... habil. 1987) is professor of
English language and linguistics at the University of Ło
´
dz
´
, where she holds the
position of professor ordinarius and chair of the Department of English Language.
Her ... president of the
Polish Cognitive Linguistics Association since 20 02. Barbara Lewandowska-To-
maszczyk can be reached at blt@uni.lodz.pl.
ricardo maldonado (PhD 19 92) is profe...
... CYP3A4, CYP3A5, CYP2D6, CYP2C9,
CYP2C19, CYP1A2, and CYP2E1, and each drug may be a substrate for one or
more of these enzymes. "Phase II" metabolism involves conjugation of specific
other ... the product of the
normal expression of the MDR1 gene. P-glycoprotein is expressed on the apical
aspect of the enterocyte and on the canalicular aspect of the hepatocyte (Fig....
... distributed, with about 7% of
European- and African-derived populations (but very few Asians) displaying the
PM phenotype (Fig. 5-6 ). Dozens of loss -of- function variants in the CYP2D6 gene
have been ... loss -of- function variants, especially in African-derived populations.
CYP3A refers to both enzymes.
CYP2D6 is second to CYP3A4 in the number of commonly used drugs that
it m...
... genetics, clinical trials, and the educated prescriber all
Chapter 005. Principles of Clinical
Pharmacology
(Part 14)
Diagnosis and Treatment of Adverse Drug Reactions
The manifestations of drug-induced ... manifestations of drug-induced diseases frequently resemble those of
other diseases, and a given set of manifestations may be produced by different and
dissimila...
... benefits of the performance of these
Chapter 091. Benign and Malignant
Diseases of the Prostate
(Part 2)
Diagnosis and Treatment by Clinical State
The disease continuum—from the appearance of ...
18.4% (803 of 4364) in the finasteride group and 24 .4% (1147 of 46 92) in the
placebo group. Early concerns that the cancers detected in the finasteride group
were high-g...
... addition of subunits to the
peptidoglycan backbone.
β-Lactam Antibiotics
β-Lactam antibiotics (penicillins, cephalosporins, carbapenems, and
monobactams; Table 12 7 -2 ) are characterized by a four-membered ... cleavage of a terminal D-alanine residue
from the subunit stem peptide. The cross-bridge amino acid is then attached to the
penultimate D-alanine by transpeptidase enzymes....