... nearly all isolates of
Staphylococcus aureus and some isolates of coagulase-negative staphylococci are
susceptible to these drugs. Methicillin- (actually -lactam-) resistant staphylo-
cocci have altered ... limited. The
drug is 60 % plasma protein bound and has a V
d
of about 0.24 L/kg; 60 –70% is ex-
creted in urine unchanged. The half-life is 1.5–2 hr, increasing to 6 hr in ren...
... Alfa-2a and 2b are 100% bioavailable
after IM or SC administration, with an absorption half-life of about 6 hr. IM or SC
INTERFERON ALFA:
ALFA-2A Pegasys, Roferon-A
ALFA-2B Intron A, PEG-Intron
ALFA-N3 ... to in- Cl is 60 –77 L/hr/m
2
.
active aglycones and demethyl-
ated glucuronide and sulfate con-
jugates.
144
EXCRETION
Biliary 20–30% of a 40 60 % of a Primary route Primary route...
... metabolized via CYP3A4 to the 1-hydroxy- and
4-hydroxy-metabolites; the 1-hydroxy-metabolite is at least as active as midazo-
lam. Midazolam’s half-life is 1.8 6. 4 hr.
Adverse Reactions. Respiratory ... the first of a class of selective serotonin-5-HT
1A
re-
ceptor partial agonists. It also has some effect on dopamine-D
2
autoreceptors and,
like antidepressants, can downregulate -adren...
... Steinberg KK et al. A meta-analysis of the effect of estrogen replacement therapy on the risk of breast cancer.
JAMA 1991; 265 :1985–90. {Erratum JAMA 1991: 266 :1 362 .}
140. Udoff L et al. Combined continuous ... constant-infusion ther-
apy. Diabetes 19 76; 25:72–4.
54. Heinemann L et al. Time-action profile of inhaled insulin. Diabet Med 1997;14 :63 –72.
55. Setter SM et al. Insuli...
... late-
developing cases of chronic active hepatitis have been reported; almost all are in women and after
> ;6 months of therapy.
1 ,66
Nonsteroidal Anti-inflammatory Drugs
The incidence of clinically ... deficiency.
4
Nalidixic Acid
HA In G -6 - PD deficiency; might have other mechanisms.
4
Th Scattered reports only; possibly associated with renal impairment in one series.
66
Nitr...
... ESRD.
34,35
As a conse-
quence, the elimination half-life for both drugs is increased 6- fold in the presence
of renal failure. This shows that predictions of the disposition of drugs in renal
failure ... EVALUATING DRUG DATA FOR THE ELDERLY
Because of age-related changes that may impact the outcome of drug therapy as
outlined in this chapter, the results of drug studies...