Báo cáo y học: "Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis" pdf
Báo cáo y học: "Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis" pdf
... matrixmetalloproteinase (MMP)-1 and MMP-13 expression.Methods The expression levels of 15-lipoxygenase-1 and -2were analyzed by reverse transcription PCR and Westernblotting in chondrocytes, and by immunohistochemistry ... 1Human articular chondrocytes express both 15-LOX-1 and 15-LOX-2Human articular chondrocytes express both 15-LOX-1 and 15-LOX-2. (a) Chondrocytes were isolated from OA knee cartilage and maintained ... lipopolysaccharide-induced TNF-α expression byenhancing mRNA decay [19]. Alternatively, 15-LOX productscould prevent IL-1β-induced MMP-1 and MMP-13 expressionby interfering with key signalling...
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Báo cáo y học: "Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13" ppsx
... catabolicactivity [2]. In addition to inducing matrix degrading enzymesdirectly, these cytokines can also act by stimulating productionof additional proinflammatory cytokines. IL-6 is among thecytokines ... analysis (datanot shown).IL-7 binding assayFor flow cytometry analysis, chondrocytes were removed fromsix-well dishes by trypsin digestion and for confocal micros-copy analysis chondrocytes ... the articular chondrocytes [1]. There is increasing evidence that cytokines,including IL-1, IL-6, and tumor necrosis factor (TNF)-α, play a role in matrix destruction by enhancing chondrocyte...
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Báo cáo Y học: Apolipoprotein E predisposes to obesity and related metabolic dysfunctions in mice pdf
... vein, and glucose levels were measured.Determination of plasma insulin and leptin levelsInsulin and leptin levels in the plasma of mice were deter-mined spectrophotometrically by ELISA (Linco/Millipore,Billerica, ... 9841–9853.46 Weisgraber KH, Innerarity TL & Mahley RW (1982)Abnormal lipoprotein receptor-binding activity of thehuman E apoprotein due to cysteine–arginine inter-change at a single site. J Biol ... correlated inversely with bodyweight gain and body fat accumulation (Figs 1 and 4). In the ApoE)/)mice, failure to clear chylomicron rem-nants due to deficiency in ApoE resulted in a steadyincrease...
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Báo cáo y học: "Human meniscus cells express hypoxia inducible factor-1α and increased SOX9 in response to low oxygen tension in cell aggregate culture" ppsx
... expression in articular chondrocytes aggregates. Prolyl 4-hydroxylase (P4H)α isoenzyme gene expression in cell aggregates of articular chondrocytes in 20% oxygen (white bars) and 5% oxygen (black ... Arnoczky SP: Gross and vascular anatomy of the meniscus and its role in meniscal healing, regeneration, and remodelling. In Knee Meniscus: Basic and Clinical Foundations Edited by: MowVC, Arnoczky ... sensitivity of meniscuscells to oxygen tension. Naturally, articular chondrocytes exist in a completely avascular microenvironment, and an oxygenFigure 3Collagen types I and II, and SOX9 gene expression...
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Báo cáo y học: "Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues" pptx
... leucine-rich proteoglycans (SLRPs) – including big-lycan, decorin, fibromodulin, lumican and keratocan – playimportant linking, shape determining and matrix organizingroles [14-16]. These roles ... resistant to proteolysisthan the other SLRPs or that fibromodulin degradation prod-ucts retaining the carboxyl-terminus may not be stably retained in the tissue and are lost into the synovial fluid. ... knee and hip articular articular cartilage, con-sistent with ADAMTS (a disintegrin and metalloproteasedomain with thrombospondin type I motifs) cleavage. Decorin,biglycan and fibromodulin can...
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báo cáo hóa học:" Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function" ppt
... post-culture by flow cytometry analysis (B). Expression of FoxP3 and CD25 were determined in freshly isolated CD4+ T cells (day 0) and after a 3-day stimu-lation with anti-CD3/CD28 Abs (C). Freshly isolated ... T cells induces expression of CD25 and Foxp3 associated with effector and memory phenotype differentiationPBMC were stimulated with bryostatin-1 (5 nM) and ion-omycin (1 M) (B/I) in the presence ... activation mimic intracellularsignals that result in T cell activation by increasing proteinkinase C activity and intracellular calcium, respectively[18-20]. Cells were washed three times and cultured...
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Báo cáo y học: "Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action" pps
... MMPs increases in OA by either an increase in theirown synthesis, an increased activation by their proen-zymes, or decreased activity of their inhibitors [29]. Pro-inflammatory cytokines, including ... involved in cartilage catabolism by inhibiting the synthesis of colla-gen and PG, enhancing MMP activity, reducing the synthe-sis of an IL-1 receptor antagonist by chondrocytes, and increasing susceptibility ... studies investi-gating the effects of HA and hylans on cartilage in well-controlled clinical studies may help determine whetherintra -articular HA and hylans aid in chondroprotection and slowing...
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Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"
... complications including coronary heart dis-ease, retinopathy, nephropathy, and neuropathy [3, 4]. In addition, chronic hyperglycemia leads to progres-sive impairment of insulin secretion and to insulin ... they are not hydrolysed by β-glucosidases in the intestine and can be adminis-tered orally [27]. Therefore, the aim of the present study was to evaluate the inhibitory effect of some thioglycosides ... [16]. It in- hibits the activity of SGLT in the kidney leading to glycosuria [17]. Its clinical application; however, is restricted due to hydrolysis by β-glucosidases in the intestine [12]....
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Báo cáo y học: "Plasmatic B-Type Natriuretic Peptide and C-Reactive Protein in Hyperacute Stroke as Markers of Ct-Evidence of Brain Edema." pptx
... Kistorp C, Raymond I, Pedersen F, Gustafsson F, Faber J, Hildebrandt P. N-terminal pro-brain natriuretic peptide, C-reactive protein, and urinary albumin levels as predictors of mortality and cardiovascular ... patients being independent. None of the patients included in the study had overt evidence of infection on admission on the basis of standard blood and urine tests, X-film of the chest and temperature ... baseline and after 48 hours respectively. Given that brain edema may be a life-threatening condition, anti-edema measures could be anticipated in hyperacute stroke in patients with high baseline...
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Báo cáo y học: "Coincidence of paroxysmal supraventricular tachycardia and panic disorder: two case reports" pdf
... precipitating and maintaining PD via interoceptive processes or, alternatively, with PD increasing the risk for PSVT by elevating stress levels. As both PSVT and PD require different treatments, potentially ... PSVT and atachycardic state within a panic attack. During an inva-sive electrophysiological study in July 2000, a rapid typi-cal AV nodal re-entrant tachycardia was diagnosed, withinduced cycle ... age of 18, occurring two to three times per week last-ing for about 10 to 30 min and presenting with somaticsymptoms including palpitations and tachycardia not ter-minable by vagal manoeuvres,...
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