... histonemodification may influence another by recruiting oractivating chromatin-modifying complexes [27]. How-ever, a study in yeast revealed only simple and cumula-tive functional consequences for combinations ... the chromatin features areredundant, and to what extent they are interac ting in acombinatorial fashion. Specifically, for each bin, wemodeled the expression level y as a linear combinationof ... ofindividual types. As shown in Figure 5a, the AUCobtained by using all features (black) is comparable tothe AUCs obtained from models using only particularsubsets of fe atures. Strikingly,...