... PC12 cellsMutsuya Yamamoto, Takeshi Hioki, Takehisa Ishii, Sadayo Nakajima-Iijima and Shigeo Uchino*Pharmaceuticals Discovery Laboratory, Yokohama Research Center, Mitsubishi-Tokyo Pharmaceuticals ... and physiological orpathological neuronal cell death. However, it is not knownwhether DAP kinase activity is critical for neuronal celldeath.Ceramide, generated by sphingomyelin hydrolysis, ... apoptosisand necrosis. However, it is not known whether the k inaseactivity is involved in apoptosis. In the present study, weemployed PC12 cells, extensively used as a model to studymechanisms regulating...