Báo cáo y học: "Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations" pptx
Báo cáo y học: "Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations" pptx
... theFigure 5Nine plasma cytokine profiles in systemic sclerosis-association autoantibody subsets of scleroderma patients compared with controlsNine plasma cytokine profiles in systemic sclerosis-association ... whether circulating plasma cytokine profiles were associated with clinical involvement in SSc, plasmacytokines in patients with and without interstitial lung disease,pulmonary hypertension, SSc ... Levels of inter-leukin 12, a cytokine of type 1 helper T cells, are elevated in Table 3Plasma cytokine associations with clinical involvement of sclerodermaPresent Absent Unknown Cytokine Odds...
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Báo cáo sinh học: "Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassays" pptx
... correlation of cytokine levels with aging mayhave been influenced by various environmental factors and underlying diseases. Also, da ta regarding cytokine profiling in the elderly are limited ... termedinflammaging, characterized by an increase in proinflam-matory mediators present in serum [1,2]. Changes in T-cell homeostasis with aging are associated with a decline in immunity and increa ... been influenced by various envir-onmental factors and underlying dise ases. Additionally,data regarding cytokine profiling in the elderly have beenlimited to a small subset of cytokines. In...
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Báo cáo y học: "Complex cytokine effects in a complex autoimmune disease: tumor necrosis factor in systemic lupus erythematosus" potx
... inflammatory cytokine inter-leukin-6. Biochem Pharmacol 2000, 60:1185-1195.33. Cross JT, Benton HP: The roles of interleukin-6 and inter-leukin-10 in B cell hyperactivity in systemic lupus erythemato-sus. ... Maini RN, Feldmann M:Cytokines and anti -cytokine biologicals in autoimmunity:present and future. Cytokine Growth Factor Rev 2002, 13:299-313.66. Boswell JM, Yui MA, Burt DW, Kelley VE: Increased ... 13:833-842.61. Graninger WB, Steiner CW, Graninger MT, Aringer M, SmolenJS: Cytokine regulation of apoptosis and Bcl-2 expression in lymphocytes of patients with systemic lupus erythematosus.Cell...
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Báo cáo y học: "Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis" docx
... asynovitis with maximal swelling at 24 hours is induced bylocal injection of SCW antigen directly into an ankle joint.The initial response is reactivated by systemic (intravenous)challenge with ... arthritic inflammation was induced 14 days afterintra-articular injection (designated day 0) by intravenousinjection of 200 µg PG-PS. This resulted in monoarticulararthritis involving the joint ... The complement system has also been reported toparticipate in tissue injury during inflammatory and autoim-mune diseases [30], and ficolins can initiate the lectin path-way of complement activation...
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Báo cáo y học: "Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1β and TNFα expression profile Christine Lyn Le Maitre, Judith Alison Hoyland and Anthony J Freemont" ppsx
... articleCatabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1β and TNFα expression profileChristine Lyn Le Maitre, Judith Alison Hoyland and Anthony J FreemontTissue Injury ... these cytokines simultaneously in IVD degeneration or herniation, or determined which may be thepredominant cytokine associated with these disease states.Using quantitative real time PCR and ... Anakinra are already in clinical use for limiting car-tilage degradation in rheumatoid arthritis and osteoarthritis and, as such, its pharmacology and side effects are increas-ingly well understood...
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Báo cáo y học: "Antiphospholipid antibody profiles in lupus nephritis with glomerular microthrombosis: a prospective study of 124 cases" pot
... revealed by in vivo and in vitro studieshave indicated that aPL may influence the dynamic equilibriumbetween hemostasis and fibrinolysis by cross-reacting with some hemostatic and fibrinolytic proteases ... needle biopsy.The renal tissues obtained by biopsy were fixed in 10% neutralbuffered formalin, gradually dehydrated, and embedded in par-affin. Paraffin sections were stained with H&E, ... creatinine, and proteinuria, aswell as the frequency of systemic hypertension, were all signif-icantly greater in patients with GMT. Taken together, GMT maybe an important cause of renal injury...
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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
... or-ganelles and enzymes, increased lipid peroxidation, and development of insulin resistance (7). The vascu-lar and systemic complications in diabetes are associ-ated with hyperglycemia-induced ... revealed that insulin resistance is associated in humans with reduced intracellular antioxidant (11). Interestingly, antioxidants improve insulin sensitivity and help in wound healing (16,17). ... with the pathogenesis of insulin resistance and type 2 diabetes (48-51). In obesity and type 2 diabetes it has been reported that antioxidants and IKK-B inhibitors protect against insulin...
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Báo cáo Y học: Unique structural determinants in the signal peptides of ‘spontaneously’ inserting thylakoid membrane proteins pptx
... beensuggested that they may insert spontaneously into thethylakoid membrane.The initial stages of this spontaneous insertion mechan-ism involve binding of the intermediate-size protein to themembrane, ... important features withinthis class of signal peptide have not been studied in anysystematic manner and, because Sec- and Tat-type signalpeptides interact with proteinaceous binding sites, it ispossible ... spontaneously-inserting proteins have evolved with specific and unusual properties that are especially importantfor correct proteolytic cleavage following insertion. In thecases of PsbX and PsbY-A1,...
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Báo cáo y học: "The Inventory of Personality Organisation: its psychometric properties among student and clinical populations in Japan" pptx
... Identity Diffusion than of RealityTesting.The present study employed only students. They tended tobe young and may be well functioning and different froma population of patients with personality ... that it may be useful in both clinical and non -clinical settings as a measure of borderline personal-ity pathology.To assess predictive validity, we examined whether IPOscores at one point would ... negatively with the five sub-categories of the IPO. Only Identity Diffusion and RealityTesting were characterised by poor Autonomy. AdultAttachment styles and Self Efficacy scores were negativelycorrelated...
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Báo cáo y học: "Endothelial cell phenotypes in the rheumatoid synovium: activated, angiogenic, apoptotic and leaky" pps
... RAendothelial cells and in a variety of other cell types [114].Kinin levels are raised in RA and have been implicated in the pathogenesis of RA by causing release of cytokine and noncytokine mediators ... found, yet there is less expression. In addition, antigenic TNF-α mainly localises to macrophages in the RA lining layer and in the sublining, with someendothelial and lymphocyte staining [76,100–102]. ... K: Essential involvement ofinterleukin-8 in neutrophil recruitment in rabbits with acuteexperimental arthritis induced by lipopolysaccharide and interleukin-1. Lymphokine Cytokine Res 1994,...
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