Báo cáo y học: "START lipid/sterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factors" potx
Báo cáo y học: "START lipid/sterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factors" potx
... lipid/sterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factors<p>A survey of proteins containing lipid/sterol-binding StAR-related ... lipid/sterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factorsKathrin Schrick*, Diana Nguyen*, Wojciech M Karlowski† and Klaus FX Mayer†Addresses: ... directly by affecting its DNA-binding affinity or inter-action with accessory proteins at the promoter. Alternatively,or in addition, protein-lipid/sterol binding may positively ornegatively affect...
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Báo cáo y học: "Differential responsiveness to immunoablative therapy in refractory rheumatoid arthritis is associated with level and avidity of anti-cyclic citrullinated protein autoantibodies: a case study" pps
... erosive disease,including large joint involvement, and were refractory to com-bination therapy with DMARDs and, in four patients, with tumour necrosis factor (TNF)-blocking agents. Heparinizedwhole ... treatment and compared with the avidity of TTantibodies following repeated immunizations. Synovial biopsieswere obtained by arthroscopy before HDC plus HSCT, and analyzed by immunohistochemistry. In ... diseases, it is currently unclear why HDC plusHSCT exhibited inferior efficacy in RA.A common finding in autoimmune diseases is activation ofautoreactive B lymphocytes, resulting in the formation...
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Báo cáo y học: "Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis" pot
... complementarity-determin-ing region (CDR3)- typing of T cells infiltrating the joints hasbeen used, aiming to identify clones that are specificallyenriched in the inflamed synovia. Some CDR3- ... cells) are shown. (Panel a) Treg cells are 1.33% and 2.9% in the total lymphocyte population and within the CD4+ subset, respectively. (Panel b) Treg cells are efficiently removed (0.05% and ... between brightly and dimly stainedCD25+ cells (CD25high and CD25int, respectively), all flowcytometric analyses were reviewed by one investigator (AB)who was blind to sample identity. Cells...
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Báo cáo y học: " Introduction of Medical Emergency Teams in Australia and New Zealand: a multi-centre study"
... recording information oncritical care resources, including the timing of introduction ofMETs. In addition, ANZICS maintains an Adult Patient Data-base (ANZICS-APD), which currently contains information ... undertaken using theinformation contained within the database.Assessment on timing of introduction of MET serviceWe obtained information from a database maintained by theANZICS ARCCCR and derived ... Emergency Team (MET) status of 172 hospitals in Australian and New Zealand with intensive care units. The diagram does not include hospitals participating in the Medical Emer-gency Response and Intervention...
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Báo cáo Y học: The proximal cis-acting elements Sp1, Sp3 and E2F regulate mouse mer gene transcription in Sertoli cells potx
... Sp3.Receptor tyrosine kinases (RTKs) are cell surface receptorsthat contain intrinsic protein tyrosine kinase activity in theircytoplasmic regions. They are responsible for transmittingsignals from ... activity in TM4 cells. Within this region, fourprotein-binding sites were detected by DNase I footprinting and gel shift assays. Three of them contained Sp1 cis-actingmotifs, which are located ... Rse and Mer are classified into the Tyro 3 RTKsubfamily. Receptors in the Tyro 3 subfamily share adistinctive extracellular region of two immunoglobulin-related domains linked to two fibronectin...
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Báo cáo Y học: Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles A possible role in membrane secretion pptx
... abundantly in lactating mammary glands and is secreted in association with fat globules. This protein consists of two-repeated EGF-l ike domains, a mucin-like domain and two-repeated discoidin-like domains ... detected in various other tissues, including brain, lung, heart, kidney and spleen in some mammals such as mouse, human and bovine [7–9]. The mouse and bovine MFG-E8 proteinsexpressed in mammary gland ... or with methanol chilledat )20 °C for 5 min for intracellular staining. After blocking with NaCl/Picontaining 2% BSA (blocking solution) for30 min, the specimens were incubated for 60 min with...
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Báo cáo Y học: Expression of uncoupling protein-3 in subsarcolemmal and intermyofibrillar mitochondria of various mouse muscle types and its modulation by fasting docx
... notnecessarily result in similar changes at the protein level and indicate that UCP3 density in SS and IMF mitochondria canbe differently affected by metabolic changes.Keywords: fasting; intermyofibrillar ... Kuhne,Pierre Flandin, Jean-Paul Giacobino and Patrick MuzzinDepartment of Medical Biochemistry, Faculty of Medicine, University of Geneva, SwitzerlandUncoupling protein-3 (UCP3) is a mitochondrial inner-membrane ... implications for the understandingof its physiological role. In conclusion, in this study, using a carefully validatedantibody to UCP3 and a new protocol to prepare SS and IMF mitochondria, UCP3...
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Báo cáo y học: "Falling into TRAPS – receptor misfolding in the TNF receptor 1-associated periodic fever syndrome" ppsx
... leaving TNFα-induced NF-κB activation intact. ER-retained oligomers mayindependently activate novel signalling pathways leading toinflammation, may modify ER stress-induced responses, or may ... studied.Conversely, the effect of TNFR1 mutations outside immunecells also needs to be examined. Understanding the signallingpathways connecting protein misfolding and inflammation willbe interesting in ... Gadina M, Karenko L, Petters-son T, et al.: Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of domi-nantly inherited autoinflammatory syndromes....
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Báo cáo y học: "Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia" docx
... 'sympathetically maintained pain'[5].Naturally occurring sympathetic neurotransmitters are cate-cholamines known as norepinephrine, epinephrine, and dopamine. All three substances act within the ... Diatchenko and colleagues [10] also demonstrated that COMT inhibition in rats results in a dramatic increase in sensitivity to pain. LowCOMT activity may increase pain sensitivity by activating beta(2/3)-adrenergic ... variation. By combining these SNPs,Diatchenko and colleagues [10] were able to identify frequentCOMT gene haplotypes strongly associated with sensitivity toexperimental pain and induction of...
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Báo cáo y học: " Insights into endocrine-immunological disturbances in autoimmunity and their impact on treatment" doc
... concentrations,respectively, are modulated by hormones and neuronalpathways coordinated by a subordinate neuroendocrinecentre in the hypothalamus, which follows a strict 24-hourdaily cycle.The closest similarity with ... diseases[16].Insights into neurohormonal effects ofmelatonin in autoimmunityMLT is an important neurohormone mainly synthesized by thepineal gland with a circadian rhythm that peaks between01:00 and ... circadian increase of proinflammatorycytokine levels, and therefore the consequently observedclinical signs and symptoms of the disease, than to treatthese signs and symptoms once they are established...
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