Ophthalmic Drug Delivery Systems - part 5 doc

... anterior chamber (52 ,53 ) generally exhibit half-liveswithin a range of 20–30 hours (53 ). The second route is through the retinavia penetration of the blood-retinal barrier (52 ,53 ). Drugs eliminated ... sensitivityof drug distribution and elimination using the model. Therefore, the diffu-sivities used in the model simulations are 2:4 Â 10 5 cm2/s (1 25 Da), 5: 6 Â10À6cm2/s ( 354 Da), and 5: 4 Â ... injection,increased as the drug diffusivity was reduced. Furthermore, the rate of drug elimination, which is inversely related to the drug s elimination half-life, decreased significantly as the drug diffusivity...

... R.(1998). Ophthalmic drug delivery systems recent advances, Prog. Retinal EyeRes., 17:33 58 . 95. Robinson, J. C. (1993). Ocular anatomy and physiology relevant to ocular drug delivery. Drugs Pharm. ... of endotoxin-induced-uvei-tis in rats. Exp. Eye Res., 65: 533 54 5.68. Pagano, G., Bruno, A., Cavallo-Perin, P., Cesco, L., and Imbimbo, B. (1989).Glucose intolerance after short-term administration ... of drugs in perspective vis-a-vis ocular drug delivery. First, the noncorneal penetration pathway involves the per-meation of drug across the conjunctiva and sclera and may contribute sig-nificantly...

... on isolated non-pregnant myometrium and uterinearteries and their inhibition by deamino-ethyl-lysine-vasopressin and dea-mino-ethyl-oxytocin, Br. J. Obstet. Gynaecol., 90:732. 5. Vilhardt, H., ... production of fibroblast growth factors fgf-2,fgf -5 , and fgf-18 (30,31), while lens epithelium-derived growth factor pro-moted photoreceptor survival in light-damaged and RCS rats, but not inP23H ... nearfuture. We hope that novel drug delivery systems will be developed todeliver potent polypeptide drugs through the ocular route.REFERENCES1. Lee, V. H. L. (1987). Ophthalmic delivery of peptides...

... 2.7 timesfor befunolol0 .5% FD-4, FD-10 Rabbit Enhanced Papp 100 times for FD-4 and114 times for FD-10.FD-4: FITC-dextran (average molecular weight 4400); FD-10: FITC-dextran (average molecular ... Enhanced Papp 5. 2 5. 5 times10 mM 6-Carboxyfluorescein Rabbit Enhanced penetrated amount 59 3 times2–10 mM FD-4 Rabbit Enhanced penetrated amount 30.9–61 .5 timesUrodeoxycholic acid 0. 05% Atenolol, ... fordexamethasone0.00 25 0. 05% Fluorescein Rabbit,HumanEnhanced permeability significantly overat 0.0 05% Benzyl alcohol 0 .5% Tilisolol, FD-4, FD-10Rabbit Enhanced Papp 2.6 times for FDA and8.1 times for FD-10Chlorbutanol...

... including polymer -drug complex sys-tems, erodible microspheres, responsive particulates, in situ gelling systems, ion-exchange systems, and nanoparticles ( 15) .B. Local Injectable Systems When the ... 10 (IL-10) under the control of -myosinheavy chain promoter (-MHC-vIL-10) injected into the graft prolongedallograft survival significantly from 13.9 days to 21.4 days. When - MHC-vIL-10 was ... Inc.II. PARTICULATE SYSTEMS IN OCULAR DRUG DELIVERY A. Topical Systems The isolation of the vitreous caused by the blood-retinal and blood-aqueousbarriers creates difficulties for effective drug therapy...

... andcytotoxicity of a series of 5 0-ester prodrugs of 5- iodo-20-deoxyuridine. Pharm.Res. 5: 734–737, 1988.10 Macha et al.Copyright © 2003 Marcel Dekker, Inc. Ophthalmic Drug Delivery Systems Second Edition, ... effective ophthalmic drug delivery systems, but the knowledge in this field is rapidlyexpanding. Systems range from simple solutions to novel delivery systems such as biodegradable polymeric systems, ... Inc.fusionpointsoftheNPEcellsblockfurthermovementofHRPintotheposteriorchamber(Schlingemannetal.,1998).Gapjunctionsareubiquitousintheciliarybodyepithelium,connectingPE-to-PE,NPE-to-NPF,andPE-to-NPEcells(Freddo,1987)(Fig.6).ThegapjunctionsbetweenPEandNPE cells are permeable to molecules at least as large as 900–1000 daltons(Spray and Bennett, 19 85) .In...