... arthros-copy, and analyzed gene-expression profiles in the synovial lin-ing tissues selected by LCM in a cDNA microarray bycomparing those in multilayered lining tissues with those in normal-like lining ... fixed with 10%formalin in 0.01 mol/l phosphate buffer, pH 7.2, and embed-ded in paraffin wax. They were stained with hematoxylin and eosin for examination by light microscopy. Histopathologicalparameters ... lining layers, non-foreign-body-typegiant cells in the lining regions, lymphoid and plasma cell infil-tration, neovascularization, mesenchymoid transformation, and fibrinoid necrosis in synovium....