... of inducing otherproinflammatory cytokines and activating matrix metalloprotei-nases in autocrine and paracrine fashions [2]. Inhibitors of IL-1 and TNF-α cause a reduction in synovial inflammation, ... HY, Huang HC, Ko CH, Yang LL, Chen YC: In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production. ... traditionallyhave been used for pain and vascular protection [11]. Querce-tin inhibits inflammatory reactions by regulating the generationof inflammatory cytokines such as IL-6, TNF-α, and interferon-gamma...