Handbook of clinical drug data - part 6 pdf

Handbook of clinical drug data - part 6 pdf

Handbook of clinical drug data - part 6 pdf

... Tablet enteric- Capsule containing Capsule con- Capsule con- Rectal suspen- coated pH mesalamine prodrug taining 5- taining ethyl- sion, sup- dependent cleaved by colonic ASA dia- cellulose- pository. (pH ... days– 16 yr. 166 Octreotide has been studied in the treatment of hyperinsulinemic hypoglycemia in neonates in different dosages. 166 , 167 SC for anti-VIP effects 3.5 ␮g/kg/day...
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Handbook of clinical drug data - part 2 pps

Handbook of clinical drug data - part 2 pps

... nearly all isolates of Staphylococcus aureus and some isolates of coagulase-negative staphylococci are susceptible to these drugs. Methicillin- (actually ␤-lactam-) resistant staphylo- cocci have altered ... limited. The drug is 60 % plasma protein bound and has a V d of about 0.24 L/kg; 60 –70% is ex- creted in urine unchanged. The half-life is 1.5–2 hr, increasing to 6 hr in ren...
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Handbook of clinical drug data - part 3 ppsx

Handbook of clinical drug data - part 3 ppsx

... Alfa-2a and 2b are 100% bioavailable after IM or SC administration, with an absorption half-life of about 6 hr. IM or SC INTERFERON ALFA: ALFA-2A Pegasys, Roferon-A ALFA-2B Intron A, PEG-Intron ALFA-N3 ... to in- Cl is 60 –77 L/hr/m 2 . active aglycones and demethyl- ated glucuronide and sulfate con- jugates. 144 EXCRETION Biliary 20–30% of a 40 60 % of a Primary route Primary route...
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Handbook of clinical drug data - part 4 pptx

Handbook of clinical drug data - part 4 pptx

... (continued) 366 ch04.qxd 8/13/2001 1: 46 PM Page 366 can LDL-c in some patients with high triglyceride levels. Gemfibrozil can in- crease biliary lipogenicity and possibly increase long-term risk of cholelithiasis. 258 Cholelithiasis ... ≥130 mg/dL 10-yr risk 10–20%: ≥130 mg/dL; 10-yr risk < 10%: ≥ 160 mg/dL 0–1 risk factor < 160 mg/dL ≥ 160 mg/dL ≥190 mg/dL ( 160 –189 mg/dL: LDL-...
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Handbook of clinical drug data - part 5 ppt

Handbook of clinical drug data - part 5 ppt

... metabolized via CYP3A4 to the 1-hydroxy- and 4-hydroxy-metabolites; the 1-hydroxy-metabolite is at least as active as midazo- lam. Midazolam’s half-life is 1.8 6. 4 hr. Adverse Reactions. Respiratory ... the first of a class of selective serotonin-5-HT 1A re- ceptor partial agonists. It also has some effect on dopamine-D 2 autoreceptors and, like antidepressants, can downregulate ␤-adren...
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Handbook of clinical drug data - part 7 ppt

Handbook of clinical drug data - part 7 ppt

... Steinberg KK et al. A meta-analysis of the effect of estrogen replacement therapy on the risk of breast cancer. JAMA 1991; 265 :1985–90. {Erratum JAMA 1991: 266 :1 362 .} 140. Udoff L et al. Combined continuous ... constant-infusion ther- apy. Diabetes 19 76; 25:72–4. 54. Heinemann L et al. Time-action profile of inhaled insulin. Diabet Med 1997;14 :63 –72. 55. Setter SM et al. Insuli...
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Handbook of clinical drug data - part 8 pptx

Handbook of clinical drug data - part 8 pptx

... late- developing cases of chronic active hepatitis have been reported; almost all are in women and after > ;6 months of therapy. 1 ,66 Nonsteroidal Anti-inflammatory Drugs The incidence of clinically ... deficiency. 4 Nalidixic Acid HA In G -6 - PD deficiency; might have other mechanisms. 4 Th Scattered reports only; possibly associated with renal impairment in one series. 66 Nitr...
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Handbook of clinical drug data - part 9 pps

Handbook of clinical drug data - part 9 pps

... ESRD. 34,35 As a conse- quence, the elimination half-life for both drugs is increased 6- fold in the presence of renal failure. This shows that predictions of the disposition of drugs in renal failure ... EVALUATING DRUG DATA FOR THE ELDERLY Because of age-related changes that may impact the outcome of drug therapy as outlined in this chapter, the results of drug studies...
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Handbook of clinical drug data - part 10 doc

Handbook of clinical drug data - part 10 doc

... test, 1070, 1073–10 76 nephrotoxicity, 843 and potassium replacement therapy, 747 Amphotericin B Cholesteryl Sulfate, 62 66 , 67 68 Amphotericin B Lipid Complex, 62 66 , 67 68 Ampicillin, 127, 155, ... Charcoal, Activated Activella, 68 0 Actonel, 76 Actos, 65 6 65 7, 65 7 Acyclovir, 99–101 breastfeeding, 919 dialysis, 968 interaction with lab test, 1071, 1074 nephrotoxicity, 842 p...
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