... Miguel J, Robak T, Dmoszynska A, Horvath N, Spicka I,Sutherland HJ, Suvorov AN, Zhuang SH, Parekh T, Xiu L, Yuan Z,Rackoff W, Harousseau JL: Randomized phase III study of pegylated liposomal doxorubicin ... signalingpathways, including the NF-κB pathway. Interestingly, many of the genes in these pathways are regulated by theproteasome [18]. Therefore, combined with our results, thismay also help explain why ... failure of manyorgan systems, including liver, kidney, heart and lungs, aftersystemic bacterial infection [1,5,6]. The pathogenesis of septicshock seems to be primarily governed by lipopolysaccharide(LPS)....