Báo cáo khoa hoc:" EM-REML estimation of covariance parameters in Gaussian mixed models for longitudinal data analysis" docx

Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

... control was maintained in a standard incubator with 21% O2. The normoxia data are the same as shown in Fig. 1 and are included here for comparison. Expression of miR-2 7a and miR-27b at the indicated ... overexpression, indicating that miR-27 does not play an important role in myogenicdifferentiation. Taken together, these results illustrate a critical and speciﬁc role of miR-27 in the regulation of adipogenic ... Dharmacon, Lafayette, CO, USA). Usingquantitative real-time PCR analysis, we found a > 60-fold increase in mature miR-2 7a and miR-27b in the transfected preadipocytes. As shown in Fig. 2A, miR-2 7a, ...

Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf

... 945 The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation Heath Ecroyd and John A. CarverSchool of Chemistry and ... signiﬁ-cantly increased the chaperone activity of aB-crystallin (84 ± 4%) against this target protein. The effect of Arg-HCl on the structure and assembly of aB-crystallin We investigated whether the effects ... Gdn-HClhad no effect on the chaperone activity of aB-crystal-lin against the DTT-induced aggregation and precipi-tation of insulin.ACBFig. 2. aB-crystallin protects against the DTT-induced aggregation...

Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx

... models or in the surroundings of the mutated residues. The models of RNase A covalent dimers in the exchanging conformation were prepared using the 7RSA structure and the structure of exchanging BS-RNase(1BSR) ... Nter are the C-terminal and N-terminal structural regions,respectively, of the two A and B monomers of the dimeric RNase. The black circle between the monomers indicates the mass center of the dimer.E. ... ª 2006 The Authors Journal compilation ª 2006 FEBS 3693 The role of electrostatic interactions in the antitumor activity of dimeric RNases Eugenio Notomista1, Jose´Miguel Manchen˜o2,...

Tài liệu Báo cáo khoa học: Structural characterization of Ca2+/CaM in complex with the phosphorylase kinase PhK5 peptide pdf

... substratebinding sites. In the case of the titin and twitchinkinases, the autoinhibitory sequence acts as a pseudo-substrate, occluding ATP binding and preventingprotein substrates from binding ... CaM. However in PhK5 Trp357 is foundat the C-terminal end of the peptide. This suggeststhat either PhK5 might bind with Trp357 in the N-terminal site in CaM, or perhaps could bind in the opposite ... protein kinases are regulated throughan autoinhibitory mechanism [8]. In these structures aC-terminal extension to the protein kinase folds backon the kinase domain and interferes with the...

Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafﬁcking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efﬁcient GABA-uptake activity of the GABA transporter pptx

... (2005) 16 2 516 38 ê 2005 FEBS 16 31 The role of N-glycosylation in the stability, trafficking and GABA- uptake of GABA- transporter 1 Terminal N-glycans facilitate efficient GABA- uptake activity of the GABA ... N-linked oligosaccharide side-chainsare important for the GABA transport activity. 1- Deoxymannojirimycin inhibits the GABA- uptake of GAT1 In order to gain further insight into the role of the terminal ... terminal structure of the oligosaccharides facilitate efficient GABA- uptake activity of the GABA transporter. Defective N-glycosylation results in reduction of the stability of GAT1 In order to study the in uence...

Tài liệu Báo cáo khoa học: Quantitative estimation of channeling from early glycolytic intermediates to CO2 in intact Escherichia coli pdf

... Quantitation of channeling in intact E. coli FEBS Journal 272 (2005) 32603269 ê 2005 FEBS 3263 Quantitative estimation of channeling from early glycolytic intermediates to CO2 in intact Escherichia coli Georgia ... Argininosuccinate synthe-tase and argininosuccinate lyase are localized aroundmitochondria: an immunocytochemical study. J CellBiochem 60, 334–340.Quantitation of channeling in intact E. coli ... glycolytic intermediates to CO2 in intact Escherichia coli. Cellsincubated with [14C]glucose made14C-labeled glyco-lytic intermediates. When the incubation mix alsoincluded a [12C]intermediate,...

Tài liệu Báo cáo khoa học: Improving Classification of Medical Assertions in Clinical Notes" pdf

... system. 4.1 Data The training set includes 349 clinical notes, with 11,967 assertions of medical problems. The test set includes 477 texts with 18,550 assertions. These assertions were distributed ... the training data to measure the impact of each of the four subsets of features explained in Section 3. Ta-ble 3 shows the cross validation results when cu-mulatively adding each set of features. ... by manually examining the training data: Lexical Features: The medical term itself, the three words preceding it, and the three words fol-lowing it. We used the LVG annotator in Lexical Tools...

Tài liệu Báo cáo khoa học: "Topological Ordering of Function Words in Hierarchical Phrase-based Translation" pdf

... NN = 2048N = 128N = 64N = 2048331 Proceedings of the 47th Annual Meeting of the ACL and the 4th IJCNLP of the AFNLP, pages 324–332,Suntec, Singapore, 2-7 August 2009.c2009 ACL and AFNLP1...

Tài liệu Báo cáo khoa học: Enhanced expression of Mcm proteins in cancer cells derived from uterine cervix docx

... level of Mcm expression in HeLa cells and cancer cells from human uterine cervix. Although it remains to be determined how enhanced expression of Mcm proteins affects DNA replication in cancer cells, ... in cancer cells derived from uterine cervix and in HeLa cells. The expression of Mcm genes in growth-arrested cells isinduced by addition of serum [43]. There are several E2Fbinding sites in ... 2003 Mcm3 and 4 in cancer cells than in normal proliferating cells of human uterine cervix and dysplastic cells. The resultssuggest that enhanced expression of Mcm proteins plays arole in the...

Tài liệu Báo cáo khoa học: "THE REPRESENTATION OF INCONSISTENT INFORMATION IN A DYNAMIC MODEL-THEORETIC SEMANTICS" ppt

... usually infinite. Dynamic models are incomplete models that include only the information needed for an application and to which information can be added. Dynamic models are basically approximations ... Model-theoretic semantics provides a computationally attractive means of representing the semantics of natural language. However, the models used in this formalism are static and are usually ... This mechanism is a correlate of that of Thomason [1980], with the addition of meaningful names to intensional objects serving the same purpose as Thomason's additional layer of types....

Tài liệu Báo cáo khoa học: "Automatic Detection of Nonreferential It in Spoken Multi-Party Dialog" doc

... written text, and it contains signiﬁcantly more instances of it, includ-ing some types of nonreferential it not found in written text.3.1 The ICSI Meeting CorpusThe ICSI Meeting Corpus (Janin ... available during training or test-ing. With this setting, the classiﬁer achieved a re-call of 55.1%, a precision of 71.9% and a resultingF-measure of 62.4% for the detection of the class nonreferential. ... Identifyingnon-referential it: a machine learning approach incor-porating linguistically motivated patterns. In Proceed-ings of the ACL Workshop on Feature Selection for Ma-chine Learning in NLP,...

Tài liệu Báo cáo khoa học: "The Use of Shared Forests in Tree Adjoining Grammar Parsing" pptx

... parsing of tree adjoining grammars with particular emphasis on the use of shared forests to represent all the parse trees deriving a well-formed string. We show that there are two distinct ... studying tag parsing. The schemes using lig and cfg to represent parses can be seen to underly most of the existing tag parsing algorithms, 1 Introduction We study parsing of tree adjoining grammars ... ways of representing the parse forest one of which involves the use of linear indexed grammars and the other the use of context-free grammars. The work presented in this paper is intended...

Báo cáo khoa học: Quantitative modeling of triacylglycerol homeostasis in yeast – metabolic requirement for lipolysis to promote membrane lipid synthesis and cellular growth potx

... as sources oras sinks for internal fluxes. From a biological point of view, they allow the cell to dispose of excessmetabolites by storing them in an inert form. Whendemand for these metabolites ... – that lipolysis of TAG is a key process duringlag and pre-logarithmic growth phases (Fig. 2), and promotes the rapid initiation of growth of quiescentcells exposed to glucose-containing media. ... the role of TAGdegradation in growing cells and the metabolic flux of FA. We reconstructed the metabolic pathway of TAG lipolysis in yeast in silico and specifically addressed thequestion of whether...

Báo cáo khoa học: "The use of caspase inhibitors in pulsed-field gel electrophoresis may improve the estimation of radiation-induced DNA repair and apoptosis" pdf

... repair, and apoptosis itself.Conclusions: The estimation of radiation-induced DNA repair by PFGE may be improved by the use of apoptosis inhibitors. The ability to simultaneously determine DNA ... by the spontaneous DNA breakage in this medium. We investigated the mechanisms of thisfragmentation with the principal aim of eliminating it in order to improve the estimation of radiation-induced ... spontaneous DNA breakage and estimate rejoining as the initial DNA released minus residual DNA re leased without the inter-ference of apoptosis. On the other hand, the intensity of apoptosis could...

Báo cáo khoa hoc:" EM-REML estimation of covariance parameters in Gaussian mixed models for longitudinal data analysis" docx

... procedures for implementing the EM algorithm tocompute REML estimates of variance covariance components in Gaussian mixed models for longitudinal data analysis. The class of models considered includes ... Vleck L.D., Estimation of the parameters involved in a ﬁrst-order autoregressive process for contemporary groups, J. DairySci. 76 (1993) 3033–3040. EM-REML for longitudinal data 131As in [3], ... D.A., Recursive estimation using mixed linear models with autoregres-sive random eﬀects, in: Variance Components and Animal Breeding, in: Proceedings of a Conference in Honor of C.R. Henderson,...

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