Báo cáo y học: "High resolution discovery and confirmation of copy number variants in 90 Yoruba Nigerians" pdf

... examined known copy number variants in 10 Yoruba using Agilent microarrays; and in the Wang et al. [15]study, 36 Yoruba were genotyped using Illumina BeadChips.For each Yoruba individual in common ... CNVs, and type large numbers of individuals in order to gain biological insights beyond the initial discovery. Materials and methodsArray synthesisArrays were synthesized following standard Affymetrix ... R125ResearchHigh resolution discovery and confirmation of copy number variants in 90 Yoruba NigeriansHajime Matsuzaki, Pei-Hua Wang, Jing Hu, Rich Rava and Glenn K FuAddress: Affymetrix, Inc., 3420...

Báo cáo khoa học: High resolution structure and catalysis of O-acetylserine sulfhydrylase isozyme B from Escherichia coli pot

... into catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuber-culosis: crystal structures of the enzyme-a-aminoacrylateintermediate and an enzyme–inhibitor complex. ... stability of the protein. Consequently, theFig. 4. Stereoview of a superposition of ﬁvedistinct CysM chain folds showing wild-typeCysM in blue [6], CysM(RKE) subunit A in green, CysM(RKE) ... subunit D in orange [6],CysM(K268A) in red and CysM(salmo) in gray [18]. The highly mobile regions arelabeled using gray spheres (see Fig. 5).Structure of the O-acetylserine sulfhydrylase CysM G....

Báo cáo y học: "Pulmonary stenosis development and reduction of pulmonary arterial hypertension in atrioventricular septal defect: a case report" pdf

... stenosis.ConsentWritten informed consent was obtained from the patientfor publication of this case report and accompanyingimages. A copy of the written consent is available forreview by the Editor -in- Chief of ... angiography 2008: dynamic infundibular pul-monary artery stenosis during blood flow ejectionFigure 4Right ventricular angiography 2008: dynamic infundibular pulmonary artery stenosis during blood ... haemodynamicparameters have been re-evaluated in 2006 and 2008.They highlighted a late and progressive development of a valvular and infundibular pulmonarystenosis leading to a normalisation of...

Báo cáo y học: "Community transcriptomics reveals universal patterns of protein sequence conservation in natural microbial communities" pdf

... significantly less abundant in the RNA, beinginvolved in 61% of all decre asing DNA-RNA amino acidfrequency changes. In contrast, frequency increases weredominated by amino acids enriched in GC: 50% of increases ... richness in expressedgenes is potentially driven by a combination of factors,including selection against metabolically costly aminoacids (for example, AT-enriched phenylalanine and tyro-sine) ... Bacterial motility proteins [BR:ko02035] 00860 Porphyrin and chlorophyll metabolism [PATH:ko00860] 00 290 Valine, leucine and isoleucine biosynthesis [PATH:ko00 290] 00240 Pyrimidine metabolism...

Báo cáo y học: "High-Resolution Flow Cytometry: a Suitable Tool for Monitoring Aneuploid Prostate Cancer Cells after TMZ and TMZ-BioShuttle Treatment"

... therapy using siRNA targeting Bcl-xL and cisplatin against prostate cancer. Int. J. Cancer 2009;125(12):2978 -90 41. Cherry J, Karschner V, Jones H, and Pekala PH. HuR, an RNA-binding protein, involved ... toxicity and poor response [19]. Despite initially encouraging results of tumor growth control were reported in other tumor types than brain tumors [20], the results of a phase II study of TMZ in ... closeness was declined and accompanied with an in- crease of amount of dead cells in the supernatant. Using the flow cytometry technique not only a differentiation in the cell cycle state of DU 145...

Báo cáo y học: "High resolution transcriptome maps for wild-type and nonsense-mediated decay-defective Caenorhabditis elegans." potx

... C. elegans, in particu-lar in the analysis of splicing and RNA stability.Materials and methodsStrain maintenance and RNA preparation and processingC. elegans strains were maintained on NGM ... particular, many PTCs areintroduced by splicing errors [29,31,32,40,49,50], includingintron retention and the incorrect retention or skipping of exons, and we examined these individually and show ... Nonetheless, mapping the wild-type transcriptomeitself identified a number of interesting findings and novelfeatures.First, we find that both sequencing and tiling analysis yieldedvery similar transcriptome...

Báo cáo y học: "High-resolution optical coherence tomographic imaging of osteoarthritic cartilage during open knee surgery" ppsx

... 4a) and the correspond-ing histology (Fig. 4b) of severely diseased cartilage. Dis-tinctive thinning of the cartilage was observed only on theleft portion of both OCT image and histology. In ... described in detail pre-viously [9,10]. A schematic drawing of the OCT systemused in this study is shown in Fig. 1a. In this study, a novel,compact, handheld OCT imaging probe capable of per-forming ... spectroscopy [11-13].Preliminary work demonstrated the feasibility of OCT in assessing joint cartilage pathologies in vitro [11,14].Microstructures such as fibrillations, cartilage thinning, and new...

Báo cáo y học: " High-resolution transcription atlas of the mitotic cell cycle in budding yeast" pptx

... transcription of intergenic regions and theantis ense strands of hundreds of annotated protein-cod-ing genes occurs in budding yeast, despite it lacking ves-tiges of the protein machinery required ... showsigns of phase-specific splicing; hence, in contrast tomeiosis in budding and fission yeast [49,50], we see noevidence for a regulatory role of splicing in the mitoticcell cycle of budding yeast.ConclusionsOur ... benchmark sets of 113 known cycl ing genes i dentified in single-gene stu-dies [47]. A combined list of cycling t ranscripts wascompiled that contains all transcripts identified ascycling b y at least...

Báo cáo y học: " hzAnalyzer: detection, quantification, and visualization of contiguous homozygosity in high-density genotyping datasets" doc

... detection of runs of homozygous and heterozygous genotypes; 2)joining of neighbouring homozygous segments acrossregions of low SNP d ensity; 3) modeling of detectedhomozygous and heterozygous ... frequency of homozygous segments with haplotypes underlying extAUCpeaks. Analysis of the consistency of the homozygous extent distribution and length and frequency of haplotypes for extAUCpeaks in ... underlying fre-quency of inferred haplotypes [9,13], and the totalextent of contiguous homozygosity (segments greaterthan 1 Mb in l ength) was recently used to assist in theanalysis of the...

Báo cáo y học: " High recombination rates and hotspots in a Plasmodium falciparum genetic cross" docx

... microarray experiments, data analysis, and writing; NL, VG, SV, VN, MY, and RS, data analysis; MZ, data analysis and writing; JM and JL, MS typing;KH and TEW, genetic cross and writing; BH, ... Many factors can influ-ence estimates of RR (or more precisely outcrossingrate), including the intensity of transmission by mosqui-toes, diversity o f local parasite populations, the number of ... Allergy and Infectious Diseases, National Institutes of Health. Wethank Jun Yang and Brandie Fullmer at the Laboratory of Immunopathogenesis and Bioinformatics, SAIC-Frederick, Inc. for microarrayhybridizations,...

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