... 1343–1354.7. Kayagaki, N., Yamaguchi, N., Nakayama, M., Kawasaki, A. ,Akiba,H.,Okuma,K.&Yagita,H.(1999)InvolvementofTNF-related apoptosis-inducing ligand in human CD4+T cell-mediated cytotoxicity. ... observations, structuralchanges of TRAIL induced by acidification reveal thatTRAIL might have a potential acid-enhanced cytotoxicity and its intrinsic property be also shared by those of TNF -a and ... and PtdSer at acidic pH values. In many cases, the binding of a protein with lipid bilayer disrupts the bilayer integrity tomake the membranes permeable [30,31]. To ascertainwhether TRAIL alters...