... chromosomaltranslocation, one of the most important cytogeneticabnormalities of MCL, juxtaposes genes of cyclin D1and of immunoglobulin heavy chain, inducing cyclin D1over-expression and cell ... mammalian Target Of Rapamycin (mTOR) is aserine/threonine protein kinase. It plays an importantrole in cell growth, protein synthesis, and cell- cycle pro-gression [4]. Since mTOR pathway ... of Medicine, Shanghai, China2Inserm, U728, Pôle de Recherches Franco-Chinois, Paris, FranceFull list of author information is available at the end of the articleWang et al. Journal of Hematology...