Wound Healing and Ulcers of the Skin - part 1 pps
Chapter 083. Cancer of the Skin (Part 1) ppt
... blacks, and East Asians have rates 10 –20 times lower than lighter-skinned whites. In keeping with the role of sun exposure, the incidence is inversely correlated with the latitude of residence; ... exceptions are benign. Examples of malignant and benign pigmented lesions are shown in Fig. 8 3 -1 . Figure 8 3 -1 Source: Adapted from AR Rhodes et al: JAMA 258: 314 6, 19 87. Persistently changing ... blacks, Asians, and Hispanics and occurs as an enlarging hyperpigmented macule or plaque on the palms and soles. Lateral Chapter 083. Cancer of the Skin (Part 1) Harrison's Internal...
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Chapter 083. Cancer of the Skin (Part 2) ppsx
... reddish brown, and often whitish pink, and the border of lesion is at least in part aDuring much of this time, the precursor stage, lentigo maligna, is confined to the epidermis. Source: ... Lentigo maligna melanoma Sun-exposed surfaces, 70 5–20a or longer In flat portions, shades of brown and tan particularly malar region of cheek and temple predominant, but whitish ... confined to chronically sun-damaged, sun-exposed sites (face, neck, back of hands) in older individuals. Acral lentiginous melanoma occurs on the palms, soles, nail beds, and mucous membranes. While...
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Chapter 083. Cancer of the Skin (Part 5) ppsx
... development of 6% has been estimated. The risk is greatest before age 5 and next greatest between ages 5 and 10 . Early detection of melanoma is difficult in these lesions because of the deep dermal ... origin of primary melanoma and because of the large and varied surface of the nevus. Prophylactic excision early in life can be accomplished by staged removal with coverage by split-thickness skin ... papillomatous surface. The border is sharp, and lesions may be oriented along lines of skin cleavage. Follicular hyper- and hypopigmentation may coexist in a salt -and- pepper ...
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Chapter 083. Cancer of the Skin (Part 10) pps
... Saunders, 19 91 ——— et al: Malignant melanoma in the 19 90s: The continued importance of early detection and the role of physician examination and self-examination of the skin. CA Cancer J Clin 1: 2 01, ... J Clin Oncol 19 :3635, 20 01 [PMID: 11 504745] Drake LA et al: Guidelines of care of basal cell carcinoma. J Am Acad Dermatol 26 :11 7, 19 92 [PMID: 17 32 317 ] ——— et al: Guidelines of care for cutaneous ... melanoma. JAMA 258: 314 6, 19 87 [PMID: 3 312 689] Chapter 083. Cancer of the Skin (Part 10 ) Other Nonmelanoma Cutaneous Malignancies Neoplasms of cutaneous adnexa and sarcomas of fibrous, mesenchymal,...
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Chapter 091. Benign and Malignant Diseases of the Prostate (Part 1) pps
... Testosterone, the major circulating androgen, is converted by the enzyme 5 - reductase to dihydrotestosterone in the gland. The periurethral portion of the gland increases in size during puberty and after ... prospective randomized trials. The paradox of management is that although the disease remains the second leading Chapter 0 91. Benign and Malignant Diseases of the Prostate (Part 1) Harrison's ... males. PIN, the precursor of cancer, is typically multifocal and highly unstable. Polymorphic variants of the androgen receptor gene, the cytochrome P450 C17 gene, and the steroid 5 - reductase...
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Chapter 085. Neoplasms of the Lung (Part 1) pps
... carcinoma 0 .1 <0 .1 39 Adenoid cystic carcinoma <0 .1 <0 .1 48 Sarcoma and other soft tissue tumors 0 .1 0 .1 30 All others and unspecified carcinomas 11 .0 6 NA Total 10 0 52 14 aData ... frequency and age-adjusted incidence rates per 10 0,000 U.S. population are from 60, 514 cases of invasive lung cancer involving all races and both sexes obtained from the data for 19 83 19 87 of the ... Adenocarcinoma (and all subtypes) 32 7 17 Bronchioloalveolar carcinoma 3 1. 4 42 Squamous cell (epidermoid) carcinoma 29 15 15 Small cell carcinoma 18 9 5 Large cell carcinoma 9 5 11 Carcinoid 1. 0...
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Chapter 127. Treatment and Prophylaxis of Bacterial Infections (Part 1) ppsx
... bacteremia). The mechanisms of action of the antibacterial agents to be discussed in this section are summarized in Table 12 7 -1 and are depicted in Fig. 12 7 -1 . Table 12 7 -1 Mechanisms of Action of and ... defined aCompounds in parentheses are major representatives for the class. Figure 12 7 -1 Chapter 12 7. Treatment and Prophylaxis of Bacterial Infections (Part 1) Harrison's Internal ... appropriately, these drugs are lifesaving. However, their indiscriminate use drives up the cost of health care, leads to a plethora of side effects and drug interactions, and fosters the emergence of...
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Chapter 083. Cancer of the Skin (Part 4) pot
... areas; the back is the most common site, but dysplastic nevi may also be seen on the scalp, breasts, and buttocks Generally on the sun-exposed surfaces of the skin above the waist; the scalp, ... lymph nodes and palpation of the abdominal viscera are part of the staging examination for suspected melanoma. The patient should be advised to have other family members screened if either melanoma ... pigment may fade off into surrounding skin; macular portion at the edge of the nevus Round; sharp, clear-cut borders between the nevus and the surrounding skin; may be flat or elevated Size...
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Chapter 083. Cancer of the Skin (Part 6) potx
... cells and minimize possible local recurrence. The appropriate width of the margin is a source of controversy. A World Health Organization trial that prospectively randomized between 1- and 3-cm ... Cancer of the Skin (Part 6) Biopsy Any pigmented cutaneous lesion that has changed in size or shape or has other features suggestive of malignant melanoma is a candidate for biopsy. The recommended ... feasible (such as the face, hands, or feet), an incisional biopsy through the most nodular or darkest area of the lesion is acceptable; this should include the vertical growth phase of the primary...
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Chapter 083. Cancer of the Skin (Part 7) doc
... on the lower lip. Sun-exposed skin such as the head, neck, hands, and arms are other typical sites of involvement. C. Actinic keratoses consists of hyperkeratotic erythematous papules and ... sun-exposed skin. They arise in middle-aged to older adults and have some potential for malignant transformation. D. Metastatic carcinoma to the skin is characterized by inflammatory, often ... vinblastine, and vindesine; the taxanes paclitaxel and docetaxel; IFN-α; and interleukin 2 (IL-2). Although limited in efficacy, single-agent dacarbazine is still considered the standard treatment....
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