... 40–60 in 3 4 36 ,37 Cefmetazole HE 52–67 in 3 38Ceftazidime CONV 2 40–50 in 4 22, 39 , 40HE 58 in 3 SYN2 60–75 in 3 Cefepime HE 68 in 3 41, 42SYN 1 72 in 3. 5Cefprozil HE 55 in 3 43 Clavulanic ... of drug therapy, and, conversely, drug therapy can affect nutritional sta-tus.19 ,36 ,37 ■ EVALUATING DRUG DATA FOR THE ELDERLYBecause of age-related changes that may impact the outcome of drug ... alterations in drug metabolism. 30 ,31 Ani-mal experiments indicate that the activity of many drug metabolic pathways is re-duced in the presence of renal insufficiency by up to 70%. 32 ,33 The decrement...