... subtypes, and to oligodendrocytes, microglia and astrocytes in the brain, to endothelial cells, and certain T-cell subpopulations, including lymphocytes(CD4+ and CD8+T cells), cardiac myocytes, ... reduced IjBa phosphorylation[56],thus indicating that the phosphatidylinositol 3-kinase- protein kinase B ⁄ serine-threonine kinase pathway mayplay a major role in TNFR2-mediated activation ofNF-jB. ... ligand binding [31]. The intracel-lular part of TNFR1 contains a protein protein inter-action region called the death domain [32]. Afterligand binding to the TNFR1, silencer of deathdomain...