... 5.83E16 7 17 0165
C R ≤−0333 @
59HzR= 01
@ 370 –400 Hz
20 7. 63E16 −698 038 17
52 Introduction and Background
variability from material to material, scatter in the data, and lack of sufficient ... the
shape of the Haigh diagram based on the experimental data. The mean stress model
predicts a mean stress of 32.5 ksi independent of R for 10
7
cycles at 59 Hz since the model
i...
... Chapter 005. Principles of Clinical
Pharmacology
(Part 1)
Harrison's Internal Medicine > Chapter 5. Principles of Clinical
Pharmacology
Principles of Clinical Pharmacology: Introduction ... of the target molecule itself or of variability in the broad biologic context
in which the drug-target interaction occurs to achieve drug effects.
Two important goals of...
... 005. Principles of Clinical
Pharmacology
(Part 4)
Clinical Implications of Drug Distribution
Digoxin accesses its cardiac site of action slowly, over a distribution phase
of several hours. ... volume of distribution of lidocaine is reduced. Therefore, lower-than-
normal loading regimens are required to achieve equivalent plasma drug
concentrations and to avoid toxicity...
... Chapter 005. Principles of Clinical
Pharmacology
(Part 7)
Renal Disease
Renal excretion of parent drug and metabolites is generally accomplished
by ... in the elderly because of
altered pharmacokinetics and pharmacodynamics, the frequent use of multidrug
regimens, and concomitant disease. For example, use of long half-life
benzodiazepines ... of lidocaine is
reduce...
... target of QT-
Chapter 005. Principles of Clinical
Pharmacology
(Part 9)
Transferase Variants
One of the most extensively studied phase II polymorphisms is the PM trait
for thiopurine S-methyltransferase ... Deficiency of glucose- 6-
phosphate dehydrogenase (G6PD), most often in individuals of African or
Mediterranean descent, increases risk of hemolytic anemia in re...
... cimetidine decreases the renal clearance of
dofetilide and of procainamide and its active metabolite NAPA.
Chapter 005. Principles of Clinical
Pharmacology
(Part 11)
Pharmacokinetic Interactions ...
penetration of multiple HIV protease inhibitors (with the attendant risk of
facilitating viral replication in a sanctuary site) appears attributable to P-
glycoprotein-med...
... Internal Disease
(Part 7)
Telangiectasias
(Table 5 4-8 ) In order to distinguish the various types of telangiectasias, it is
important to examine the shape and configuration of the dilated blood ... of patients with actinically damaged
skin and acne rosacea, and they are found on the legs of patients with venous
hypertension and essential telangiectasia. Patients with an...
... gram-positive bacteria and
cell-surface products of mycobacteria and spirochetes can interact with CD14
(Fig. 11 4-3 ). Additional molecules, such as MD-2, also participate in the
recognition of ... mechanisms
of microbial pathogenesis (Fig. 11 4-3 ). One of the best-studied systems involves
the interaction of LPS from gram-negative bacteria and the
glycosylphosphatidylinos...
... of telephone and office management
of vulvovaginal symptoms has documented the inaccuracy of the former, and
comparison of evaluations by nurse-midwives with those by physician-
practitioners ...
pseudomycelia
in up to 80%
of C. albicans
culture-
positive
persons with
typical
symptoms
trichomonads
seen in 80–
90%
of symptomatic
patients, less
often in the
absence of...