVTTKGENFT) and PrP196–220(NFTETDVKMMERVVRQMCVTQYQKE).CD spectroscopy ... previously described [3].Peptides or proteins were added to cultures initially and on the third day. Cell survival was determined on day5 or 7. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-tetrazo-lium ... Cereghetti2 and David R. Brown11Department of Biochemistry, Cambridge University, UK;2Institute of Molecular Biology and Biophysics, ETH-Hoeneggerberg, Zu¨rich,SwitzerlandMice expressing...
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Báo cáo y học: "Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy" pps

... SpA synovitis was characterized byhigher vascularity and infiltration with CD163+ macrophages and polymorphonuclear leukocytes (PMNs) and by lower valuesfor lining-layer hyperplasia, lymphoid ... cells,another type with diffuse infiltration by essentially T lym-phocytes and macrophages, and a third, granulomatoustype, which is less frequent [9]. The different histologicaltypes are ... diseases and fit well with thehypothesis that SpA synovitis is primarly driven by innateimmune cells with secondary alterations in lymphocyte acti-vation and functions [28].Independently of these...
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Báo cáo y học: "Adalimumab clinical efficacy is associated with rheumatoid factor and anti-cyclic citrullinated peptide antibody titer reduction: a one-year prospective study" potx

... atbaseline and after 6 and 12 months of treatment with adalimu-mab by using enzyme-immunoassay (EIA) (Pharmacia Diag-nostics, Friburg, Germany); positive samples were alsoevaluated by Farr assay and ... mg per day), 48 receivednon-steroidal anti-inflammatory drugs and/ or analgesics, and 6received other drugs. Patients were followed clinically at reg-ular intervals by the same physician during ... duration but not a specific treatment wasassociated with a decline in anti-CCP levels [39]. We did not find any variation in RF and anti-CCP antibody serum levels inthe group of patients with RA...
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Báo cáo y học: "Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase" potx

... Sanofi Synthelabo) isused to prevent acute uric acid nephropathy caused by tumorlysis in patients with leukemia and lymphoma [7,8]. However,the 18 hour half-life, which necessitates daily infusion, ... asparaginase and polyethylene glycol conjugated asparaginase for treat-ment of children with newly diagnosed standard-risk acute lymphoblastic leukemia: a Children's Cancer Group study.Blood ... evaluatingtherapy with poly(ethylene glycol)-modified uricase. J Am SocNephrol 2001, 12:1001-1009.14. Ganson N, Kelly SJ, Scarlett E, Sundy JS, Hershfield MS: Antibod-ies to polyethylene glycol (PEG)...
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Báo cáo y học: "Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis" pdf

... was estimatedafter incubation with an alkaline phosphatase-conjugatedswine anti-rabbit isotype-specific antibody (DakoCytomation,Glostrup, Denmark) and phosphatase substrate (Sigma-Aldrich, ... afterday 66 in wild-type mice. COMP deficiency led to early onsetof the disease, with a mean onset of arthritis at 37.5 ± 2.81days in COMP-deficient mice compared with 48.4 ± 13.7days in the ... COMP-deficient mice and wild-type mice mounted high-antibody tit-ers to CII. Antibody levels, however, were found to be similarin the COMP-deficient and wild-type mice at days 30, 130, and 160 (Figure...
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Báo cáo y học: "Archaeal phylogeny based on proteins of the transcription and translation machineries: tackling the Methanopyrus kandleri paradox" pdf

... adaptation to the very high intracellular salin-ity (1 M of cyclic 2,3-diphosphoglycerate) [23]. The resultingphylogeny was very similar to the transcription tree of Figure2a, with M. kandleri emerging ... represented the most basalbranch, with M. kandleri grouping paraphyletically with Methanococcales and Methanobacteriales (88% BP).Interestingly, M. kandleri displayed a very long branch in thetranscription ... identify and remove proteins affected by LGTby performing single phylogenetic analyses. We have previ-ously applied such a strategy to a dataset of ribosomal pro-teins used to retrace the phylogeny...
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